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Your search keyword '"Ryan L, Minster"' showing total 3 results
Start Over Author "Ryan L, Minster" Journal nature genetics
3 results on '"Ryan L, Minster"'

1. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Author

Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel I. Chasman, Sameer Chavan, Yii-Der I. Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi’a Sefuiva Reupena, Stephen S. Rich, Jerome I. Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H. Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, and Dajiang J. Liu

Subjects
Tobacco Smoke and Health, Human Genome, Drug Repositioning, Single Nucleotide, Biological Sciences, Medical and Health Sciences, Brain Disorders, Tobacco Use, Substance Misuse, Good Health and Well Being, Tobacco, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Transcriptome, Drug Abuse (NIDA only), Biology, Genome-Wide Association Study, Developmental Biology
Abstract

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quantitative trait locus (eQTL) data from diverse ancestries. We developed a new approach, TESLA (multi-ancestry integrative study using an optimal linear combination of association statistics), to integrate an eQTL dataset with a multi-ancestry GWAS. By exploiting shared phenotypic effects between ancestries and accommodating potential effect heterogeneities, TESLA improves power over other TWAS methods. When applied to tobacco use phenotypes, TESLA identified 273 new genes, up to 55% more compared with alternative TWAS methods. These hits and subsequent fine mapping using TESLA point to target genes with biological relevance. In silico drug-repurposing analyses highlight several drugs with known efficacy, including dextromethorphan and galantamine, and new drugs such as muscle relaxants that may be repurposed for treating nicotine addiction.

Published
2023
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2. A thrifty variant in CREBRF strongly influences body mass index in Samoans

Author

Olive D. Buhule, Daniel E. Weeks, Muagututi‘a Sefuiva Reupena, Take Naseri, Erin E. Kershaw, Chi-Ting Su, Zsolt Urban, Hong Cheng, Nicola L. Hawley, Ranjan Deka, Ryan L. Minster, Jerome Lin, Stephen T. McGarvey, Guangyun Sun, Satupa‘itea Viali, and John Tuitele

Subjects
Adult, 0301 basic medicine, Genotype, Samoa, Mutation, Missense, Common Obesity, Energy metabolism, 030209 endocrinology & metabolism, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Article, Body Mass Index, 03 medical and health sciences, Tumor suppressor proteins, 0302 clinical medicine, Genetics, medicine, Humans, Genetic Predisposition to Disease, Longitudinal Studies, Obesity, Tumor Suppressor Proteins, medicine.disease, 030104 developmental biology, Energy Metabolism, Body mass index, Genome-Wide Association Study
Abstract

Samoans are a unique founder population with a high prevalence of obesity, making them well suited for identifying new genetic contributors to obesity. We conducted a genome-wide association study (GWAS) in 3,072 Samoans, discovered a variant, rs12513649, strongly associated with body mass index (BMI) (P = 5.3 × 10(-14)), and replicated the association in 2,102 additional Samoans (P = 1.2 × 10(-9)). Targeted sequencing identified a strongly associated missense variant, rs373863828 (p.Arg457Gln), in CREBRF (meta P = 1.4 × 10(-20)). Although this variant is extremely rare in other populations, it is common in Samoans (frequency of 0.259), with an effect size much larger than that of any other known common BMI risk variant (1.36-1.45 kg/m(2) per copy of the risk-associated allele). In comparison to wild-type CREBRF, the Arg457Gln variant when overexpressed selectively decreased energy use and increased fat storage in an adipocyte cell model. These data, in combination with evidence of positive selection of the allele encoding p.Arg457Gln, support a 'thrifty' variant hypothesis as a factor in human obesity.

Published
2016
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3. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Wenbo Tang, Stephen B. Kritchevsky, Ian P. Hall, Alexessander Couto Alves, Henry Völzke, Kim de Jong, Sina A. Gharib, Louise V. Wain, Adaikalavan Ramasamy, John M. Starr, Tatijana Zemunik, André G. Uitterlinden, Isabelle Pin, A. Bill Musk, Lina Zgaga, Ernst Omenaas, Mi Kyeong Lee, Nadia N. Hansel, Lewis J. Smith, Dana B. Hancock, Anne Viljanen, Anneli Pouta, Erik Melén, Nora Franceschini, Susan Campbell, Alicja R. Rudnicka, Melissa E. Garcia, Jemma B. Wilk, Igor Rudan, John Beilby, Fernando Rivadeneira, Gudny Eiriksdottir, Lenore J. Launer, Kristin M. Burkart, Ozren Polasek, Pieter S. Hiemstra, Regina Hampel, Jerome I. Rotter, Markku Heliövaara, Harald Grallert, Tim D. Spector, Andrew P. Morris, Jennifer E. Huffman, Pau Navarro, Jing Hua Zhao, Robert A. Scott, Bruno H. Stricker, Christopher Oldmeadow, Yeon-Mok Oh, Christian Gieger, Tove Fall, Caroline Hayward, Rodney J. Scott, Mika Kähönen, Vilmundur Gudnason, Guy Brusselle, Stefan Karrasch, Anne B. Newman, Alan James, Ida Surakka, Peter K. Joshi, R. Graham Barr, Fien Verhamme, Alexander Teumer, Ulf Gyllensten, Joohon Sung, Marjolein J. Peters, Ryan L. Minster, Kirsi H. Pietiläinen, Ian J. Deary, Lorna M. Lopez, Matthias Wjst, Myriam Fornage, Susan Redline, Wei Gao, Taina Rantanen, David J. Lederer, Gail Davies, Mary K. Wojczynski, Kari E. North, Beate Koch, Guo Li, George T. O'Connor, Blair H. Smith, Harry Campbell, Wendy B. White, Juha Pekkanen, Eva Albrecht, Sven Gläser, Joyce B. J. van Meurs, Stephen S. Rich, Wendy L. McArdle, Deborah Jarvis, Ani Manichaikul, Pirro G. Hysi, Christopher J Hammond, Erik Ingelsson, Albert V. Smith, John Attia, O. Dale Williams, Tamara B. Harris, Susan R. Heckbert, Josée Dupuis, Bruce M. Psaty, Åsa Johansson, Xin-Qun Wang, Samuli Ripatti, Woo Jin Kim, Patricia A. Cassano, H. Marike Boezen, David J. Porteous, Esteban G. Burchard, Kurt Lohman, Ivana Kolcic, Lies Lahousse, James F. Wilson, Dirkje S. Postma, Holly Trochet, Nicholas J. Wareham, Ana Viñuela, María Soler Artigas, Lars Lind, Jennie Hui, Bharat Thyagarajan, Judith M. Vonk, Marcy F. Petrini, Bonnie R. Joubert, Marjo-Riitta Järvelin, Xiangjun Gu, Claudia Flexeder, Generation Scotland, Sarah H. Wild, Nicholas D. Hastie, Thomas Lumley, Veronique Vitart, Laura R. Loehr, Joachim Heinrich, Yongmei Liu, Akshay Sood, Tess D. Pottinger, Alan F. Wright, Albert Hofman, Rajesh Kumar, Cisca Wijmenga, Elizabeth G. Holliday, Ian Sayers, David P. Strachan, Martin D. Tobin, Stefan Enroth, Thor Aspelund, Leslie A. Lange, Qing Duan, Daan W. Loth, Ken R. Bracke, Nathan C. Gaddis, David Couper, Stephanie J. London, Alanna C. Morrison, Holger Schulz, Jaakko Kaprio, Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Otorhinolaryngology and Head and Neck Surgery, Psychiatry, Epidemiology, Public Health, and Internal Medicine

Subjects
Spirometry, Lung Diseases, Vital capacity, Quantitative Trait Loci, Vital Capacity, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Article, DISEASE, Pulmonary function testing, Cohort Studies, FEV1/FVC ratio, Idiopathic pulmonary fibrosis, SDG 3 - Good Health and Well-being, Meta-Analysis as Topic, Forced Expiratory Volume, Databases, Genetic, Genetics, medicine, Humans, Restrictive lung disease, Lung volumes, Genetic Predisposition to Disease, lung, spriometry, SNP, gene, GENE-EXPRESSION, medicine.diagnostic_test, Genome, Human, HERITABILITY, HEALTHY TWIN, MORTALITY, ta3141, respiratory system, medicine.disease, Prognosis, 3. Good health, Respiratory Function Tests, respiratory tract diseases, FAMILY, LUNG-FUNCTION, Genetic Loci, Immunology, CELLS, IDIOPATHIC PULMONARY-FIBROSIS, TRAITS, Follow-Up Studies, Genome-Wide Association Study
Abstract

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P

Published
2014
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