1. Multiple common variants for celiac disease influencing immune gene expression
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Anna Rybak, Luigi Greco, Joseph A. Murray, Graham A. Heap, Katherine I. Morley, Maria Teresa Bardella, Päivi Saavalainen, Graham Turner, Jeffrey C. Barrett, Alexandra Zhernakova, Veikko Salomaa, Bárbara Dema, Róza Ádány, Lude Franke, Charles A. Mein, Owen T. McCann, Sarah E. Hunt, Roel A. Ophoff, Susan L. Neuhausen, Rudolf S N Fehrmann, Karen A. Hunt, Patrick Dubois, Kalle Kurppa, Roderick H. J. Houwen, Bożena Cukrowska, Nicholas A. Bockett, M. Luisa Mearin, Leena Peltonen, Elena Urcelay, Emilio G. de la Concha, Maria Cristina Mazzilli, Vanisha Mistry, Rinse K. Weersma, Concepción Núñez, Ross McManus, Harry J.M. Groen, Joachim J. Schweizer, Cisca Wijmenga, Gosia Trynka, Greetje J. Tack, Markku Mäki, Alessandra Curtotti, Rhian Gwilliam, Padraic MacMathuna, Maria Pia Sperandeo, Peter M. Green, David A. van Heel, Jihane Romanos, Dermot Kelleher, Ilma Rita Korponay-Szabó, Victorien M. Wolters, Isabel Polanco, Katri Kaukinen, Szilvia Fiatal, Elvira Grandone, Wieke H. M. Verbeek, Arpo Aromaa, Panos Deloukas, Leonard H. van den Berg, Elvira Oosterom, Barbara Mora, Donatella Barisani, Muddassar M. Mirza, Jan H. Veldink, Mathieu Platteel, Chris J. J. Mulder, Miguel Fernández-Arquero, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL), Gastroenterology and hepatology, CCA - Immuno-pathogenesis, Dubois, P, Trynka, G, Franke, L, Hunt, K, Romanos, J, Curtotti, A, Zhernakova, A, Heap, G, Adány, R, Aromaa, A, Bardella, M, van den Berg, L, Bockett, N, de la Concha, E, Dema, B, Fehrmann, R, Fernández Arquero, M, Fiatal, S, Grandone, E, Green, P, Groen, H, Gwilliam, R, Houwen, R, Hunt, S, Kaukinen, K, Kelleher, D, Korponay Szabo, I, Kurppa, K, Macmathuna, P, Mäki, M, Mazzilli, M, Mccann, O, Mearin, M, Mein, C, Mirza, M, Mistry, V, Mora, B, Morley, K, Mulder, C, Murray, J, Núñez, C, Oosterom, E, Ophoff, R, Polanco, I, Peltonen, L, Platteel, M, Rybak, A, Salomaa, V, Schweizer, J, Sperandeo, M, Tack, G, Turner, G, Veldink, J, Verbeek, W, Weersma, R, Wolters, V, Urcelay, E, Cukrowska, B, Greco, L, Neuhausen, S, Mcmanus, R, Barisani, D, Deloukas, P, Barrett, J, Saavalainen, P, Wijmenga, C, and van Heel, D
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POSITIVE SELECTION ,HETERODIMER ,Genes, MHC Class I ,Gene Expression ,Genome-wide association study ,Medical and Health Sciences ,MHC Class I ,0302 clinical medicine ,Immunopathology ,RISK VARIANTS ,2.1 Biological and endogenous factors ,Aetiology ,POPULATION ,Genetics ,0303 health sciences ,education.field_of_study ,THYMUS ,Orvostudományok ,Single Nucleotide ,THYMOCYTES ,Biological Sciences ,3. Good health ,030220 oncology & carcinogenesis ,Egészségtudományok ,Human ,Biotechnology ,Risk ,SUSCEPTIBILITY LOCI ,Population ,Single-nucleotide polymorphism ,CLEC16A ,Quantitative trait locus ,Biology ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,Meta-Analysis as Topic ,Humans ,Allele ,GENOME-WIDE ASSOCIATION ,Polymorphism ,education ,030304 developmental biology ,Gene Expression Profiling ,Human Genome ,BIO/13 - BIOLOGIA APPLICATA ,ALLELES ,RHEUMATOID-ARTHRITIS ,Gene expression profiling ,Celiac Disease ,Genes ,Case-Control Studies ,genome-wide association rheumatoid-arthritis susceptibility loci positive selection risk variants population alleles thymus heterodimer thymocytes ,Digestive Diseases ,Genome-Wide Association Study ,Developmental Biology - Abstract
We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS)
- Published
- 2010
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