1. Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restriction
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Anne C. Ferguson-Smith, Marika Charalambous, Nozomi Takahashi, Steven R. Bauer, Ulla Sovio, Claire L Dent, Mary Ann Megan Cleaton, D Steven Charnock-Jones, Isabelle Gutteridge, Gordon C. S. Smith, Jennifer A. Corish, Francesca Gaccioli, Mark Howard, Theresa L. Powell, Sovio, Ulla [0000-0002-0799-1105], Gaccioli, Francesca [0000-0001-7178-8921], Takahashi, Nozomi [0000-0002-4267-1094], Charnock-Jones, Stephen [0000-0002-2936-4890], Smith, Gordon [0000-0003-2124-0997], Ferguson-Smith, Anne [0000-0003-4996-9990], and Apollo - University of Cambridge Repository
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0301 basic medicine ,medicine.medical_specialty ,Physiology ,Gestational Age ,Biology ,Article ,Fetal Growth Retardation/blood ,Cohort Studies ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Fetus ,Pregnancy ,Health care ,Genetics ,Fetal growth ,medicine ,Animals ,Humans ,Infant, Small for Gestational Age/blood ,030219 obstetrics & reproductive medicine ,Fetal Growth Retardation ,business.industry ,Fetus/metabolism ,Calcium-Binding Proteins ,Infant, Newborn ,Membrane Proteins ,medicine.disease ,Pregnancy Complications/blood ,Adaptation, Physiological ,Pregnancy Complications ,030104 developmental biology ,Research centre ,Family medicine ,Donation ,Case-Control Studies ,Intercellular Signaling Peptides and Proteins/blood ,Infant, Small for Gestational Age ,Intercellular Signaling Peptides and Proteins ,Female ,Neonatal death ,business ,Outcome prediction ,Biomarkers/blood ,Biomarkers ,Cohort study - Abstract
M.A.M.C. was supported by a PhD studentship from the Cambridge Centre for Trophoblast Research. Research was supported by grants from the MRC (MR/J001597/1 and MR/L002345/1), the Medical College of Saint Bartholomew's Hospital Trust, a Wellcome Trust Investigator Award, EpigeneSys (FP7 Health-257082), EpiHealth (FP7 Health-278414), a Herchel Smith Fellowship (N.T.) and NIH grant RO1 DK89989. The contents are the authors' sole responsibility and do not necessarily represent official NIH views. We thank G. Burton for invaluable support, and M. Constância and I. Sandovici (University of Cambridge) for the Meox2-cre mice. We are extremely grateful to all of the participants in the Pregnancy Outcome Prediction study. This work was supported by the NIHR Cambridge Comprehensive Biomedical Research Centre (Women's Health theme) and project grants from the MRC (G1100221) and Sands (Stillbirth and Neonatal Death Charity). The study was also supported by GE Healthcare (donation of two Voluson i ultrasound systems for this study) and by the NIHR Cambridge Clinical Research Facility, where all research visits took place.
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- 2016
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