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Your search keyword '"ZENG, YU"' showing total 14 results
Start Over Author "ZENG, YU" Journal nature communications
14 results on '"ZENG, YU"'

7. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement

Author

Liu, Jiaye, Wang, Yang, Mu, Chunyang, Li, Meng, Li, Kewei, Li, Shan, Wu, Wenshuang, Du, Lingyao, Zhang, Xiaoyun, Li, Chuan, Peng, Wei, Shen, Junyi, Liu, Yang, Yang, Dujiang, Zhang, Kaixiang, Ning, Qingyang, Fu, Xiaoying, Zeng, Yu, Ni, Yinyun, Zhou, Zongguang, Liu, Yi, Hu, Yiguo, Zheng, Xiaofeng, Wen, Tianfu, Li, Zhihui, and Liu, Yong

Published
2022
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8. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

Author

Xia Wang, Jin Wang, Yu-Man Tsui, Chaoran Shi, Ying Wang, Xin Zhang, Qian Yan, Miao Chen, Chen Jiang, Yun-Fei Yuan, Chun-Ming Wong, Ming Liu, Zeng-yu Feng, Honglin Chen, Irene Oi Lin Ng, Lingxi Jiang, and Xin-Yuan Guan

Subjects
Science
Abstract

RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.

Published
2021
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13. Electrical and magnetic anisotropies in van der Waals multiferroic CuCrP2S6.

Author

Wang, Xiaolei, Shang, Zixuan, Zhang, Chen, Kang, Jiaqian, Liu, Tao, Wang, Xueyun, Chen, Siliang, Liu, Haoliang, Tang, Wei, Zeng, Yu-Jia, Guo, Jianfeng, Cheng, Zhihai, Liu, Lei, Pan, Dong, Tong, Shucheng, Wu, Bo, Xie, Yiyang, Wang, Guangcheng, Deng, Jinxiang, and Zhai, Tianrui

Subjects
MAGNONS, MAGNETIC anisotropy, MAGNETIC declination, MULTIFERROIC materials, MAGNETIC properties, BIONICS, MAGNETIC fields, ANISOTROPY
Abstract

Multiferroic materials have great potential in non-volatile devices for low-power and ultra-high density information storage, owing to their unique characteristic of coexisting ferroelectric and ferromagnetic orders. The effective manipulation of their intrinsic anisotropy makes it promising to control multiple degrees of the storage "medium". Here, we have discovered intriguing in-plane electrical and magnetic anisotropies in van der Waals (vdW) multiferroic CuCrP2S6. The uniaxial anisotropies of current rectifications, magnetic properties and magnon modes are demonstrated and manipulated by electric direction/polarity, temperature variation and magnetic field. More important, we have discovered the spin-flop transition corresponding to specific resonance modes, and determined the anisotropy parameters by consistent model fittings and theoretical calculations. Our work provides in-depth investigation and quantitative analysis of electrical and magnetic anisotropies with the same easy axis in vdW multiferroics, which will stimulate potential device applications of artificial bionic synapses, multi-terminal spintronic chips and magnetoelectric devices. Manipulating electrical and magnetic anisotropies will stimulate multi-terminal device applications. Here, the authors discover axis dependence of current rectifications, magnetic properties and magnon modes in van der Waals multiferroic CuCrP2S6. [ABSTRACT FROM AUTHOR]

Published
2023
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14. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2

Author

Ying Wang, Yunfei Yuan, Chaoran Shi, Miao Chen, Honglin Chen, Jin Wang, Irene Oi-Lin Ng, Xin Zhang, Qian Yan, Lingxi Jiang, Ming Liu, Yu-Man Tsui, Chen Jiang, Xia Wang, Chun-Ming Wong, Zeng-Yu Feng, and Xin Yuan Guan

Subjects
Male, 0301 basic medicine, RNA Stability, Cellular differentiation, General Physics and Astronomy, Metastasis, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Cell Movement, Cancer, Regulation of gene expression, Multidisciplinary, Liver Neoplasms, RNA-Binding Proteins, Cell Differentiation, Middle Aged, Up-Regulation, Gene Expression Regulation, Neoplastic, Liver, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Female, Liver cancer, Signal Transduction, STAT3 Transcription Factor, Carcinoma, Hepatocellular, Science, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Transforming Growth Factor beta2, 03 medical and health sciences, Cancer stem cell, Cell Line, Tumor, medicine, Animals, Humans, Progenitor cell, Embryonic Stem Cells, PI3K/AKT/mTOR pathway, Progenitor, Heterogeneous-Nuclear Ribonucleoprotein Group C, General Chemistry, medicine.disease, Embryonic stem cell, digestive system diseases, 030104 developmental biology, Cancer research
Abstract

Growing evidences suggest that cancer stem cells exhibit many molecular characteristics and phenotypes similar to their ancestral progenitor cells. In the present study, human embryonic stem cells are induced to differentiate into hepatocytes along hepatic lineages to mimic liver development in vitro. A liver progenitor specific gene, RALY RNA binding protein like (RALYL), is identified. RALYL expression is associated with poor prognosis, poor differentiation, and metastasis in clinical HCC patients. Functional studies reveal that RALYL could promote HCC tumorigenicity, self-renewal, chemoresistance, and metastasis. Moreover, molecular mechanism studies show that RALYL could upregulate TGF-β2 mRNA stability by decreasing N6-methyladenosine (m6A) modification. TGF-β signaling and the subsequent PI3K/AKT and STAT3 pathways, upregulated by RALYL, contribute to the enhancement of HCC stemness. Collectively, RALYL is a liver progenitor specific gene and regulates HCC stemness by sustaining TGF-β2 mRNA stability. These findings may inspire precise therapeutic strategies for HCC., RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.

Published
2021

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