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Start Over Author "Wise, Petra" Journal nature communications
2 results on '"Wise, Petra"'

1. Publisher Correction: Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.

Author

Vannini, Ivan, Wise, Petra M, Challagundla, Kishore B, Plousiou, Meropi, Raffini, Mirco, Bandini, Erika, Fanini, Francesca, Paliaga, Giorgia, Crawford, Melissa, Ferracin, Manuela, Ivan, Cristina, Fabris, Linda, Davuluri, Ramana V, Guo, Zhiyi, Cortez, Maria Angelica, Zhang, Xinna, Chen, Lu, Zhang, Shuxing, Fernandez-Cymering, Cecilia, Han, Leng, Carloni, Silvia, Salvi, Samanta, Ling, Hui, Murtadha, Mariam, Neviani, Paolo, Gitlitz, Barbara J, Laird-Offringa, Ite A, Nana-Sinkam, Patrick, Negrini, Massimo, Liang, Han, Amadori, Dino, Cimmino, Amelia, Calin, George A, and Fabbri, Muller

Abstract

In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been corrected in both the PDF and HTML versions of the Article.

Published
2018

2. Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.

Author

Vannini, Ivan, Wise, Petra M, Challagundla, Kishore B, Plousiou, Meropi, Raffini, Mirco, Bandini, Erika, Fanini, Francesca, Paliaga, Giorgia, Crawford, Melissa, Ferracin, Manuela, Ivan, Cristina, Fabris, Linda, Davuluri, Ramana V, Guo, Zhiyi, Cortez, Maria Angelica, Zhang, Xinna, Chen, Lu, Zhang, Shuxing, Fernandez-Cymering, Cecilia, Han, Leng, Carloni, Silvia, Salvi, Samanta, Ling, Hui, Murtadha, Mariam, Neviani, Paolo, Gitlitz, Barbara J, Laird-Offringa, Ite A, Nana-Sinkam, Patrick, Negrini, Massimo, Liang, Han, Amadori, Dino, Cimmino, Amelia, Calin, George A, and Fabbri, Muller

Subjects
Lung, Cell Line, Tumor, Animals, Humans, Mice, Mice, Nude, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Cyclins, MicroRNAs, Xenograft Model Antitumor Assays, Cell Proliferation, Down-Regulation, Gene Expression Regulation, Neoplastic, Up-Regulation, Base Sequence, Conserved Sequence, Genes, Tumor Suppressor, Female, RNA, Long Noncoding, Carcinogenesis, Cell Line, Tumor, Nude, Carcinoma, Non-Small-Cell Lung, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, RNA, Long Noncoding
Abstract

The transcribed ultraconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis. Their mechanisms of action and the factors regulating their expression in cancers are poorly understood. Here we show that high expression of uc.339 correlates with lower survival in 210 non-small cell lung cancer (NSCLC) patients. We provide evidence from cell lines and primary samples that TP53 directly regulates uc.339. We find that transcribed uc.339 is upregulated in archival NSCLC samples, functioning as a decoy RNA for miR-339-3p, -663b-3p, and -95-5p. As a result, Cyclin E2, a direct target of all these microRNAs is upregulated, promoting cancer growth and migration. Finally, we find that modulation of uc.339 affects microRNA expression. However, overexpression or downregulation of these microRNAs causes no significant variations in uc.339 levels, suggesting a type of interaction for uc.339 that we call "entrapping". Our results support a key role for uc.339 in lung cancer.

Published
2017

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