1. Identification of erythroferrone as an erythroid regulator of iron metabolism
- Author
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Kautz, Léon, Jung, Grace, Valore, Erika V, Rivella, Stefano, Nemeth, Elizabeta, and Ganz, Tomas
- Subjects
Cooley's Anemia ,Hematology ,Rare Diseases ,Liver Disease ,Digestive Diseases ,Blood ,Anemia ,Animals ,Blotting ,Western ,Disease Models ,Animal ,Enzyme-Linked Immunosorbent Assay ,Epoetin Alfa ,Erythropoiesis ,Erythropoietin ,Gene Expression Profiling ,Hemoglobins ,Hemorrhage ,Hepcidins ,Hormones ,Iron ,Iron Overload ,Liver ,Male ,Mice ,Mice ,Inbred C57BL ,Mice ,Knockout ,Molecular Sequence Data ,RNA ,Messenger ,Real-Time Polymerase Chain Reaction ,Recombinant Proteins ,Reverse Transcriptase Polymerase Chain Reaction ,beta-Thalassemia ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
Recovery from blood loss requires a greatly enhanced supply of iron to support expanded erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin allows increased iron absorption and mobilization from stores. We identified a new hormone, erythroferrone (ERFE), that mediates hepcidin suppression during stress erythropoiesis. ERFE is produced by erythroblasts in response to erythropoietin. ERFE-deficient mice fail to suppress hepcidin rapidly after hemorrhage and exhibit a delay in recovery from blood loss. ERFE expression is greatly increased in Hbb(th3/+) mice with thalassemia intermedia, where it contributes to the suppression of hepcidin and the systemic iron overload characteristic of this disease.
- Published
- 2014