Search

Your search keyword '"Wood, Matthew"' showing total 9 results
Start Over Author "Wood, Matthew" Journal nature communications
9 results on '"Wood, Matthew"'

4. Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Author

Dar, Ghulam Hassan, Mendes, Cláudia C., Kuan, Wei-Li, Speciale, Alfina A., Conceição, Mariana, Görgens, André, Uliyakina, Inna, Lobo, Miguel J., Lim, Wooi F., EL Andaloussi, Samir, Mäger, Imre, Roberts, Thomas C., Barker, Roger A., Goberdhan, Deborah C. I., Wilson, Clive, and Wood, Matthew J. A.

Published
2021
Full Text
View/download PDF

5. Numerical chromosomal instability mediates susceptibility to radiation treatment

Author

Bakhoum, Samuel F, Kabeche, Lilian, Wood, Matthew D, Laucius, Christopher D, Qu, Dian, Laughney, Ashley M, Reynolds, Gloria E, Louie, Raymond J, Phillips, Joanna, Chan, Denise A, Zaki, Bassem I, Murnane, John P, Petritsch, Claudia, and Compton, Duane A

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Human Genome, Genetics, Cancer, Aneuploidy, Animals, Brain Neoplasms, Cell Cycle, Cell Death, Cell Line, Tumor, Cell Survival, Chromosomal Instability, Chromosome Breakage, Chromosome Segregation, Glioblastoma, HCT116 Cells, Humans, Male, Mice, Mice, Nude, Micronucleus Tests, Mitosis, Neoplasm Transplantation, Neoplasms, Radiation, Ionizing
Abstract

The exquisite sensitivity of mitotic cancer cells to ionizing radiation (IR) underlies an important rationale for the widely used fractionated radiation therapy. However, the mechanism for this cell cycle-dependent vulnerability is unknown. Here we show that treatment with IR leads to mitotic chromosome segregation errors in vivo and long-lasting aneuploidy in tumour-derived cell lines. These mitotic errors generate an abundance of micronuclei that predispose chromosomes to subsequent catastrophic pulverization thereby independently amplifying radiation-induced genome damage. Experimentally suppressing whole-chromosome missegregation reduces downstream chromosomal defects and significantly increases the viability of irradiated mitotic cells. Further, orthotopically transplanted human glioblastoma tumours in which chromosome missegregation rates have been reduced are rendered markedly more resistant to IR, exhibiting diminished markers of cell death in response to treatment. This work identifies a novel mitotic pathway for radiation-induced genome damage, which occurs outside of the primary nucleus and augments chromosomal breaks. This relationship between radiation treatment and whole-chromosome missegregation can be exploited to modulate therapeutic response in a clinically relevant manner.

Published
2015

8. The viral protein corona directs viral pathogenesis and amyloid aggregation

Author

Ezzat, Kariem, Pernemalm, Maria, Pålsson, Sandra, Roberts, Thomas C., Järver, Peter, Dondalska, Aleksandra, Bestas, Burcu, Sobkowiak, Michal J., Levänen, Bettina, Sköld, Magnus, Thompson, Elizabeth A., Saher, Osama, Kari, Otto K., Lajunen, Tatu, Sverremark Ekström, Eva, Nilsson, Caroline, Ishchenko, Yevheniia, Malm, Tarja, Wood, Matthew J. A., Power, Ultan F., Masich, Sergej, Lindén, Anders, Sandberg, Johan K., Lehtiö, Janne, Spetz, Anna-Lena, and EL Andaloussi, Samir

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results