Search

Your search keyword '"Zhanpeng, Ou"' showing total 1 results
Start Over Author "Zhanpeng, Ou" Journal nature communications
1 results on '"Zhanpeng, Ou"'

1. Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Author

Xinyuan Lei, Hsinyu Lin, Jieqi Wang, Zhanpeng Ou, Yi Ruan, Ananthan Sadagopan, Weixiong Chen, Shule Xie, Baisheng Chen, Qunxing Li, Jue Wang, Huayue Lin, Xiaofeng Zhu, Xiaoqing Yuan, Tian Tian, Xiaobin Lv, Sha Fu, Xiaorui Zhu, Jian Zhou, Guokai Pan, Xin Xia, Bakhos A. Tannous, Soldano Ferrone, Song Fan, and Jinsong Li

Subjects
Science
Abstract

Cancer cells downregulate surface expression of major histocompatibility complex I (MHC-I) for immune evasion. Here, the authors show that rapid mitochondrial fission activates the ER-stress response leading to reduced MHC-I complex formation and cell surface expression in solid cancer cells; moreover inhibition of mitochondrial fission increases the immune-mediated anticancer response in murine models.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results