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Start Over Author "Whittaker, P." Journal nature communications
25 results on '"Whittaker, P."'

3. Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Author

Patel, Harsita, Carter, Michael J., Jackson, Heather, Powell, Oliver, Fish, Matthew, Terranova-Barberio, Manuela, Spada, Filomena, Petrov, Nedyalko, Wellman, Paul, Darnell, Sarah, Mustafa, Sobia, Todd, Katrina, Bishop, Cynthia, Cohen, Jonathan M., Kenny, Julia, van den Berg, Sarah, Sun, Thomas, Davis, Francesca, Jennings, Aislinn, Timms, Emma, Thomas, Jessica, Nyirendra, Maggie, Nichols, Samuel, Estamiana Elorieta, Leire, D’Souza, Giselle, Wright, Victoria, De, Tisham, Habgood-Coote, Dominic, Ramnarayan, Padmanabhan, Tissières, Pierre, Whittaker, Elizabeth, Herberg, Jethro, Cunnington, Aubrey, Kaforou, Myrsini, Ellis, Richard, Malim, Michael H., Tibby, Shane M., Shankar-Hari, Manu, and Levin, Michael

Published
2024
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4. The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

Author

Rehman, Saima, Antonovic, Anna Katarina, McIntire, Ian E., Zheng, Huaixin, Cleaver, Leanne, Baczynska, Maria, Adams, Carlton O., Portlock, Theo, Richardson, Katherine, Shaw, Rosie, Oregioni, Alain, Mastroianni, Giulia, Whittaker, Sara B-M., Kelly, Geoff, Lorenz, Christian D., Fornili, Arianna, Cianciotto, Nicholas P., and Garnett, James A.

Published
2024
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5. Author Correction: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context

Author

Sheppard, Richard J., Watson, Oliver J., Pieciak, Rachel, Lungu, James, Kwenda, Geoffrey, Moyo, Crispin, Chanda, Stephen Longa, Barnsley, Gregory, Brazeau, Nicholas F., Gerard-Ursin, Ines C. G., Olivera Mesa, Daniela, Whittaker, Charles, Gregson, Simon, Okell, Lucy C., Ghani, Azra C., MacLeod, William B., Del Fava, Emanuele, Melegaro, Alessia, Hines, Jonas Z., Mulenga, Lloyd B., Walker, Patrick G. T., Mwananyanda, Lawrence, and Gill, Christopher J.

Published
2024
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7. Global disparities in SARS-CoV-2 genomic surveillance

Author

Brito, Anderson F, Semenova, Elizaveta, Dudas, Gytis, Hassler, Gabriel W, Kalinich, Chaney C, Kraemer, Moritz UG, Ho, Joses, Tegally, Houriiyah, Githinji, George, Agoti, Charles N, Matkin, Lucy E, Whittaker, Charles, Howden, Benjamin P, Sintchenko, Vitali, Zuckerman, Neta S, Mor, Orna, Blankenship, Heather M, de Oliveira, Tulio, Lin, Raymond TP, Siqueira, Marilda Mendonça, Resende, Paola Cristina, Vasconcelos, Ana Tereza R, Spilki, Fernando R, Aguiar, Renato Santana, Alexiev, Ivailo, Ivanov, Ivan N, Philipova, Ivva, Carrington, Christine VF, Sahadeo, Nikita SD, Branda, Ben, Gurry, Céline, Maurer-Stroh, Sebastian, Naidoo, Dhamari, von Eije, Karin J, Perkins, Mark D, van Kerkhove, Maria, Hill, Sarah C, Sabino, Ester C, Pybus, Oliver G, Dye, Christopher, Bhatt, Samir, Flaxman, Seth, Suchard, Marc A, Grubaugh, Nathan D, Baele, Guy, and Faria, Nuno R

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Health Sciences, Prevention, Human Genome, Biodefense, Vaccine Related, Immunization, Emerging Infectious Diseases, Genetics, Infection, Good Health and Well Being, Humans, SARS-CoV-2, Genome, Viral, COVID-19, Pandemics, Genomics, Bulgarian SARS-CoV-2 sequencing group, Communicable Diseases Genomics Network, COVID-19 Impact Project, Danish Covid-19 Genome Consortium, Fiocruz COVID-19 Genomic Surveillance Network, GISAID core curation team, Network for Genomic Surveillance in South Africa, Swiss SARS-CoV-2 Sequencing Consortium
Abstract

Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, and guide public health responses. To investigate the global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID to estimate the impact of sequencing intensity and turnaround times on variant detection in 189 countries. In the first two years of the pandemic, 78% of high-income countries sequenced >0.5% of their COVID-19 cases, while 42% of low- and middle-income countries reached that mark. Around 25% of the genomes from high income countries were submitted within 21 days, a pattern observed in 5% of the genomes from low- and middle-income countries. We found that sequencing around 0.5% of the cases, with a turnaround time

Published
2022

8. Ion complexation waves emerge at the curved interfaces of layered minerals

Author

Whittaker, Michael L, Ren, David, Ophus, Colin, Zhang, Yugang, Waller, Laura, Gilbert, Benjamin, and Banfield, Jillian F

Subjects
Chemical Sciences, Physical Sciences, Condensed Matter Physics, Electrolytes, Minerals, Water, CSD-08-GEO-A, CSD-46-All CSGB, CSD-45-Featured
Abstract

Visualizing hydrated interfaces is of widespread interest across the physical sciences and is a particularly acute need for layered minerals, whose properties are governed by the structure of the electric double layer (EDL) where mineral and solution meet. Here, we show that cryo electron microscopy and tomography enable direct imaging of the EDL at montmorillonite interfaces in monovalent electrolytes with ångstrom resolution over micron length scales. A learning-based multiple-scattering reconstruction method for cryo electron tomography reveals ions bound asymmetrically on opposite sides of curved, exfoliated layers. We observe conserved ion-density asymmetry across stacks of interacting layers in cryo electron microscopy that is associated with configurations of inner- and outer-sphere ion-water-mineral complexes that we term complexation waves. Coherent X-ray scattering confirms that complexation waves propagate at room-temperature via a competition between ion dehydration and charge interactions that are coupled across opposing sides of a layer, driving dynamic transitions between stacked and aggregated states via layer exfoliation.

Published
2022

9. Leukemia-intrinsic determinants of CAR-T response revealed by iterative in vivo genome-wide CRISPR screening

Author

Ramos, Azucena, Koch, Catherine E., Liu-Lupo, Yunpeng, Hellinger, Riley D., Kyung, Taeyoon, Abbott, Keene L., Fröse, Julia, Goulet, Daniel, Gordon, Khloe S., Eidell, Keith P., Leclerc, Paul, Whittaker, Charles A., Larson, Rebecca C., Muscato, Audrey J., Yates, Kathleen B., Dubrot, Juan, Doench, John G., Regev, Aviv, Vander Heiden, Matthew G., Maus, Marcela V., Manguso, Robert T., Birnbaum, Michael E., and Hemann, Michael T.

Published
2023
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11. Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

Author

Rasooly, Danielle, Peloso, Gina M., Pereira, Alexandre C., Dashti, Hesam, Giambartolomei, Claudia, Wheeler, Eleanor, Aung, Nay, Ferolito, Brian R., Pietzner, Maik, Farber-Eger, Eric H., Wells, Quinn Stanton, Kosik, Nicole M., Gaziano, Liam, Posner, Daniel C., Bento, A. Patrícia, Hui, Qin, Liu, Chang, Aragam, Krishna, Wang, Zeyuan, Charest, Brian, Huffman, Jennifer E., Wilson, Peter W. F., Phillips, Lawrence S., Whittaker, John, Munroe, Patricia B., Petersen, Steffen E., Cho, Kelly, Leach, Andrew R., Magariños, María Paula, Gaziano, John Michael, Langenberg, Claudia, Sun, Yan V., Joseph, Jacob, and Casas, Juan P.

Published
2023
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12. Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context

Author

Sheppard, Richard J., Watson, Oliver J., Pieciak, Rachel, Lungu, James, Kwenda, Geoffrey, Moyo, Crispin, Chanda, Stephen Longa, Barnsley, Gregory, Brazeau, Nicholas F., Gerard-Ursin, Ines C. G., Olivera Mesa, Daniela, Whittaker, Charles, Gregson, Simon, Okell, Lucy C., Ghani, Azra C., MacLeod, William B., Del Fava, Emanuele, Melegaro, Alessia, Hines, Jonas Z., Mulenga, Lloyd B., Walker, Patrick G. T., Mwananyanda, Lawrence, and Gill, Christopher J.

Published
2023
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14. 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial

Author

Othonos, Nantia, Pofi, Riccardo, Arvaniti, Anastasia, White, Sarah, Bonaventura, Ilaria, Nikolaou, Nikolaos, Moolla, Ahmad, Marjot, Thomas, Stimson, Roland H., van Beek, André P., van Faassen, Martijn, Isidori, Andrea M., Bateman, Elizabeth, Sadler, Ross, Karpe, Fredrik, Stewart, Paul M., Webster, Craig, Duffy, Joanne, Eastell, Richard, Gossiel, Fatma, Cornfield, Thomas, Hodson, Leanne, Jane Escott, K., Whittaker, Andrew, Kirik, Ufuk, Coleman, Ruth L., Scott, Charles A. B., Milton, Joanne E., Agbaje, Olorunsola, Holman, Rury R., and Tomlinson, Jeremy W.

Published
2023
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16. Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Author

De Logu, Francesco, Nassini, Romina, Hegron, Alan, Landini, Lorenzo, Jensen, Dane D., Latorre, Rocco, Ding, Julia, Marini, Matilde, Souza Monteiro de Araujo, Daniel, Ramírez-Garcia, Paulina, Whittaker, Michael, Retamal, Jeffri, Titiz, Mustafa, Innocenti, Alessandro, Davis, Thomas P., Veldhuis, Nicholas, Schmidt, Brian L., Bunnett, Nigel W., and Geppetti, Pierangelo

Published
2022
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19. Reduction in mobility and COVID-19 transmission

Author

Nouvellet, Pierre, Bhatia, Sangeeta, Cori, Anne, Ainslie, Kylie E. C., Baguelin, Marc, Bhatt, Samir, Boonyasiri, Adhiratha, Brazeau, Nicholas F., Cattarino, Lorenzo, Cooper, Laura V., Coupland, Helen, Cucunuba, Zulma M., Cuomo-Dannenburg, Gina, Dighe, Amy, Djaafara, Bimandra A., Dorigatti, Ilaria, Eales, Oliver D., van Elsland, Sabine L., Nascimento, Fabricia F., FitzJohn, Richard G., Gaythorpe, Katy A. M., Geidelberg, Lily, Green, William D., Hamlet, Arran, Hauck, Katharina, Hinsley, Wes, Imai, Natsuko, Jeffrey, Benjamin, Knock, Edward, Laydon, Daniel J., Lees, John A., Mangal, Tara, Mellan, Thomas A., Nedjati-Gilani, Gemma, Parag, Kris V., Pons-Salort, Margarita, Ragonnet-Cronin, Manon, Riley, Steven, Unwin, H. Juliette T., Verity, Robert, Vollmer, Michaela A. C., Volz, Erik, Walker, Patrick G. T., Walters, Caroline E., Wang, Haowei, Watson, Oliver J., Whittaker, Charles, Whittles, Lilith K., Xi, Xiaoyue, Ferguson, Neil M., and Donnelly, Christl A.

Published
2021
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21. Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity

Author

Ryan, Kathryn A., Bewley, Kevin R., Fotheringham, Susan A., Slack, Gillian S., Brown, Phillip, Hall, Yper, Wand, Nadina I., Marriott, Anthony C., Cavell, Breeze E., Tree, Julia A., Allen, Lauren, Aram, Marilyn J., Bean, Thomas J., Brunt, Emily, Buttigieg, Karen R., Carter, Daniel P., Cobb, Rebecca, Coombes, Naomi S., Findlay-Wilson, Steve J., Godwin, Kerry J., Gooch, Karen E., Gouriet, Jade, Halkerston, Rachel, Harris, Debbie J., Hender, Thomas H., Humphries, Holly E., Hunter, Laura, Ho, Catherine M. K., Kennard, Chelsea L., Leung, Stephanie, Longet, Stephanie, Ngabo, Didier, Osman, Karen L., Paterson, Jemma, Penn, Elizabeth J., Pullan, Steven T., Rayner, Emma, Skinner, Oliver, Steeds, Kimberley, Taylor, Irene, Tipton, Tom, Thomas, Stephen, Turner, Carrie, Watson, Robert J., Wiblin, Nathan R., Charlton, Sue, Hallis, Bassam, Hiscox, Julian A., Funnell, Simon, Dennis, Mike J., Whittaker, Catherine J., Catton, Michael G., Druce, Julian, Salguero, Francisco J., and Carroll, Miles W.

Published
2021
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22. Scaling advantage over path-integral Monte Carlo in quantum simulation of geometrically frustrated magnets

Author

King, Andrew D., Raymond, Jack, Lanting, Trevor, Isakov, Sergei V., Mohseni, Masoud, Poulin-Lamarre, Gabriel, Ejtemaee, Sara, Bernoudy, William, Ozfidan, Isil, Smirnov, Anatoly Yu., Reis, Mauricio, Altomare, Fabio, Babcock, Michael, Baron, Catia, Berkley, Andrew J., Boothby, Kelly, Bunyk, Paul I., Christiani, Holly, Enderud, Colin, Evert, Bram, Harris, Richard, Hoskinson, Emile, Huang, Shuiyuan, Jooya, Kais, Khodabandelou, Ali, Ladizinsky, Nicolas, Li, Ryan, Lott, P. Aaron, MacDonald, Allison J. R., Marsden, Danica, Marsden, Gaelen, Medina, Teresa, Molavi, Reza, Neufeld, Richard, Norouzpour, Mana, Oh, Travis, Pavlov, Igor, Perminov, Ilya, Prescott, Thomas, Rich, Chris, Sato, Yuki, Sheldan, Benjamin, Sterling, George, Swenson, Loren J., Tsai, Nicholas, Volkmann, Mark H., Whittaker, Jed D., Wilkinson, Warren, Yao, Jason, Neven, Hartmut, Hilton, Jeremy P., Ladizinsky, Eric, Johnson, Mark W., and Amin, Mohammad H.

Published
2021
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23. State-level tracking of COVID-19 in the United States

Author

Unwin, H. Juliette T., Mishra, Swapnil, Bradley, Valerie C., Gandy, Axel, Mellan, Thomas A., Coupland, Helen, Ish-Horowicz, Jonathan, Vollmer, Michaela A. C., Whittaker, Charles, Filippi, Sarah L., Xi, Xiaoyue, Monod, Mélodie, Ratmann, Oliver, Hutchinson, Michael, Valka, Fabian, Zhu, Harrison, Hawryluk, Iwona, Milton, Philip, Ainslie, Kylie E. C., Baguelin, Marc, Boonyasiri, Adhiratha, Brazeau, Nick F., Cattarino, Lorenzo, Cucunuba, Zulma, Cuomo-Dannenburg, Gina, Dorigatti, Ilaria, Eales, Oliver D., Eaton, Jeffrey W., van Elsland, Sabine L., FitzJohn, Richard G., Gaythorpe, Katy A. M., Green, William, Hinsley, Wes, Jeffrey, Benjamin, Knock, Edward, Laydon, Daniel J., Lees, John, Nedjati-Gilani, Gemma, Nouvellet, Pierre, Okell, Lucy, Parag, Kris V., Siveroni, Igor, Thompson, Hayley A., Walker, Patrick, Walters, Caroline E., Watson, Oliver J., Whittles, Lilith K., Ghani, Azra C., Ferguson, Neil M., Riley, Steven, Donnelly, Christl A., Bhatt, Samir, and Flaxman, Seth

Published
2020
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25. Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Author

Iglesias, AI, Mishra, A, Vitart, V, Bykhovskaya, Y, Hoehn, R, Springelkamp, H, Cuellar-Partida, G, Gharahkhani, P, Bailey, JNC, Willoughby, CE, Li, X, Yazar, S, Nag, A, Khawaja, AP, Polasek, O, Siscovick, D, Mitchell, P, Tham, YC, Haines, JL, Kearns, LS, Hayward, C, Shi, Y, van Leeuwen, EM, Taylor, KD, Bonnemaijer, P, Rotter, JI, Martin, NG, Zeller, T, Mills, RA, Souzeau, E, Staffieri, SE, Jonas, JB, Schmidtmann, I, Boutin, T, Kang, JH, Lucas, SEM, Wong, TY, Beutel, ME, Wilson, JF, Uitterlinden, AG, Vithana, EN, Foster, PJ, Hysi, PG, Hewitt, AW, Khor, CC, Pasquale, LR, Montgomery, GW, Klaver, CCW, Aung, T, Pfeiffer, N, Mackey, DA, Hammond, CJ, Cheng, C-Y, Craig, JE, Rabinowitz, YS, Wiggs, JL, Burdon, KP, van Duijn, CM, MacGregor, S, Wang, JJ, Rochtchina, E, Attia, J, Scott, R, Holliday, EG, Baird, PN, Xie, J, Inouye, M, Viswanathan, A, Sim, X, Allingham, RR, Brilliant, MH, Budenz, DL, Christen, WG, Fingert, J, Friedman, DS, Gaasterland, D, Gaasterland, T, Hauser, MA, Kraft, P, Lee, RK, Lichter, PR, Liu, Y, Loomis, SJ, Moroi, SE, Pericak-Vance, MA, Realini, A, Richards, JE, Schuman, JS, Scott, WK, Singh, K, Sit, AJ, Vollrath, D, Weinreb, RN, Wollstein, G, Zack, DJ, Zhang, K, Donnelly, P, Barroso, I, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Deloukas, P, Duncanson, A, Jankowski, J, Markus, HS, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Wood, NW, Spencer, CCA, Band, G, Bellenguez, C, Freeman, C, Hellenthal, G, Giannoulatou, E, Pirinen, M, Pearson, R, Strange, A, Su, Z, Vukcevic, D, Langford, C, Hunt, SE, Edkins, S, Gwilliam, R, Blackburn, H, Bumpstead, SJ, Dronov, S, Gillman, M, Gray, E, Hammond, N, Jayakumar, A, McCann, OT, Liddle, J, Potter, SC, Ravindrarajah, R, Ricketts, M, Waller, M, Weston, P, Widaa, S, Whittaker, P, Grp, BMES-G, Consortium, N, and Control, WTC

Subjects
Lumican, genetic structures, Fibrillin-1, General Physics and Astronomy, Gene Expression, Q1, Corneal Diseases, Marfan Syndrome, Cornea, ADAMTS Proteins, Myopia, Link (knot theory), lcsh:Science, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Corneal Dystrophies, Hereditary, Multidisciplinary, Eye Diseases, Hereditary, symbols, NEIGHBORHOOD consortium, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Proteoglycans, Decorin, Glaucoma, Open-Angle, Science, Quantitative Trait Loci, Computational biology, Biology, Keratoconus, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, White People, Article, symbols.namesake, Transforming Growth Factor beta2, Quantitative Trait, Heritable, Asian People, Genome-Wide Association Analysis, Humans, Author Correction, Eye Disease and Disorders of Vision, Loeys-Dietz Syndrome, Genome, Human, Wellcome Trust Case Control Consortium 2, Blue Mountains Eye Study - GWAS group, General Chemistry, Mendelian Randomization Analysis, R1, eye diseases, Mendelian inheritance, Ehlers-Danlos Syndrome, lcsh:Q, sense organs, Genome-Wide Association Study
Abstract

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r = −0.62, P = 5.30 × 10−5) but not between CCT and primary open-angle glaucoma (r = −0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation., Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.

Published
2019
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