Search

Your search keyword '"Zhi Ren Liu"' showing total 3 results
Start Over Author "Zhi Ren Liu" Journal nature communications
3 results on '"Zhi Ren Liu"'

1. Early detection and staging of chronic liver diseases with a protein MRI contrast agent

Author

Mani Salarian, Ravi Chakra Turaga, Shenghui Xue, Maysam Nezafati, Khan Hekmatyar, Jingjuan Qiao, Yinwei Zhang, Shanshan Tan, Oluwatosin Y. Ibhagui, Yan Hai, Jibiao Li, Rao Mukkavilli, Malvika Sharma, Pardeep Mittal, Xiaoyi Min, Shella Keilholz, Liqing Yu, Gengshen Qin, Alton Brad Farris, Zhi-Ren Liu, and Jenny J. Yang

Subjects
Science
Abstract

Non-invasive early diagnosis of liver fibrosis is important to prevent disease progression and direct treatment strategies. Here the authors developed a collagen-targeting contrast agent for the detection of early stage fibrosis and non-alcoholic steatohepatitis by magnetic resonance and tested it in animal models.

Published
2019
Full Text
View/download PDF

2. Rational design of a protein that binds integrin αvβ3 outside the ligand binding site

Author

Ravi Chakra Turaga, Lu Yin, Jenny J. Yang, Hsiauwei Lee, Ivaylo Ivanov, Chunli Yan, Hua Yang, Hans E. Grossniklaus, Siming Wang, Cheng Ma, Li Sun, and Zhi-Ren Liu

Subjects
Science
Abstract

Integrins are transmembrane proteins that have important roles in cell adhesion and signalling. Here the authors design a therapeutic protein that binds integrin αvβ3, has anti-angiogenic activity, and reduces tumour growth in xenograft models, while being seemingly well tolerated.

Published
2016
Full Text
View/download PDF

3. Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis

Author

Xueliang Gao, Zhi-Ren Liu, Jenny J. Yang, and Haizhen Wang

Subjects
animal structures, Immunoprecipitation, Amino Acid Motifs, Molecular Sequence Data, General Physics and Astronomy, Biology, Microtubules, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, DEAD-box RNA Helicases, 03 medical and health sciences, Mice, 0302 clinical medicine, Calmodulin, Microtubule, Cell Movement, Cell Line, Tumor, Neoplasms, Gene Knockdown Techniques, Animals, Humans, Amino Acid Sequence, Neoplasm Metastasis, Peptide sequence, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Molecular Motor Proteins, Cell migration, General Chemistry, Molecular biology, RNA Helicase A, Xenograft Model Antitumor Assays, 3. Good health, Cell biology, Protein Transport, 030220 oncology & carcinogenesis, Calcium, Lamellipodium, Peptides, Filopodia, Protein Binding
Abstract

p68 RNA helicase is a prototypical RNA helicase. Here we present evidence to show that, by interacting with Ca-calmodulin, p68 has a role in cancer metastasis and cell migration. A peptide fragment that spans the IQ motif of p68 strongly inhibits cancer metastasis in two different animal models. The peptide interrupts p68 and Ca-calmodulin interaction and inhibits cell migration. Our results demonstrate that the p68-Ca-calmodulin interaction is essential for the formation of lamellipodia and filopodia in migrating cells. p68 interacts with microtubules in the presence of Ca-calmodulin. Our experiments show that interaction with microtubules stimulates p68 ATPase activity. Further, microtubule gliding assays demonstrate that p68, in the presence of Ca-calmodulin, can function as a microtubule motor. This motor activity may allow p68 to transport Ca-calmodulin to the leading edge of migrating cells.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results