145 results on '"Steinthorsdottir, Valgerdur"'
Search Results
2. Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage
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Westergaard, David, Steinthorsdottir, Valgerdur, Stefansdottir, Lilja, Rohde, Palle Duun, Wu, Xiaoping, Geller, Frank, Tyrmi, Jaakko, Havulinna, Aki S., Solé-Navais, Pol, Flatley, Christopher, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Erikstrup, Christian, Sørensen, Erik, Mikkelsen, Christina, Bruun, Mie Topholm, Aagaard Jensen, Bitten, Brodersen, Thorsten, Ullum, Henrik, Magnus, Per, Andreassen, Ole A., Njolstad, Pål R., Kolte, Astrid Marie, Krebs, Lone, Nyegaard, Mette, Hansen, Thomas Folkmann, Feenstra, Bjarke, Daly, Mark, Lindgren, Cecilia M., Thorleifsson, Gudmar, Stefansson, Olafur A., Sveinbjornsson, Gardar, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Banasik, Karina, Jacobsson, Bo, Laisk, Triin, Laivuori, Hannele, Stefansson, Kari, Brunak, Søren, and Nielsen, Henriette Svarre
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- 2024
- Full Text
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3. GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
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Lagou, Vasiliki, Jiang, Longda, Ulrich, Anna, Zudina, Liudmila, González, Karla Sofia Gutiérrez, Balkhiyarova, Zhanna, Faggian, Alessia, Maina, Jared G., Chen, Shiqian, Todorov, Petar V., Sharapov, Sodbo, David, Alessia, Marullo, Letizia, Mägi, Reedik, Rujan, Roxana-Maria, Ahlqvist, Emma, Thorleifsson, Gudmar, Gao, Ηe, Εvangelou, Εvangelos, Benyamin, Beben, Scott, Robert A., Isaacs, Aaron, Zhao, Jing Hua, Willems, Sara M., Johnson, Toby, Gieger, Christian, Grallert, Harald, Meisinger, Christa, Müller-Nurasyid, Martina, Strawbridge, Rona J., Goel, Anuj, Rybin, Denis, Albrecht, Eva, Jackson, Anne U., Stringham, Heather M., Corrêa, Jr., Ivan R., Farber-Eger, Eric, Steinthorsdottir, Valgerdur, Uitterlinden, André G., Munroe, Patricia B., Brown, Morris J., Schmidberger, Julian, Holmen, Oddgeir, Thorand, Barbara, Hveem, Kristian, Wilsgaard, Tom, Mohlke, Karen L., Wang, Zhe, Shmeliov, Aleksey, den Hoed, Marcel, Loos, Ruth J. F., Kratzer, Wolfgang, Haenle, Mark, Koenig, Wolfgang, Boehm, Bernhard O., Tan, Tricia M., Tomas, Alejandra, Salem, Victoria, Barroso, Inês, Tuomilehto, Jaakko, Boehnke, Michael, Florez, Jose C., Hamsten, Anders, Watkins, Hugh, Njølstad, Inger, Wichmann, H.-Erich, Caulfield, Mark J., Khaw, Kay-Tee, van Duijn, Cornelia M., Hofman, Albert, Wareham, Nicholas J., Langenberg, Claudia, Whitfield, John B., Martin, Nicholas G., Montgomery, Grant, Scapoli, Chiara, Tzoulaki, Ioanna, Elliott, Paul, Thorsteinsdottir, Unnur, Stefansson, Kari, Brittain, Evan L., McCarthy, Mark I., Froguel, Philippe, Sexton, Patrick M., Wootten, Denise, Groop, Leif, Dupuis, Josée, Meigs, James B., Deganutti, Giuseppe, Demirkan, Ayse, Pers, Tune H., Reynolds, Christopher A., Aulchenko, Yurii S., Kaakinen, Marika A., Jones, Ben, and Prokopenko, Inga
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- 2023
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4. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
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Mahajan, Anubha, Spracklen, Cassandra N, Zhang, Weihua, Ng, Maggie CY, Petty, Lauren E, Kitajima, Hidetoshi, Yu, Grace Z, Rüeger, Sina, Speidel, Leo, Kim, Young Jin, Horikoshi, Momoko, Mercader, Josep M, Taliun, Daniel, Moon, Sanghoon, Kwak, Soo-Heon, Robertson, Neil R, Rayner, Nigel W, Loh, Marie, Kim, Bong-Jo, Chiou, Joshua, Miguel-Escalada, Irene, della Briotta Parolo, Pietro, Lin, Kuang, Bragg, Fiona, Preuss, Michael H, Takeuchi, Fumihiko, Nano, Jana, Guo, Xiuqing, Lamri, Amel, Nakatochi, Masahiro, Scott, Robert A, Lee, Jung-Jin, Huerta-Chagoya, Alicia, Graff, Mariaelisa, Chai, Jin-Fang, Parra, Esteban J, Yao, Jie, Bielak, Lawrence F, Tabara, Yasuharu, Hai, Yang, Steinthorsdottir, Valgerdur, Cook, James P, Kals, Mart, Grarup, Niels, Schmidt, Ellen M, Pan, Ian, Sofer, Tamar, Wuttke, Matthias, Sarnowski, Chloe, Gieger, Christian, Nousome, Darryl, Trompet, Stella, Long, Jirong, Sun, Meng, Tong, Lin, Chen, Wei-Min, Ahmad, Meraj, Noordam, Raymond, Lim, Victor JY, Tam, Claudia HT, Joo, Yoonjung Yoonie, Chen, Chien-Hsiun, Raffield, Laura M, Lecoeur, Cécile, Prins, Bram Peter, Nicolas, Aude, Yanek, Lisa R, Chen, Guanjie, Jensen, Richard A, Tajuddin, Salman, Kabagambe, Edmond K, An, Ping, Xiang, Anny H, Choi, Hyeok Sun, Cade, Brian E, Tan, Jingyi, Flanagan, Jack, Abaitua, Fernando, Adair, Linda S, Adeyemo, Adebowale, Aguilar-Salinas, Carlos A, Akiyama, Masato, Anand, Sonia S, Bertoni, Alain, Bian, Zheng, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A, Brummett, Chad M, Buchanan, Thomas A, Canouil, Mickaël, Chan, Juliana CN, Chang, Li-Ching, Chee, Miao-Li, Chen, Ji, Chen, Shyh-Huei, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, and Cushman, Mary
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Genetics ,Diabetes ,Human Genome ,Metabolic and endocrine ,Diabetes Mellitus ,Type 2 ,Ethnicity ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Polymorphism ,Single Nucleotide ,Risk Factors ,FinnGen ,eMERGE Consortium ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P 50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background.
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- 2022
5. Genetic effects on the timing of parturition and links to fetal birth weight
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Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina, Srivastava, Amit, Talbot, Octavious, Allard, Catherine, Williams, Scott M., Menon, Ramkumar, Shields, Beverley M., Sveinbjornsson, Gardar, Xu, Huan, Melbye, Mads, Lowe, Jr, William, Bouchard, Luigi, Oken, Emily, Pedersen, Ole B., Gudbjartsson, Daniel F., Erikstrup, Christian, Sørensen, Erik, Lie, Rolv T., Teramo, Kari, Hallman, Mikko, Juliusdottir, Thorhildur, Hakonarson, Hakon, Ullum, Henrik, Hattersley, Andrew T., Sletner, Line, Merialdi, Mario, Rifas-Shiman, Sheryl L., Steingrimsdottir, Thora, Scholtens, Denise, Power, Christine, West, Jane, Nyegaard, Mette, Capra, John A., Skogholt, Anne H., Magnus, Per, Andreassen, Ole A., Thorsteinsdottir, Unnur, Grant, Struan F. A., Qvigstad, Elisabeth, Pennell, Craig E., Hivert, Marie-France, Hayes, Geoffrey M., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Lawlor, Deborah A., Nielsen, Henriette S., Mägi, Reedik, Rokas, Antonis, Hveem, Kristian, Stefansson, Kari, Feenstra, Bjarke, Njolstad, Pål, Muglia, Louis J., Freathy, Rachel M., Johansson, Stefan, Zhang, Ge, and Jacobsson, Bo
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- 2023
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6. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions
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Rahmioglu, Nilufer, Mortlock, Sally, Ghiasi, Marzieh, Møller, Peter L., Stefansdottir, Lilja, Galarneau, Geneviève, Turman, Constance, Danning, Rebecca, Law, Matthew H., Sapkota, Yadav, Christofidou, Paraskevi, Skarp, Sini, Giri, Ayush, Banasik, Karina, Krassowski, Michal, Lepamets, Maarja, Marciniak, Błażej, Nõukas, Margit, Perro, Danielle, Sliz, Eeva, Sobalska-Kwapis, Marta, Thorleifsson, Gudmar, Topbas-Selcuki, Nura F., Vitonis, Allison, Westergaard, David, Arnadottir, Ragnheidur, Burgdorf, Kristoffer S., Campbell, Archie, Cheuk, Cecilia S. K., Clementi, Caterina, Cook, James, De Vivo, Immaculata, DiVasta, Amy, Dorien, O., Donoghue, Jacqueline F., Edwards, Todd, Fontanillas, Pierre, Fung, Jenny N., Geirsson, Reynir T., Girling, Jane E., Harkki, Paivi, Harris, Holly R., Healey, Martin, Heikinheimo, Oskari, Holdsworth-Carson, Sarah, Hostettler, Isabel C., Houlden, Henry, Houshdaran, Sahar, Irwin, Juan C., Jarvelin, Marjo-Riitta, Kamatani, Yoichiro, Kennedy, Stephen H., Kepka, Ewa, Kettunen, Johannes, Kubo, Michiaki, Kulig, Bartosz, Kurra, Venla, Laivuori, Hannele, Laufer, Marc R., Lindgren, Cecilia M., MacGregor, Stuart, Mangino, Massimo, Martin, Nicholas G., Matalliotaki, Charoula, Matalliotakis, Michail, Murray, Alison D., Ndungu, Anne, Nezhat, Camran, Olsen, Catherine M., Opoku-Anane, Jessica, Padmanabhan, Sandosh, Paranjpe, Manish, Peters, Maire, Polak, Grzegorz, Porteous, David J., Rabban, Joseph, Rexrode, Kathyrn M., Romanowicz, Hanna, Saare, Merli, Saavalainen, Liisu, Schork, Andrew J., Sen, Sushmita, Shafrir, Amy L., Siewierska-Górska, Anna, Słomka, Marcin, Smith, Blair H., Smolarz, Beata, Szaflik, Tomasz, Szyłło, Krzysztof, Takahashi, Atsushi, Terry, Kathryn L., Tomassetti, Carla, Treloar, Susan A., Vanhie, Arne, Vincent, Katy, Vo, Kim C., Werring, David J., Zeggini, Eleftheria, Zervou, Maria I., Adachi, Sosuke, Buring, Julie E., Ridker, Paul M., D’Hooghe, Thomas, Goulielmos, George N., Hapangama, Dharani K., Hayward, Caroline, Horne, Andrew W., Low, Siew-Kee, Martikainen, Hannu, Chasman, Daniel I., Rogers, Peter A. W., Saunders, Philippa T., Sirota, Marina, Spector, Tim, Strapagiel, Dominik, Tung, Joyce Y., Whiteman, David C., Giudice, Linda C., Velez-Edwards, Digna R., Uimari, Outi, Kraft, Peter, Salumets, Andres, Nyholt, Dale R., Mägi, Reedik, Stefansson, Kari, Becker, Christian M., Yurttas-Beim, Piraye, Steinthorsdottir, Valgerdur, Nyegaard, Mette, Missmer, Stacey A., Montgomery, Grant W., Morris, Andrew P., and Zondervan, Krina T.
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- 2023
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7. Multiomics study of nonalcoholic fatty liver disease
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Sveinbjornsson, Gardar, Ulfarsson, Magnus O., Thorolfsdottir, Rosa B., Jonsson, Benedikt A., Einarsson, Eythor, Gunnlaugsson, Gylfi, Rognvaldsson, Solvi, Arnar, David O., Baldvinsson, Magnus, Bjarnason, Ragnar G., Eiriksdottir, Thjodbjorg, Erikstrup, Christian, Ferkingstad, Egil, Halldorsson, Gisli H., Helgason, Hannes, Helgadottir, Anna, Hindhede, Lotte, Hjorleifsson, Grimur, Jones, David, Knowlton, Kirk U., Lund, Sigrun H., Melsted, Pall, Norland, Kristjan, Olafsson, Isleifur, Olafsson, Sigurdur, Oskarsson, Gudjon R., Ostrowski, Sisse Rye, Pedersen, Ole Birger, Snaebjarnarson, Auðunn S., Sigurdsson, Emil, Steinthorsdottir, Valgerdur, Schwinn, Michael, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Bundgaard, Henning, Nadauld, Lincoln, Bjornsson, Einar S., Rulifson, Ingrid C., Rafnar, Thorunn, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, Gudbjartsson, Daniel F., Holm, Hilma, and Stefansson, Kari
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- 2022
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8. Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight
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Solé-Navais, Pol, Flatley, Christopher, Steinthorsdottir, Valgerdur, Vaudel, Marc, Juodakis, Julius, Chen, Jing, Laisk, Triin, LaBella, Abigail L., Westergaard, David, Bacelis, Jonas, Brumpton, Ben, Skotte, Line, Borges, Maria C., Helgeland, Øyvind, Mahajan, Anubha, Wielscher, Matthias, Lin, Frederick, Briggs, Catherine, Wang, Carol A., Moen, Gunn-Helen, Beaumont, Robin N., Bradfield, Jonathan P., Abraham, Abin, Thorleifsson, Gudmar, Gabrielsen, Maiken E., Ostrowski, Sisse R., Modzelewska, Dominika, Nohr, Ellen A., Hypponen, Elina, Srivastava, Amit, Talbot, Octavious, Allard, Catherine, Williams, Scott M., Menon, Ramkumar, Shields, Beverley M., Sveinbjornsson, Gardar, Xu, Huan, Melbye, Mads, Lowe, Jr, William, Bouchard, Luigi, Oken, Emily, Pedersen, Ole B., Gudbjartsson, Daniel F., Erikstrup, Christian, Sørensen, Erik, Lie, Rolv T., Teramo, Kari, Hallman, Mikko, Juliusdottir, Thorhildur, Hakonarson, Hakon, Ullum, Henrik, Hattersley, Andrew T., Sletner, Line, Merialdi, Mario, Rifas-Shiman, Sheryl L., Steingrimsdottir, Thora, Scholtens, Denise, Power, Christine, West, Jane, Nyegaard, Mette, Capra, John A., Skogholt, Anne H., Magnus, Per, Andreassen, Ole A., Thorsteinsdottir, Unnur, Grant, Struan F. A., Qvigstad, Elisabeth, Pennell, Craig E., Hivert, Marie-France, Hayes, Geoffrey M., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Lawlor, Deborah A., Nielsen, Henriette S., Mägi, Reedik, Rokas, Antonis, Hveem, Kristian, Stefansson, Kari, Feenstra, Bjarke, Njolstad, Pål, Muglia, Louis J., Freathy, Rachel M., Johansson, Stefan, Zhang, Ge, and Jacobsson, Bo
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- 2023
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9. Large-scale integration of the plasma proteome with genetics and disease
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Ferkingstad, Egil, Sulem, Patrick, Atlason, Bjarni A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Styrmisdottir, Edda L., Gunnarsdottir, Kristbjorg, Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Bjarni V., Jensson, Brynjar O., Zink, Florian, Halldorsson, Gisli H., Masson, Gisli, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Juliusson, Kristinn, Magnusson, Magnus K., Magnusson, Olafur Th., Fridriksdottir, Run, Saevarsdottir, Saedis, Gudjonsson, Sigurjon A., Stacey, Simon N., Rognvaldsson, Solvi, Eiriksdottir, Thjodbjorg, Olafsdottir, Thorunn A., Steinthorsdottir, Valgerdur, Tragante, Vinicius, Ulfarsson, Magnus O., Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Lund, Sigrun H., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2021
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10. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
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Mahajan, Anubha, Wessel, Jennifer, Willems, Sara M, Zhao, Wei, Robertson, Neil R, Chu, Audrey Y, Gan, Wei, Kitajima, Hidetoshi, Taliun, Daniel, Rayner, N William, Guo, Xiuqing, Lu, Yingchang, Li, Man, Jensen, Richard A, Hu, Yao, Huo, Shaofeng, Lohman, Kurt K, Zhang, Weihua, Cook, James P, Prins, Bram Peter, Flannick, Jason, Grarup, Niels, Trubetskoy, Vassily Vladimirovich, Kravic, Jasmina, Kim, Young Jin, Rybin, Denis V, Yaghootkar, Hanieh, Müller-Nurasyid, Martina, Meidtner, Karina, Li-Gao, Ruifang, Varga, Tibor V, Marten, Jonathan, Li, Jin, Smith, Albert Vernon, An, Ping, Ligthart, Symen, Gustafsson, Stefan, Malerba, Giovanni, Demirkan, Ayse, Tajes, Juan Fernandez, Steinthorsdottir, Valgerdur, Wuttke, Matthias, Lecoeur, Cécile, Preuss, Michael, Bielak, Lawrence F, Graff, Marielisa, Highland, Heather M, Justice, Anne E, Liu, Dajiang J, Marouli, Eirini, Peloso, Gina Marie, Warren, Helen R, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Afaq, Saima, Afzal, Shoaib, Ahlqvist, Emma, Almgren, Peter, Amin, Najaf, Bang, Lia B, Bertoni, Alain G, Bombieri, Cristina, Bork-Jensen, Jette, Brandslund, Ivan, Brody, Jennifer A, Burtt, Noël P, Canouil, Mickaël, Chen, Yii-Der Ida, Cho, Yoon Shin, Christensen, Cramer, Eastwood, Sophie V, Eckardt, Kai-Uwe, Fischer, Krista, Gambaro, Giovanni, Giedraitis, Vilmantas, Grove, Megan L, de Haan, Hugoline G, Hackinger, Sophie, Hai, Yang, Han, Sohee, Tybjærg-Hansen, Anne, Hivert, Marie-France, Isomaa, Bo, Jäger, Susanne, Jørgensen, Marit E, Jørgensen, Torben, Käräjämäki, Annemari, Kim, Bong-Jo, Kim, Sung Soo, Koistinen, Heikki A, Kovacs, Peter, Kriebel, Jennifer, Kronenberg, Florian, Läll, Kristi, Lange, Leslie A, Lee, Jung-Jin, Lehne, Benjamin, Li, Huaixing, and Lin, Keng-Hung
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ExomeBP Consortium ,MAGIC Consortium ,GIANT Consortium ,Humans ,Diabetes Mellitus ,Type 2 ,Genetic Predisposition to Disease ,Chromosome Mapping ,Alleles ,European Continental Ancestry Group ,Female ,Male ,Genetic Variation ,Genome-Wide Association Study ,Whole Exome Sequencing ,Diabetes Mellitus ,Type 2 ,Developmental Biology ,Biological Sciences ,Medical and Health Sciences - Abstract
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P
- Published
- 2018
11. Homozygosity for a stop-gain variant in CCDC201causes primary ovarian insufficiency
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Oddsson, Asmundur, Steinthorsdottir, Valgerdur, Oskarsson, Gudjon R., Styrkarsdottir, Unnur, Moore, Kristjan H. S., Isberg, Salvor, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Westergaard, David, Nielsen, Henriette Svarre, Fridriksdottir, Run, Jensson, Brynjar O., Arnadottir, Gudny A., Jonsson, Hakon, Sturluson, Arni, Snaebjarnarson, Audunn S., Andreassen, Ole A., Walters, G. Bragi, Nyegaard, Mette, Erikstrup, Christian, Steingrimsdottir, Thora, Lie, Rolv T., Melsted, Pall, Jonsdottir, Ingileif, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Saemundsdottir, Jona, Magnusson, Olafur Th., Banasik, Karina, Sorensen, Erik, Masson, Gisli, Pedersen, Ole Birger, Tryggvadottir, Laufey, Haavik, Jan, Ostrowski, Sisse Rye, Stefansson, Hreinn, Holm, Hilma, Rafnar, Thorunn, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
- Abstract
Age at menopause (AOM) has a substantial impact on fertility and disease risk. While many loci with variants that associate with AOM have been identified through genome-wide association studies (GWAS) under an additive model, other genetic models are rarely considered1. Here through GWAS meta-analysis under the recessive model of 174,329 postmenopausal women from Iceland, Denmark, the United Kingdom (UK; UK Biobank) and Norway, we study low-frequency variants with a large effect on AOM. We discovered that women homozygous for the stop-gain variant rs117316434(A) in CCDC201(p.(Arg162Ter), minor allele frequency ~1%) reached menopause 9 years earlier than other women (P= 1.3 × 10−15). The genotype is present in one in 10,000 northern European women and leads to primary ovarian insufficiency in close to half of them. Consequently, homozygotes have fewer children, and the age at last childbirth is 5 years earlier (P= 3.8 × 10−5). The CCDC201gene was only found in humans in 2022 and is highly expressed in oocytes. Homozygosity for CCDC201loss-of-function has a substantial impact on female reproductive health, and homozygotes would benefit from reproductive counseling and treatment for symptoms of early menopause.
- Published
- 2024
- Full Text
- View/download PDF
12. Distinction between the effects of parental and fetal genomes on fetal growth
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Juliusdottir, Thorhildur, Steinthorsdottir, Valgerdur, Stefansdottir, Lilja, Sveinbjornsson, Gardar, Ivarsdottir, Erna V., Thorolfsdottir, Rosa B., Sigurdsson, Jon K., Tragante, Vinicius, Hjorleifsson, Kristjan E., Helgadottir, Anna, Frigge, Michael L., Thorgeirsson, Gudmundur, Benediktsson, Rafn, Sigurdsson, Emil L., Arnar, David O., Steingrimsdottir, Thora, Jonsdottir, Ingileif, Holm, Hilma, Gudbjartsson, Daniel F., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2021
- Full Text
- View/download PDF
13. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
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Gaulton, Kyle J, Ferreira, Teresa, Lee, Yeji, Raimondo, Anne, Mägi, Reedik, Reschen, Michael E, Mahajan, Anubha, Locke, Adam, William Rayner, N, Robertson, Neil, Scott, Robert A, Prokopenko, Inga, Scott, Laura J, Green, Todd, Sparso, Thomas, Thuillier, Dorothee, Yengo, Loic, Grallert, Harald, Wahl, Simone, Frånberg, Mattias, Strawbridge, Rona J, Kestler, Hans, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Karssen, Lennart C, van Leeuwen, Elisabeth M, Willems, Sara M, Li, Man, Chen, Han, Fuchsberger, Christian, Kwan, Phoenix, Ma, Clement, Linderman, Michael, Lu, Yingchang, Thomsen, Soren K, Rundle, Jana K, Beer, Nicola L, van de Bunt, Martijn, Chalisey, Anil, Kang, Hyun Min, Voight, Benjamin F, Abecasis, Gonçalo R, Almgren, Peter, Baldassarre, Damiano, Balkau, Beverley, Benediktsson, Rafn, Blüher, Matthias, Boeing, Heiner, Bonnycastle, Lori L, Bottinger, Erwin P, Burtt, Noël P, Carey, Jason, Charpentier, Guillaume, Chines, Peter S, Cornelis, Marilyn C, Couper, David J, Crenshaw, Andrew T, van Dam, Rob M, Doney, Alex SF, Dorkhan, Mozhgan, Edkins, Sarah, Eriksson, Johan G, Esko, Tonu, Eury, Elodie, Fadista, João, Flannick, Jason, Fontanillas, Pierre, Fox, Caroline, Franks, Paul W, Gertow, Karl, Gieger, Christian, Gigante, Bruna, Gottesman, Omri, Grant, George B, Grarup, Niels, Groves, Christopher J, Hassinen, Maija, Have, Christian T, Herder, Christian, Holmen, Oddgeir L, Hreidarsson, Astradur B, Humphries, Steve E, Hunter, David J, Jackson, Anne U, Jonsson, Anna, Jørgensen, Marit E, Jørgensen, Torben, Kao, Wen-Hong L, Kerrison, Nicola D, Kinnunen, Leena, Klopp, Norman, Kong, Augustine, Kovacs, Peter, Kraft, Peter, Kravic, Jasmina, and Langford, Cordelia
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Biological Sciences ,Genetics ,Liver Disease ,Diabetes ,Human Genome ,Digestive Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Metabolic and endocrine ,Binding Sites ,Case-Control Studies ,Chromatin Immunoprecipitation ,Chromosome Mapping ,Diabetes Mellitus ,Type 2 ,Gene Expression Regulation ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genomics ,Hepatocyte Nuclear Factor 3-beta ,Humans ,Islets of Langerhans ,Liver ,Molecular Sequence Annotation ,Polymorphism ,Single Nucleotide ,Receptor ,Melatonin ,MT2 ,DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin immunoprecipitation binding sites in human islet and liver cells, including at MTNR1B, where fine mapping implicated rs10830963 as driving T2D association. We confirmed that the T2D risk allele for this SNP increases FOXA2-bound enhancer activity in islet- and liver-derived cells. We observed allele-specific differences in NEUROD1 binding in islet-derived cells, consistent with evidence that the T2D risk allele increases islet MTNR1B expression. Our study demonstrates how integration of genetic and genomic information can define molecular mechanisms through which variants underlying association signals exert their effects on disease.
- Published
- 2015
14. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
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Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., McCarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., and Lindgren, Cecilia M.
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- 2019
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15. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
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Speliotes, Elizabeth K, Willer, Cristen J, Berndt, Sonja I, Monda, Keri L, Thorleifsson, Gudmar, Jackson, Anne U, Allen, Hana Lango, Lindgren, Cecilia M, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C, Vedantam, Sailaja, Winkler, Thomas W, Qi, Lu, Workalemahu, Tsegaselassie, Heid, Iris M, Steinthorsdottir, Valgerdur, Stringham, Heather M, Weedon, Michael N, Wheeler, Eleanor, Wood, Andrew R, Ferreira, Teresa, Weyant, Robert J, Segrè, Ayellet V, Estrada, Karol, Liang, Liming, Nemesh, James, Park, Ju-Hyun, Gustafsson, Stefan, Kilpeläinen, Tuomas O, Yang, Jian, Bouatia-Naji, Nabila, Esko, Tõnu, Feitosa, Mary F, Kutalik, Zoltán, Mangino, Massimo, Raychaudhuri, Soumya, Scherag, Andre, Smith, Albert Vernon, Welch, Ryan, Zhao, Jing Hua, Aben, Katja K, Absher, Devin M, Amin, Najaf, Dixon, Anna L, Fisher, Eva, Glazer, Nicole L, Goddard, Michael E, Heard-Costa, Nancy L, Hoesel, Volker, Hottenga, Jouke-Jan, Johansson, Åsa, Johnson, Toby, Ketkar, Shamika, Lamina, Claudia, Li, Shengxu, Moffatt, Miriam F, Myers, Richard H, Narisu, Narisu, Perry, John RB, Peters, Marjolein J, Preuss, Michael, Ripatti, Samuli, Rivadeneira, Fernando, Sandholt, Camilla, Scott, Laura J, Timpson, Nicholas J, Tyrer, Jonathan P, van Wingerden, Sophie, Watanabe, Richard M, White, Charles C, Wiklund, Fredrik, Barlassina, Christina, Chasman, Daniel I, Cooper, Matthew N, Jansson, John-Olov, Lawrence, Robert W, Pellikka, Niina, Prokopenko, Inga, Shi, Jianxin, Thiering, Elisabeth, Alavere, Helene, Alibrandi, Maria TS, Almgren, Peter, Arnold, Alice M, Aspelund, Thor, Atwood, Larry D, Balkau, Beverley, Balmforth, Anthony J, Bennett, Amanda J, Ben-Shlomo, Yoav, Bergman, Richard N, Bergmann, Sven, Biebermann, Heike, Blakemore, Alexandra IF, Boes, Tanja, Bonnycastle, Lori L, Bornstein, Stefan R, Brown, Morris J, and Buchanan, Thomas A
- Subjects
Biological Sciences ,Genetics ,Prevention ,Human Genome ,Body Height ,Body Mass Index ,Body Size ,Body Weight ,Chromosome Mapping ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Obesity ,Polymorphism ,Single Nucleotide ,White People ,MAGIC ,Procardis Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
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- 2010
16. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
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Mahajan, Anubha, Taliun, Daniel, Thurner, Matthias, Robertson, Neil R., Torres, Jason M., Rayner, N. William, Payne, Anthony J., Steinthorsdottir, Valgerdur, Scott, Robert A., Grarup, Niels, Cook, James P., Schmidt, Ellen M., Wuttke, Matthias, Sarnowski, Chloé, Mägi, Reedik, Nano, Jana, Gieger, Christian, Trompet, Stella, Lecoeur, Cécile, Preuss, Michael H., Prins, Bram Peter, Guo, Xiuqing, Bielak, Lawrence F., Below, Jennifer E., Bowden, Donald W., Chambers, John Campbell, Kim, Young Jin, Ng, Maggie C. Y., Petty, Lauren E., Sim, Xueling, Zhang, Weihua, Bennett, Amanda J., Bork-Jensen, Jette, Brummett, Chad M., Canouil, Mickaël, Ec kardt, Kai-Uwe, Fischer, Krista, Kardia, Sharon L. R., Kronenberg, Florian, Läll, Kristi, Liu, Ching-Ti, Locke, Adam E., Luan, Jian’an, Ntalla, Ioanna, Nylander, Vibe, Schönherr, Sebastian, Schurmann, Claudia, Yengo, Loïc, Bottinger, Erwin P., Brandslund, Ivan, Christensen, Cramer, Dedoussis, George, Florez, Jose C., Ford, Ian, Franco, Oscar H., Frayling, Timothy M., Giedraitis, Vilmantas, Hackinger, Sophie, Hattersley, Andrew T., Herder, Christian, Ikram, M. Arfan, Ingelsson, Martin, Jørgensen, Marit E., Jørgensen, Torben, Kriebel, Jennifer, Kuusisto, Johanna, Ligthart, Symen, Lindgren, Cecilia M., Linneberg, Allan, Lyssenko, Valeriya, Mamakou, Vasiliki, Meitinger, Thomas, Mohlke, Karen L., Morris, Andrew D., Nadkarni, Girish, Pankow, James S., Peters, Annette, Sattar, Naveed, Stančáková, Alena, Strauch, Konstantin, Taylor, Kent D., Thorand, Barbara, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tuomilehto, Jaakko, Witte, Daniel R., Dupuis, Josée, Peyser, Patricia A., Zeggini, Eleftheria, Loos, Ruth J. F., Froguel, Philippe, Ingelsson, Erik, Lind, Lars, Groop, Leif, Laakso, Markku, Collins, Francis S., Jukema, J. Wouter, Palmer, Colin N. A., Grallert, Harald, Metspalu, Andres, Dehghan, Abbas, Köttgen, Anna, Abecasis, Goncalo R., Meigs, James B., Rotter, Jerome I., Marchini, Jonathan, Pedersen, Oluf, Hansen, Torben, Langenberg, Claudia, Wareham, Nicholas J., Stefansson, Kari, Gloyn, Anna L., Morris, Andrew P., Boehnke, Michael, and McCarthy, Mark I.
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- 2018
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17. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
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- 2018
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18. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Loohuis, Loes M. Olde, Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Edwards, Digna R. Velez, Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, Understanding Society Scientific Group, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., and Loos, Ruth J. F.
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- 2019
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19. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M., Schurmann, Claudia, Justice, Anne E., Fine, Rebecca S., Bradfield, Jonathan P., Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E., Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E., Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L., Alfred, Tamuno, Feitosa, Mary F., Masca, Nicholas G. D., Manning, Alisa K., Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie C. Y., Reiner, Alex P., Vedantam, Sailaja, Willems, Sara M., Winkler, Thomas W., Abecasis, Gonçalo, Aben, Katja K., Alam, Dewan S., Alharthi, Sameer E., Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W., Auer, Paul L., Balkau, Beverley, Bang, Lia E., Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bots, Michiel L., Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H., Broer, Linda, Brumat, Marco, Burt, Amber A., Butterworth, Adam S., Campbell, Peter T., Cappellani, Stefania, Carey, David J., Catamo, Eulalia, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Chen, Yii-Der I., Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Cocca, Massimiliano, Collins, Francis S., Cook, James P., Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J., Crosslin, David S., Cuellar-Partida, Gabriel, D’Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul I. W., Groot, Mark C. H., Mutsert, Renée, Deary, Ian J., Dedoussis, George, Demerath, Ellen W., Heijer, Martin, Hollander, Anneke I., Ruijter, Hester M., Dennis, Joe G., Denny, Josh C., Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Edwards, Todd L., Ellinghaus, David, Ellinor, Patrick T., Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D., Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Ford, Ian, Fornage, Myriam, Franco, Oscar H., Franke, Andre, Franks, Paul W., Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P., Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan F. A., Grarup, Niels, Griffiths, Helen L., Grove, Megan L., Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R., Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B., Hattersley, Andrew T., Have, Christian T., Hayward, Caroline, He, Liang, Heard-Costa, Nancy L., Heath, Andrew C., Heid, Iris M., Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W., Holmen, Oddgeir L., Hovingh, G. Kees, Howson, Joanna M. M., Hu, Yao, Huang, Paul L., Huffman, Jennifer E., Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jansson, Jan-Håkan, Jarvik, Gail P., Jensen, Gorm B., Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E., Jørgensen, Torben, Jukema, J. Wouter, Kahali, Bratati, Kahn, René S., Kähönen, Mika, Kamstrup, Pia R., Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A., Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Ethan M., Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Liu, Yongmei, Lo, Ken S., Lophatananon, Artitaya, Lotery, Andrew J., Loukola, Anu, Luan, Jian’an, Lubitz, Steven A., Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L., McCarthy, Mark I., McKean-Cowdin, Roberta, Medland, Sarah E., Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L., Moilanen, Leena, Moitry, Marie, Montgomery, Grant W., Mook-Kanamori, Dennis O., Moore, Carmel, Mori, Trevor A., Morris, Andrew D., Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Nalls, Mike A., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Nielsen, Sune F., Nikus, Kjell, Njølstad, Pål R., Nordestgaard, Børge G., Nyholt, Dale R., O’Connel, Jeffrey R., O’Donoghue, Michelle L., Olde Loohuis, Loes M., Ophoff, Roel A., Owen, Katharine R., Packard, Chris J., Padmanabhan, Sandosh, Palmer, Colin N. A., Palmer, Nicholette D., Pasterkamp, Gerard, Patel, Aniruddh P., Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L., Peloso, Gina M., Pennell, Craig E., Perola, Markus, Perry, James A., Perry, John R. B., Pers, Tune H., Person, Thomas N., Peters, Annette, Petersen, Eva R. B., Peyser, Patricia A., Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J., Puolijoki, Hannu, Raitakari, Olli T., Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F., Renström, Frida, Rheinberger, Myriam, Ridker, Paul M., Rioux, John D., Rivas, Manuel A., Roberts, David J., Robertson, Neil R., Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo P., Shah, Svati H., Sheu, Wayne H.-H., Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Albert V., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Starr, John M., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J., Tada, Hayato, Tansey, Katherine E., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P., Uher, Rudolf, Uitterlinden, André G., Uusitupa, Matti, Laan, Sander W., Duijn, Cornelia M., Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V., Varma, Rohit, Velez Edwards, Digna R., Vermeulen, Sita H., Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wang, Yiqin, Ware, Erin B., Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Witte, Daniel R., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I., Pospisilik, John A., Rivadeneira, Fernando, Borecki, Ingrid B., Deloukas, Panos, Frayling, Timothy M., Lettre, Guillaume, North, Kari E., Lindgren, Cecilia M., Hirschhorn, Joel N., Loos, Ruth J. F., CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, The MAGIC Investigators, and Understanding Society Scientific Group
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- 2018
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20. Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability
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Ivarsdottir, Erna V, primary, Steinthorsdottir, Valgerdur, additional, Daneshpour, Maryam S, additional, Thorleifsson, Gudmar, additional, Sulem, Patrick, additional, Holm, Hilma, additional, Sigurdsson, Snaevar, additional, Hreidarsson, Astradur B, additional, Sigurdsson, Gunnar, additional, Bjarnason, Ragnar, additional, Thorsson, Arni V, additional, Benediktsson, Rafn, additional, Eyjolfsson, Gudmundur, additional, Sigurdardottir, Olof, additional, Olafsson, Isleifur, additional, Zeinali, Sirous, additional, Azizi, Fereidoun, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F, additional, and Stefansson, Kari, additional
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- 2017
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21. Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease
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Helgadottir, Anna, primary, Gretarsdottir, Solveig, additional, Thorleifsson, Gudmar, additional, Hjartarson, Eirikur, additional, Sigurdsson, Asgeir, additional, Magnusdottir, Audur, additional, Jonasdottir, Aslaug, additional, Kristjansson, Helgi, additional, Sulem, Patrick, additional, Oddsson, Asmundur, additional, Sveinbjornsson, Gardar, additional, Steinthorsdottir, Valgerdur, additional, Rafnar, Thorunn, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Olafsson, Isleifur, additional, Eyjolfsson, Gudmundur I, additional, Sigurdardottir, Olof, additional, Daneshpour, Maryam S, additional, Khalili, Davood, additional, Azizi, Fereidoun, additional, Swinkels, Dorine W, additional, Kiemeney, Lambertus, additional, Quyyumi, Arshed A, additional, Levey, Allan I, additional, Patel, Riyaz S, additional, Hayek, Salim S, additional, Gudmundsdottir, Ingibjorg J, additional, Thorgeirsson, Gudmundur, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F, additional, Holm, Hilma, additional, and Stefansson, Kari, additional
- Published
- 2016
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22. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
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Steinthorsdottir, Valgerdur, primary, Thorleifsson, Gudmar, additional, Sulem, Patrick, additional, Helgason, Hannes, additional, Grarup, Niels, additional, Sigurdsson, Asgeir, additional, Helgadottir, Hafdis T, additional, Johannsdottir, Hrefna, additional, Magnusson, Olafur T, additional, Gudjonsson, Sigurjon A, additional, Justesen, Johanne M, additional, Harder, Marie N, additional, Jørgensen, Marit E, additional, Christensen, Cramer, additional, Brandslund, Ivan, additional, Sandbæk, Annelli, additional, Lauritzen, Torsten, additional, Vestergaard, Henrik, additional, Linneberg, Allan, additional, Jørgensen, Torben, additional, Hansen, Torben, additional, Daneshpour, Maryam S, additional, Fallah, Mohammad-Sadegh, additional, Hreidarsson, Astradur B, additional, Sigurdsson, Gunnar, additional, Azizi, Fereidoun, additional, Benediktsson, Rafn, additional, Masson, Gisli, additional, Helgason, Agnar, additional, Kong, Augustine, additional, Gudbjartsson, Daniel F, additional, Pedersen, Oluf, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
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- 2014
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23. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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Berndt, Sonja I, primary, Gustafsson, Stefan, additional, Mägi, Reedik, additional, Ganna, Andrea, additional, Wheeler, Eleanor, additional, Feitosa, Mary F, additional, Justice, Anne E, additional, Monda, Keri L, additional, Croteau-Chonka, Damien C, additional, Day, Felix R, additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U, additional, Luan, Jian'an, additional, Randall, Joshua C, additional, Vedantam, Sailaja, additional, Willer, Cristen J, additional, Winkler, Thomas W, additional, Wood, Andrew R, additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Lin, Dan-Yu, additional, Min, Josine L, additional, Neale, Benjamin M, additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L, additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E, additional, König, Inke R, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L, additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S, additional, Nolte, Ilja M, additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J, additional, Preuss, Michael, additional, Rose, Lynda M, additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J, additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D, additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vandenput, Liesbeth, additional, Waite, Lindsay L, additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W, additional, Atalay, Mustafa, additional, Attwood, Antony P, additional, Balmforth, Anthony J, additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L, additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I, additional, Chines, Peter S, additional, Collins, Francis S, additional, Connell, John M, additional, Cookson, William O, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M, additional, Farrall, Martin, additional, Ferrario, Marco M, additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V, additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S, additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Heath, Andrew C, additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B, additional, Hunt, Sarah E, additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B, additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimäki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T, additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H, additional, Lakka, Timo A, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A, additional, Magnusson, Patrik K, additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Mooser, Vincent, additional, Mühleisen, Thomas W, additional, Munroe, Patricia B, additional, Musk, Arthur W, additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A, additional, Ong, Ken K, additional, Oostra, Ben A, additional, Palmer, Colin N A, additional, Palotie, Aarno, additional, Peden, John F, additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P, additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E, additional, Sambrook, Jennifer G, additional, Sanders, Alan R, additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Stumvoll, Michael, additional, Swift, Amy J, additional, Theodoraki, Eirini V, additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M, additional, van Meurs, Joyce B J, additional, Vermeulen, Sita H, additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R, additional, Witteman, Jacqueline C M, additional, Wolffenbuttel, Bruce H R, additional, Wong, Andrew, additional, Wright, Alan F, additional, Zillikens, M Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Chanock, Stephen J, additional, Cupples, L Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Franks, Paul W, additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Hengstenberg, Christian, additional, Hicks, Andrew A, additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G, additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M, additional, Kiemeney, Lambertus A, additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F, additional, Martin, Nicholas G, additional, Metspalu, Andres, additional, Morris, Andrew D, additional, Nieminen, Markku S, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J, additional, Ouwehand, Willem H, additional, Palmer, Lyle J, additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M, additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Snieder, Harold, additional, Sørensen, Thorkild I A, additional, Spector, Timothy D, additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J, additional, Watkins, Hugh, additional, Wichmann, H-Erich, additional, Wilson, James F, additional, Abecasis, Goncalo R, additional, Assimes, Themistocles L, additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Fox, Caroline S, additional, Frayling, Timothy, additional, Groop, Leif C, additional, Haritunian, Talin, additional, Heid, Iris M, additional, Hunter, David, additional, Kaplan, Robert C, additional, Karpe, Fredrik, additional, Moffatt, Miriam F, additional, Mohlke, Karen L, additional, O'Connell, Jeffrey R, additional, Pawitan, Yudi, additional, Schadt, Eric E, additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Visscher, Peter M, additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I, additional, Speliotes, Elizabeth K, additional, North, Kari E, additional, Loos, Ruth J F, additional, and Ingelsson, Erik, additional
- Published
- 2013
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24. Variants in the fetal genome near FLT1 are associated with risk of preeclampsia
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McGinnis, Ralph, Steinthorsdottir, Valgerdur, Williams, Nicholas O, Thorleifsson, Gudmar, Shooter, Scott, Hjartardottir, Sigrun, Bumpstead, Suzannah, Stefansdottir, Lilja, Hildyard, Lucy, Sigurdsson, Jon K, Kemp, John P, Silva, Gabriela B, Thomsen, Liv Cecilie V, Jääskeläinen, Tiina, Kajantie, Eero, Chappell, Sally, Kalsheker, Noor, Moffett, Ashley, Hiby, Susan, Lee, Wai Kwong, Padmanabhan, Sandosh, Simpson, Nigel A B, Dolby, Vivien A, Staines-Urias, Eleonora, Engel, Stephanie M, Haugan, Anita, Trogstad, Lill, Svyatova, Gulnara, Zakhidova, Nodira, Najmutdinova, Dilbar, Dominiczak, Anna F, Gjessing, Håkon K, Casas, Juan P, Dudbridge, Frank, Walker, James J, Pipkin, Fiona Broughton, Thorsteinsdottir, Unnur, Geirsson, Reynir T, Lawlor, Debbie A, Iversen, Ann-Charlotte, Magnus, Per, Laivuori, Hannele, Stefansson, Kari, and Morgan, Linda
- Abstract
Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10−11) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.
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- 2017
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25. Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
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Heid, Iris M, primary, Jackson, Anne U, additional, Randall, Joshua C, additional, Winkler, Thomas W, additional, Qi, Lu, additional, Steinthorsdottir, Valgerdur, additional, Thorleifsson, Gudmar, additional, Zillikens, M Carola, additional, Speliotes, Elizabeth K, additional, Mägi, Reedik, additional, Workalemahu, Tsegaselassie, additional, White, Charles C, additional, Bouatia-Naji, Nabila, additional, Harris, Tamara B, additional, Berndt, Sonja I, additional, Ingelsson, Erik, additional, Willer, Cristen J, additional, Weedon, Michael N, additional, Luan, Jian'an, additional, Vedantam, Sailaja, additional, Esko, Tõnu, additional, Kilpeläinen, Tuomas O, additional, Kutalik, Zoltán, additional, Li, Shengxu, additional, Monda, Keri L, additional, Dixon, Anna L, additional, Holmes, Christopher C, additional, Kaplan, Lee M, additional, Liang, Liming, additional, Min, Josine L, additional, Moffatt, Miriam F, additional, Molony, Cliona, additional, Nicholson, George, additional, Schadt, Eric E, additional, Zondervan, Krina T, additional, Feitosa, Mary F, additional, Ferreira, Teresa, additional, Allen, Hana Lango, additional, Weyant, Robert J, additional, Wheeler, Eleanor, additional, Wood, Andrew R, additional, Estrada, Karol, additional, Goddard, Michael E, additional, Lettre, Guillaume, additional, Mangino, Massimo, additional, Nyholt, Dale R, additional, Purcell, Shaun, additional, Vernon Smith, Albert, additional, Visscher, Peter M, additional, Yang, Jian, additional, McCarroll, Steven A, additional, Nemesh, James, additional, Voight, Benjamin F, additional, Absher, Devin, additional, Amin, Najaf, additional, Aspelund, Thor, additional, Coin, Lachlan, additional, Glazer, Nicole L, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Hottenga, Jouke-Jan, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kaakinen, Marika, additional, Kapur, Karen, additional, Ketkar, Shamika, additional, Knowles, Joshua W, additional, Kraft, Peter, additional, Kraja, Aldi T, additional, Lamina, Claudia, additional, Leitzmann, Michael F, additional, McKnight, Barbara, additional, Morris, Andrew P, additional, Ong, Ken K, additional, Perry, John R B, additional, Peters, Marjolein J, additional, Polasek, Ozren, additional, Prokopenko, Inga, additional, Rayner, Nigel W, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Robertson, Neil R, additional, Sanna, Serena, additional, Sovio, Ulla, additional, Surakka, Ida, additional, Teumer, Alexander, additional, van Wingerden, Sophie, additional, Vitart, Veronique, additional, Zhao, Jing Hua, additional, Cavalcanti-Proença, Christine, additional, Chines, Peter S, additional, Fisher, Eva, additional, Kulzer, Jennifer R, additional, Lecoeur, Cecile, additional, Narisu, Narisu, additional, Sandholt, Camilla, additional, Scott, Laura J, additional, Silander, Kaisa, additional, Stark, Klaus, additional, Tammesoo, Mari-Liis, additional, Teslovich, Tanya M, additional, Timpson, Nicholas John, additional, Watanabe, Richard M, additional, Welch, Ryan, additional, Chasman, Daniel I, additional, Cooper, Matthew N, additional, Jansson, John-Olov, additional, Kettunen, Johannes, additional, Lawrence, Robert W, additional, Pellikka, Niina, additional, Perola, Markus, additional, Vandenput, Liesbeth, additional, Alavere, Helene, additional, Almgren, Peter, additional, Atwood, Larry D, additional, Bennett, Amanda J, additional, Biffar, Reiner, additional, Bonnycastle, Lori L, additional, Bornstein, Stefan R, additional, Buchanan, Thomas A, additional, Campbell, Harry, additional, Day, Ian N M, additional, Dei, Mariano, additional, Dörr, Marcus, additional, Elliott, Paul, additional, Erdos, Michael R, additional, Eriksson, Johan G, additional, Freimer, Nelson B, additional, Fu, Mao, additional, Gaget, Stefan, additional, Geus, Eco J C, additional, Gjesing, Anette P, additional, Grallert, Harald, additional, Gräßler, Jürgen, additional, Groves, Christopher J, additional, Guiducci, Candace, additional, Hartikainen, Anna-Liisa, additional, Hassanali, Neelam, additional, Havulinna, Aki S, additional, Herzig, Karl-Heinz, additional, Hicks, Andrew A, additional, Hui, Jennie, additional, Igl, Wilmar, additional, Jousilahti, Pekka, additional, Jula, Antti, additional, Kajantie, Eero, additional, Kinnunen, Leena, additional, Kolcic, Ivana, additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Kroemer, Heyo K, additional, Krzelj, Vjekoslav, additional, Kuusisto, Johanna, additional, Kvaloy, Kirsti, additional, Laitinen, Jaana, additional, Lantieri, Olivier, additional, Lathrop, G Mark, additional, Lokki, Marja-Liisa, additional, Luben, Robert N, additional, Ludwig, Barbara, additional, McArdle, Wendy L, additional, McCarthy, Anne, additional, Morken, Mario A, additional, Nelis, Mari, additional, Neville, Matt J, additional, Paré, Guillaume, additional, Parker, Alex N, additional, Peden, John F, additional, Pichler, Irene, additional, Pietiläinen, Kirsi H, additional, Platou, Carl G P, additional, Pouta, Anneli, additional, Ridderstråle, Martin, additional, Samani, Nilesh J, additional, Saramies, Jouko, additional, Sinisalo, Juha, additional, Smit, Jan H, additional, Strawbridge, Rona J, additional, Stringham, Heather M, additional, Swift, Amy J, additional, Teder-Laving, Maris, additional, Thomson, Brian, additional, Usala, Gianluca, additional, van Meurs, Joyce B J, additional, van Ommen, Gert-Jan, additional, Vatin, Vincent, additional, Volpato, Claudia B, additional, Wallaschofski, Henri, additional, Walters, G Bragi, additional, Widen, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Witte, Daniel R, additional, Zgaga, Lina, additional, Zitting, Paavo, additional, Beilby, John P, additional, James, Alan L, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Nieminen, Markku S, additional, Ohlsson, Claes, additional, Palmer, Lyle J, additional, Raitakari, Olli, additional, Ridker, Paul M, additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Viikari, Jorma, additional, Balkau, Beverley, additional, Ben-Shlomo, Yoav, additional, Bergman, Richard N, additional, Boeing, Heiner, additional, Smith, George Davey, additional, Ebrahim, Shah, additional, Froguel, Philippe, additional, Hansen, Torben, additional, Hengstenberg, Christian, additional, Hveem, Kristian, additional, Isomaa, Bo, additional, Jørgensen, Torben, additional, Karpe, Fredrik, additional, Khaw, Kay-Tee, additional, Laakso, Markku, additional, Lawlor, Debbie A, additional, Marre, Michel, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Midthjell, Kristian, additional, Pedersen, Oluf, additional, Salomaa, Veikko, additional, Schwarz, Peter E H, additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Valle, Timo T, additional, Wareham, Nicholas J, additional, Arnold, Alice M, additional, Beckmann, Jacques S, additional, Bergmann, Sven, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Collins, Francis S, additional, Eiriksdottir, Gudny, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Hattersley, Andrew T, additional, Hofman, Albert, additional, Hu, Frank B, additional, Illig, Thomas, additional, Iribarren, Carlos, additional, Jarvelin, Marjo-Riitta, additional, Kao, W H Linda, additional, Kaprio, Jaakko, additional, Launer, Lenore J, additional, Munroe, Patricia B, additional, Oostra, Ben, additional, Penninx, Brenda W, additional, Pramstaller, Peter P, additional, Psaty, Bruce M, additional, Quertermous, Thomas, additional, Rissanen, Aila, additional, Rudan, Igor, additional, Shuldiner, Alan R, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Syvanen, Ann-Christine, additional, Uda, Manuela, additional, Uitterlinden, André, additional, Völzke, Henry, additional, Vollenweider, Peter, additional, Wilson, James F, additional, Witteman, Jacqueline C, additional, Wright, Alan F, additional, Abecasis, Gonçalo R, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Frayling, Timothy M, additional, Groop, Leif C, additional, Haritunians, Talin, additional, Hunter, David J, additional, Kaplan, Robert C, additional, North, Kari E, additional, O'Connell, Jeffrey R, additional, Peltonen, Leena, additional, Schlessinger, David, additional, Strachan, David P, additional, Hirschhorn, Joel N, additional, Assimes, Themistocles L, additional, Wichmann, H-Erich, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Stefansson, Kari, additional, Cupples, L Adrienne, additional, Loos, Ruth J F, additional, Barroso, Inês, additional, McCarthy, Mark I, additional, Fox, Caroline S, additional, Mohlke, Karen L, additional, and Lindgren, Cecilia M, additional
- Published
- 2011
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26. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm
- Author
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Gretarsdottir, Solveig, primary, Baas, Annette F, additional, Thorleifsson, Gudmar, additional, Holm, Hilma, additional, den Heijer, Martin, additional, de Vries, Jean-Paul P M, additional, Kranendonk, Steef E, additional, Zeebregts, Clark J A M, additional, van Sterkenburg, Steven M, additional, Geelkerken, Robert H, additional, van Rij, Andre M, additional, Williams, Michael J A, additional, Boll, Albert P M, additional, Kostic, Jelena P, additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Walters, G Bragi, additional, Masson, Gisli, additional, Sulem, Patrick, additional, Saemundsdottir, Jona, additional, Mouy, Magali, additional, Magnusson, Kristinn P, additional, Tromp, Gerard, additional, Elmore, James R, additional, Sakalihasan, Natzi, additional, Limet, Raymond, additional, Defraigne, Jean-Olivier, additional, Ferrell, Robert E, additional, Ronkainen, Antti, additional, Ruigrok, Ynte M, additional, Wijmenga, Cisca, additional, Grobbee, Diederick E, additional, Shah, Svati H, additional, Granger, Christopher B, additional, Quyyumi, Arshed A, additional, Vaccarino, Viola, additional, Patel, Riyaz S, additional, Zafari, A Maziar, additional, Levey, Allan I, additional, Austin, Harland, additional, Girelli, Domenico, additional, Pignatti, Pier Franco, additional, Olivieri, Oliviero, additional, Martinelli, Nicola, additional, Malerba, Giovanni, additional, Trabetti, Elisabetta, additional, Becker, Lewis C, additional, Becker, Diane M, additional, Reilly, Muredach P, additional, Rader, Daniel J, additional, Mueller, Thomas, additional, Dieplinger, Benjamin, additional, Haltmayer, Meinhard, additional, Urbonavicius, Sigitas, additional, Lindblad, Bengt, additional, Gottsäter, Anders, additional, Gaetani, Eleonora, additional, Pola, Roberto, additional, Wells, Philip, additional, Rodger, Marc, additional, Forgie, Melissa, additional, Langlois, Nicole, additional, Corral, Javier, additional, Vicente, Vicente, additional, Fontcuberta, Jordi, additional, España, Francisco, additional, Grarup, Niels, additional, Jørgensen, Torben, additional, Witte, Daniel R, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Aben, Katja K, additional, de Graaf, Jacqueline, additional, Holewijn, Suzanne, additional, Folkersen, Lasse, additional, Franco-Cereceda, Anders, additional, Eriksson, Per, additional, Collier, David A, additional, Stefansson, Hreinn, additional, Steinthorsdottir, Valgerdur, additional, Rafnar, Thorunn, additional, Valdimarsson, Einar M, additional, Magnadottir, Hulda B, additional, Sveinbjornsdottir, Sigurlaug, additional, Olafsson, Isleifur, additional, Magnusson, Magnus Karl, additional, Palmason, Robert, additional, Haraldsdottir, Vilhelmina, additional, Andersen, Karl, additional, Onundarson, Pall T, additional, Thorgeirsson, Gudmundur, additional, Kiemeney, Lambertus A, additional, Powell, Janet T, additional, Carey, David J, additional, Kuivaniemi, Helena, additional, Lindholt, Jes S, additional, Jones, Gregory T, additional, Kong, Augustine, additional, Blankensteijn, Jan D, additional, Matthiasson, Stefan E, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2010
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27. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- Author
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Dupuis, Josée, primary, Langenberg, Claudia, additional, Prokopenko, Inga, additional, Saxena, Richa, additional, Soranzo, Nicole, additional, Jackson, Anne U, additional, Wheeler, Eleanor, additional, Glazer, Nicole L, additional, Bouatia-Naji, Nabila, additional, Gloyn, Anna L, additional, Lindgren, Cecilia M, additional, Mägi, Reedik, additional, Morris, Andrew P, additional, Randall, Joshua, additional, Johnson, Toby, additional, Elliott, Paul, additional, Rybin, Denis, additional, Thorleifsson, Gudmar, additional, Steinthorsdottir, Valgerdur, additional, Henneman, Peter, additional, Grallert, Harald, additional, Dehghan, Abbas, additional, Hottenga, Jouke Jan, additional, Franklin, Christopher S, additional, Navarro, Pau, additional, Song, Kijoung, additional, Goel, Anuj, additional, Perry, John R B, additional, Egan, Josephine M, additional, Lajunen, Taina, additional, Grarup, Niels, additional, Sparsø, Thomas, additional, Doney, Alex, additional, Voight, Benjamin F, additional, Stringham, Heather M, additional, Li, Man, additional, Kanoni, Stavroula, additional, Shrader, Peter, additional, Cavalcanti-Proença, Christine, additional, Kumari, Meena, additional, Qi, Lu, additional, Timpson, Nicholas J, additional, Gieger, Christian, additional, Zabena, Carina, additional, Rocheleau, Ghislain, additional, Ingelsson, Erik, additional, An, Ping, additional, O'Connell, Jeffrey, additional, Luan, Jian'an, additional, Elliott, Amanda, additional, McCarroll, Steven A, additional, Payne, Felicity, additional, Roccasecca, Rosa Maria, additional, Pattou, François, additional, Sethupathy, Praveen, additional, Ardlie, Kristin, additional, Ariyurek, Yavuz, additional, Balkau, Beverley, additional, Barter, Philip, additional, Beilby, John P, additional, Ben-Shlomo, Yoav, additional, Benediktsson, Rafn, additional, Bennett, Amanda J, additional, Bergmann, Sven, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Bonnefond, Amélie, additional, Bonnycastle, Lori L, additional, Borch-Johnsen, Knut, additional, Böttcher, Yvonne, additional, Brunner, Eric, additional, Bumpstead, Suzannah J, additional, Charpentier, Guillaume, additional, Chen, Yii-Der Ida, additional, Chines, Peter, additional, Clarke, Robert, additional, Coin, Lachlan J M, additional, Cooper, Matthew N, additional, Cornelis, Marilyn, additional, Crawford, Gabe, additional, Crisponi, Laura, additional, Day, Ian N M, additional, de Geus, Eco J C, additional, Delplanque, Jerome, additional, Dina, Christian, additional, Erdos, Michael R, additional, Fedson, Annette C, additional, Fischer-Rosinsky, Antje, additional, Forouhi, Nita G, additional, Fox, Caroline S, additional, Frants, Rune, additional, Franzosi, Maria Grazia, additional, Galan, Pilar, additional, Goodarzi, Mark O, additional, Graessler, Jürgen, additional, Groves, Christopher J, additional, Grundy, Scott, additional, Gwilliam, Rhian, additional, Gyllensten, Ulf, additional, Hadjadj, Samy, additional, Hallmans, Göran, additional, Hammond, Naomi, additional, Han, Xijing, additional, Hartikainen, Anna-Liisa, additional, Hassanali, Neelam, additional, Hayward, Caroline, additional, Heath, Simon C, additional, Hercberg, Serge, additional, Herder, Christian, additional, Hicks, Andrew A, additional, Hillman, David R, additional, Hingorani, Aroon D, additional, Hofman, Albert, additional, Hui, Jennie, additional, Hung, Joe, additional, Isomaa, Bo, additional, Johnson, Paul R V, additional, Jørgensen, Torben, additional, Jula, Antti, additional, Kaakinen, Marika, additional, Kaprio, Jaakko, additional, Kesaniemi, Y Antero, additional, Kivimaki, Mika, additional, Knight, Beatrice, additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Kyvik, Kirsten Ohm, additional, Lathrop, G Mark, additional, Lawlor, Debbie A, additional, Le Bacquer, Olivier, additional, Lecoeur, Cécile, additional, Li, Yun, additional, Lyssenko, Valeriya, additional, Mahley, Robert, additional, Mangino, Massimo, additional, Manning, Alisa K, additional, Martínez-Larrad, María Teresa, additional, McAteer, Jarred B, additional, McCulloch, Laura J, additional, McPherson, Ruth, additional, Meisinger, Christa, additional, Melzer, David, additional, Meyre, David, additional, Mitchell, Braxton D, additional, Morken, Mario A, additional, Mukherjee, Sutapa, additional, Naitza, Silvia, additional, Narisu, Narisu, additional, Neville, Matthew J, additional, Oostra, Ben A, additional, Orrù, Marco, additional, Pakyz, Ruth, additional, Palmer, Colin N A, additional, Paolisso, Giuseppe, additional, Pattaro, Cristian, additional, Pearson, Daniel, additional, Peden, John F, additional, Pedersen, Nancy L, additional, Perola, Markus, additional, Pfeiffer, Andreas F H, additional, Pichler, Irene, additional, Polasek, Ozren, additional, Posthuma, Danielle, additional, Potter, Simon C, additional, Pouta, Anneli, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Rathmann, Wolfgang, additional, Rayner, Nigel W, additional, Rice, Kenneth, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Roden, Michael, additional, Rolandsson, Olov, additional, Sandbaek, Annelli, additional, Sandhu, Manjinder, additional, Sanna, Serena, additional, Sayer, Avan Aihie, additional, Scheet, Paul, additional, Scott, Laura J, additional, Seedorf, Udo, additional, Sharp, Stephen J, additional, Shields, Beverley, additional, SigurÐsson, Gunnar, additional, Sijbrands, Eric J G, additional, Silveira, Angela, additional, Simpson, Laila, additional, Singleton, Andrew, additional, Smith, Nicholas L, additional, Sovio, Ulla, additional, Swift, Amy, additional, Syddall, Holly, additional, Syvänen, Ann-Christine, additional, Tanaka, Toshiko, additional, Thorand, Barbara, additional, Tichet, Jean, additional, Tönjes, Anke, additional, Tuomi, Tiinamaija, additional, Uitterlinden, André G, additional, van Dijk, Ko Willems, additional, van Hoek, Mandy, additional, Varma, Dhiraj, additional, Visvikis-Siest, Sophie, additional, Vitart, Veronique, additional, Vogelzangs, Nicole, additional, Waeber, Gérard, additional, Wagner, Peter J, additional, Walley, Andrew, additional, Walters, G Bragi, additional, Ward, Kim L, additional, Watkins, Hugh, additional, Weedon, Michael N, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Witteman, Jaqueline C M, additional, Yarnell, John W G, additional, Zeggini, Eleftheria, additional, Zelenika, Diana, additional, Zethelius, Björn, additional, Zhai, Guangju, additional, Zhao, Jing Hua, additional, Zillikens, M Carola, additional, Consortium, DIAGRAM, additional, Consortium, GIANT, additional, Consortium, Global BPgen, additional, Borecki, Ingrid B, additional, Loos, Ruth J F, additional, Meneton, Pierre, additional, Magnusson, Patrik K E, additional, Nathan, David M, additional, Williams, Gordon H, additional, Hattersley, Andrew T, additional, Silander, Kaisa, additional, Salomaa, Veikko, additional, Smith, George Davey, additional, Bornstein, Stefan R, additional, Schwarz, Peter, additional, Spranger, Joachim, additional, Karpe, Fredrik, additional, Shuldiner, Alan R, additional, Cooper, Cyrus, additional, Dedoussis, George V, additional, Serrano-Ríos, Manuel, additional, Morris, Andrew D, additional, Lind, Lars, additional, Palmer, Lyle J, additional, Hu, Frank B, additional, Franks, Paul W, additional, Ebrahim, Shah, additional, Marmot, Michael, additional, Kao, W H Linda, additional, Pankow, James S, additional, Sampson, Michael J, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Pramstaller, Peter Paul, additional, Wichmann, H Erich, additional, Illig, Thomas, additional, Rudan, Igor, additional, Wright, Alan F, additional, Stumvoll, Michael, additional, Campbell, Harry, additional, Wilson, James F, additional, Hamsten, Anders, additional, Bergman, Richard N, additional, Buchanan, Thomas A, additional, Collins, Francis S, additional, Mohlke, Karen L, additional, Tuomilehto, Jaakko, additional, Valle, Timo T, additional, Altshuler, David, additional, Rotter, Jerome I, additional, Siscovick, David S, additional, Penninx, Brenda W J H, additional, Boomsma, Dorret I, additional, Deloukas, Panos, additional, Spector, Timothy D, additional, Frayling, Timothy M, additional, Ferrucci, Luigi, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, van Duijn, Cornelia M, additional, Aulchenko, Yurii S, additional, Cao, Antonio, additional, Scuteri, Angelo, additional, Schlessinger, David, additional, Uda, Manuela, additional, Ruokonen, Aimo, additional, Jarvelin, Marjo-Riitta, additional, Waterworth, Dawn M, additional, Vollenweider, Peter, additional, Peltonen, Leena, additional, Mooser, Vincent, additional, Abecasis, Goncalo R, additional, Wareham, Nicholas J, additional, Sladek, Robert, additional, Froguel, Philippe, additional, Watanabe, Richard M, additional, Meigs, James B, additional, Groop, Leif, additional, Boehnke, Michael, additional, McCarthy, Mark I, additional, Florez, Jose C, additional, and Barroso, Inês, additional
- Published
- 2010
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28. New common variants affecting susceptibility to basal cell carcinoma
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Stacey, Simon N, primary, Sulem, Patrick, additional, Masson, Gisli, additional, Gudjonsson, Sigurjon A, additional, Thorleifsson, Gudmar, additional, Jakobsdottir, Margret, additional, Sigurdsson, Asgeir, additional, Gudbjartsson, Daniel F, additional, Sigurgeirsson, Bardur, additional, Benediktsdottir, Kristrun R, additional, Thorisdottir, Kristin, additional, Ragnarsson, Rafn, additional, Scherer, Dominique, additional, Hemminki, Kari, additional, Rudnai, Peter, additional, Gurzau, Eugene, additional, Koppova, Kvetoslava, additional, Botella-Estrada, Rafael, additional, Soriano, Virtudes, additional, Juberias, Pablo, additional, Saez, Berta, additional, Gilaberte, Yolanda, additional, Fuentelsaz, Victoria, additional, Corredera, Cristina, additional, Grasa, Matilde, additional, Höiom, Veronica, additional, Lindblom, Annika, additional, Bonenkamp, Johannes J, additional, van Rossum, Michelle M, additional, Aben, Katja K H, additional, de Vries, Esther, additional, Santinami, Mario, additional, Di Mauro, Maria G, additional, Maurichi, Andrea, additional, Wendt, Judith, additional, Hochleitner, Pia, additional, Pehamberger, Hubert, additional, Gudmundsson, Julius, additional, Magnusdottir, Droplaug N, additional, Gretarsdottir, Solveig, additional, Holm, Hilma, additional, Steinthorsdottir, Valgerdur, additional, Frigge, Michael L, additional, Blondal, Thorarinn, additional, Saemundsdottir, Jona, additional, Bjarnason, Hjördis, additional, Kristjansson, Kristleifur, additional, Bjornsdottir, Gyda, additional, Okamoto, Ichiro, additional, Rivoltini, Licia, additional, Rodolfo, Monica, additional, Kiemeney, Lambertus A, additional, Hansson, Johan, additional, Nagore, Eduardo, additional, Mayordomo, José I, additional, Kumar, Rajiv, additional, Karagas, Margaret R, additional, Nelson, Heather H, additional, Gulcher, Jeffrey R, additional, Rafnar, Thorunn, additional, Thorsteinsdottir, Unnur, additional, Olafsson, Jon H, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2009
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29. Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche
- Author
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Sulem, Patrick, primary, Gudbjartsson, Daniel F, additional, Rafnar, Thorunn, additional, Holm, Hilma, additional, Olafsdottir, Elinborg J, additional, Olafsdottir, Gudridur H, additional, Jonsson, Thorvaldur, additional, Alexandersen, Peter, additional, Feenstra, Bjarke, additional, Boyd, Heather A, additional, Aben, Katja K, additional, Verbeek, Andre L M, additional, Roeleveld, Nel, additional, Jonasdottir, Aslaug, additional, Styrkarsdottir, Unnur, additional, Steinthorsdottir, Valgerdur, additional, Karason, Ari, additional, Stacey, Simon N, additional, Gudmundsson, Julius, additional, Jakobsdottir, Margret, additional, Thorleifsson, Gudmar, additional, Hardarson, Gudmundur, additional, Gulcher, Jeffrey, additional, Kong, Augustine, additional, Kiemeney, Lambertus A, additional, Melbye, Mads, additional, Christiansen, Claus, additional, Tryggvadottir, Laufey, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2009
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30. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
- Author
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Gudbjartsson, Daniel F, primary, Bjornsdottir, Unnur S, additional, Halapi, Eva, additional, Helgadottir, Anna, additional, Sulem, Patrick, additional, Jonsdottir, Gudrun M, additional, Thorleifsson, Gudmar, additional, Helgadottir, Hafdis, additional, Steinthorsdottir, Valgerdur, additional, Stefansson, Hreinn, additional, Williams, Carolyn, additional, Hui, Jennie, additional, Beilby, John, additional, Warrington, Nicole M, additional, James, Alan, additional, Palmer, Lyle J, additional, Koppelman, Gerard H, additional, Heinzmann, Andrea, additional, Krueger, Marcus, additional, Boezen, H Marike, additional, Wheatley, Amanda, additional, Altmuller, Janine, additional, Shin, Hyoung Doo, additional, Uh, Soo-Taek, additional, Cheong, Hyun Sub, additional, Jonsdottir, Brynja, additional, Gislason, David, additional, Park, Choon-Sik, additional, Rasmussen, Linda M, additional, Porsbjerg, Celeste, additional, Hansen, Jakob W, additional, Backer, Vibeke, additional, Werge, Thomas, additional, Janson, Christer, additional, Jönsson, Ulla-Britt, additional, Ng, Maggie C Y, additional, Chan, Juliana, additional, So, Wing Yee, additional, Ma, Ronald, additional, Shah, Svati H, additional, Granger, Christopher B, additional, Quyyumi, Arshed A, additional, Levey, Allan I, additional, Vaccarino, Viola, additional, Reilly, Muredach P, additional, Rader, Daniel J, additional, Williams, Michael J A, additional, van Rij, Andre M, additional, Jones, Gregory T, additional, Trabetti, Elisabetta, additional, Malerba, Giovanni, additional, Pignatti, Pier Franco, additional, Boner, Attilio, additional, Pescollderungg, Lydia, additional, Girelli, Domenico, additional, Olivieri, Oliviero, additional, Martinelli, Nicola, additional, Ludviksson, Bjorn R, additional, Ludviksdottir, Dora, additional, Eyjolfsson, Gudmundur I, additional, Arnar, David, additional, Thorgeirsson, Gudmundur, additional, Deichmann, Klaus, additional, Thompson, Philip J, additional, Wjst, Matthias, additional, Hall, Ian P, additional, Postma, Dirkje S, additional, Gislason, Thorarinn, additional, Gulcher, Jeffrey, additional, Kong, Augustine, additional, Jonsdottir, Ingileif, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2009
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31. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
- Author
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Thorleifsson, Gudmar, primary, Walters, G Bragi, additional, Gudbjartsson, Daniel F, additional, Steinthorsdottir, Valgerdur, additional, Sulem, Patrick, additional, Helgadottir, Anna, additional, Styrkarsdottir, Unnur, additional, Gretarsdottir, Solveig, additional, Thorlacius, Steinunn, additional, Jonsdottir, Ingileif, additional, Jonsdottir, Thorbjorg, additional, Olafsdottir, Elinborg J, additional, Olafsdottir, Gudridur H, additional, Jonsson, Thorvaldur, additional, Jonsson, Frosti, additional, Borch-Johnsen, Knut, additional, Hansen, Torben, additional, Andersen, Gitte, additional, Jorgensen, Torben, additional, Lauritzen, Torsten, additional, Aben, Katja K, additional, Verbeek, André LM, additional, Roeleveld, Nel, additional, Kampman, Ellen, additional, Yanek, Lisa R, additional, Becker, Lewis C, additional, Tryggvadottir, Laufey, additional, Rafnar, Thorunn, additional, Becker, Diane M, additional, Gulcher, Jeffrey, additional, Kiemeney, Lambertus A, additional, Pedersen, Oluf, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2008
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32. Variants in MTNR1B influence fasting glucose levels
- Author
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Prokopenko, Inga, primary, Langenberg, Claudia, additional, Florez, Jose C, additional, Saxena, Richa, additional, Soranzo, Nicole, additional, Thorleifsson, Gudmar, additional, Loos, Ruth J F, additional, Manning, Alisa K, additional, Jackson, Anne U, additional, Aulchenko, Yurii, additional, Potter, Simon C, additional, Erdos, Michael R, additional, Sanna, Serena, additional, Hottenga, Jouke-Jan, additional, Wheeler, Eleanor, additional, Kaakinen, Marika, additional, Lyssenko, Valeriya, additional, Chen, Wei-Min, additional, Ahmadi, Kourosh, additional, Beckmann, Jacques S, additional, Bergman, Richard N, additional, Bochud, Murielle, additional, Bonnycastle, Lori L, additional, Buchanan, Thomas A, additional, Cao, Antonio, additional, Cervino, Alessandra, additional, Coin, Lachlan, additional, Collins, Francis S, additional, Crisponi, Laura, additional, de Geus, Eco J C, additional, Dehghan, Abbas, additional, Deloukas, Panos, additional, Doney, Alex S F, additional, Elliott, Paul, additional, Freimer, Nelson, additional, Gateva, Vesela, additional, Herder, Christian, additional, Hofman, Albert, additional, Hughes, Thomas E, additional, Hunt, Sarah, additional, Illig, Thomas, additional, Inouye, Michael, additional, Isomaa, Bo, additional, Johnson, Toby, additional, Kong, Augustine, additional, Krestyaninova, Maria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lim, Noha, additional, Lindblad, Ulf, additional, Lindgren, Cecilia M, additional, McCann, Owen T, additional, Mohlke, Karen L, additional, Morris, Andrew D, additional, Naitza, Silvia, additional, Orrù, Marco, additional, Palmer, Colin N A, additional, Pouta, Anneli, additional, Randall, Joshua, additional, Rathmann, Wolfgang, additional, Saramies, Jouko, additional, Scheet, Paul, additional, Scott, Laura J, additional, Scuteri, Angelo, additional, Sharp, Stephen, additional, Sijbrands, Eric, additional, Smit, Jan H, additional, Song, Kijoung, additional, Steinthorsdottir, Valgerdur, additional, Stringham, Heather M, additional, Tuomi, Tiinamaija, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Voight, Benjamin F, additional, Waterworth, Dawn, additional, Wichmann, H-Erich, additional, Willemsen, Gonneke, additional, Witteman, Jacqueline C M, additional, Yuan, Xin, additional, Zhao, Jing Hua, additional, Zeggini, Eleftheria, additional, Schlessinger, David, additional, Sandhu, Manjinder, additional, Boomsma, Dorret I, additional, Uda, Manuela, additional, Spector, Tim D, additional, Penninx, Brenda WJH, additional, Altshuler, David, additional, Vollenweider, Peter, additional, Jarvelin, Marjo Riitta, additional, Lakatta, Edward, additional, Waeber, Gerard, additional, Fox, Caroline S, additional, Peltonen, Leena, additional, Groop, Leif C, additional, Mooser, Vincent, additional, Cupples, L Adrienne, additional, Thorsteinsdottir, Unnur, additional, Boehnke, Michael, additional, Barroso, Inês, additional, Van Duijn, Cornelia, additional, Dupuis, Josée, additional, Watanabe, Richard M, additional, Stefansson, Kari, additional, McCarthy, Mark I, additional, Wareham, Nicholas J, additional, Meigs, James B, additional, and Abecasis, Gonçalo R, additional
- Published
- 2008
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33. Many sequence variants affecting diversity of adult human height
- Author
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Gudbjartsson, Daniel F, primary, Walters, G Bragi, additional, Thorleifsson, Gudmar, additional, Stefansson, Hreinn, additional, Halldorsson, Bjarni V, additional, Zusmanovich, Pasha, additional, Sulem, Patrick, additional, Thorlacius, Steinunn, additional, Gylfason, Arnaldur, additional, Steinberg, Stacy, additional, Helgadottir, Anna, additional, Ingason, Andres, additional, Steinthorsdottir, Valgerdur, additional, Olafsdottir, Elinborg J, additional, Olafsdottir, Gudridur H, additional, Jonsson, Thorvaldur, additional, Borch-Johnsen, Knut, additional, Hansen, Torben, additional, Andersen, Gitte, additional, Jorgensen, Torben, additional, Pedersen, Oluf, additional, Aben, Katja K, additional, Witjes, J Alfred, additional, Swinkels, Dorine W, additional, Heijer, Martin den, additional, Franke, Barbara, additional, Verbeek, Andre L M, additional, Becker, Diane M, additional, Yanek, Lisa R, additional, Becker, Lewis C, additional, Tryggvadottir, Laufey, additional, Rafnar, Thorunn, additional, Gulcher, Jeffrey, additional, Kiemeney, Lambertus A, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2008
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34. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
- Author
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Helgadottir, Anna, primary, Thorleifsson, Gudmar, additional, Magnusson, Kristinn P, additional, Grétarsdottir, Solveig, additional, Steinthorsdottir, Valgerdur, additional, Manolescu, Andrei, additional, Jones, Gregory T, additional, Rinkel, Gabriel J E, additional, Blankensteijn, Jan D, additional, Ronkainen, Antti, additional, Jääskeläinen, Juha E, additional, Kyo, Yoshiki, additional, Lenk, Guy M, additional, Sakalihasan, Natzi, additional, Kostulas, Konstantinos, additional, Gottsäter, Anders, additional, Flex, Andrea, additional, Stefansson, Hreinn, additional, Hansen, Torben, additional, Andersen, Gitte, additional, Weinsheimer, Shantel, additional, Borch-Johnsen, Knut, additional, Jorgensen, Torben, additional, Shah, Svati H, additional, Quyyumi, Arshed A, additional, Granger, Christopher B, additional, Reilly, Muredach P, additional, Austin, Harland, additional, Levey, Allan I, additional, Vaccarino, Viola, additional, Palsdottir, Ebba, additional, Walters, G Bragi, additional, Jonsdottir, Thorbjorg, additional, Snorradottir, Steinunn, additional, Magnusdottir, Dana, additional, Gudmundsson, Gudmundur, additional, Ferrell, Robert E, additional, Sveinbjornsdottir, Sigurlaug, additional, Hernesniemi, Juha, additional, Niemelä, Mika, additional, Limet, Raymond, additional, Andersen, Karl, additional, Sigurdsson, Gunnar, additional, Benediktsson, Rafn, additional, Verhoeven, Eric L G, additional, Teijink, Joep A W, additional, Grobbee, Diederick E, additional, Rader, Daniel J, additional, Collier, David A, additional, Pedersen, Oluf, additional, Pola, Roberto, additional, Hillert, Jan, additional, Lindblad, Bengt, additional, Valdimarsson, Einar M, additional, Magnadottir, Hulda B, additional, Wijmenga, Cisca, additional, Tromp, Gerard, additional, Baas, Annette F, additional, Ruigrok, Ynte M, additional, van Rij, Andre M, additional, Kuivaniemi, Helena, additional, Powell, Janet T, additional, Matthiasson, Stefan E, additional, Gulcher, Jeffrey R, additional, Thorgeirsson, Gudmundur, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2008
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35. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
- Author
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Gudmundsson, Julius, primary, Sulem, Patrick, additional, Steinthorsdottir, Valgerdur, additional, Bergthorsson, Jon T, additional, Thorleifsson, Gudmar, additional, Manolescu, Andrei, additional, Rafnar, Thorunn, additional, Gudbjartsson, Daniel, additional, Agnarsson, Bjarni A, additional, Baker, Adam, additional, Sigurdsson, Asgeir, additional, Benediktsdottir, Kristrun R, additional, Jakobsdottir, Margret, additional, Blondal, Thorarinn, additional, Stacey, Simon N, additional, Helgason, Agnar, additional, Gunnarsdottir, Steinunn, additional, Olafsdottir, Adalheidur, additional, Kristinsson, Kari T, additional, Birgisdottir, Birgitta, additional, Ghosh, Shyamali, additional, Thorlacius, Steinunn, additional, Magnusdottir, Dana, additional, Stefansdottir, Gerdur, additional, Kristjansson, Kristleifur, additional, Bagger, Yu, additional, Wilensky, Robert L, additional, Reilly, Muredach P, additional, Morris, Andrew D, additional, Kimber, Charlotte H, additional, Adeyemo, Adebowale, additional, Chen, Yuanxiu, additional, Zhou, Jie, additional, So, Wing-Yee, additional, Tong, Peter C Y, additional, Ng, Maggie C Y, additional, Hansen, Torben, additional, Andersen, Gitte, additional, Borch-Johnsen, Knut, additional, Jorgensen, Torben, additional, Tres, Alejandro, additional, Fuertes, Fernando, additional, Ruiz-Echarri, Manuel, additional, Asin, Laura, additional, Saez, Berta, additional, van Boven, Erica, additional, Klaver, Siem, additional, Swinkels, Dorine W, additional, Aben, Katja K, additional, Graif, Theresa, additional, Cashy, John, additional, Suarez, Brian K, additional, van Vierssen Trip, Onco, additional, Frigge, Michael L, additional, Ober, Carole, additional, Hofker, Marten H, additional, Wijmenga, Cisca, additional, Christiansen, Claus, additional, Rader, Daniel J, additional, Palmer, Colin N A, additional, Rotimi, Charles, additional, Chan, Juliana C N, additional, Pedersen, Oluf, additional, Sigurdsson, Gunnar, additional, Benediktsson, Rafn, additional, Jonsson, Eirikur, additional, Einarsson, Gudmundur V, additional, Mayordomo, Jose I, additional, Catalona, William J, additional, Kiemeney, Lambertus A, additional, Barkardottir, Rosa B, additional, Gulcher, Jeffrey R, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2007
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36. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
- Author
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Steinthorsdottir, Valgerdur, primary, Thorleifsson, Gudmar, additional, Reynisdottir, Inga, additional, Benediktsson, Rafn, additional, Jonsdottir, Thorbjorg, additional, Walters, G Bragi, additional, Styrkarsdottir, Unnur, additional, Gretarsdottir, Solveig, additional, Emilsson, Valur, additional, Ghosh, Shyamali, additional, Baker, Adam, additional, Snorradottir, Steinunn, additional, Bjarnason, Hjordis, additional, Ng, Maggie C Y, additional, Hansen, Torben, additional, Bagger, Yu, additional, Wilensky, Robert L, additional, Reilly, Muredach P, additional, Adeyemo, Adebowale, additional, Chen, Yuanxiu, additional, Zhou, Jie, additional, Gudnason, Vilmundur, additional, Chen, Guanjie, additional, Huang, Hanxia, additional, Lashley, Kerrie, additional, Doumatey, Ayo, additional, So, Wing-Yee, additional, Ma, Ronald C Y, additional, Andersen, Gitte, additional, Borch-Johnsen, Knut, additional, Jorgensen, Torben, additional, van Vliet-Ostaptchouk, Jana V, additional, Hofker, Marten H, additional, Wijmenga, Cisca, additional, Christiansen, Claus, additional, Rader, Daniel J, additional, Rotimi, Charles, additional, Gurney, Mark, additional, Chan, Juliana C N, additional, Pedersen, Oluf, additional, Sigurdsson, Gunnar, additional, Gulcher, Jeffrey R, additional, Thorsteinsdottir, Unnur, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2007
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37. A common inversion under selection in Europeans
- Author
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Stefansson, Hreinn, primary, Helgason, Agnar, additional, Thorleifsson, Gudmar, additional, Steinthorsdottir, Valgerdur, additional, Masson, Gisli, additional, Barnard, John, additional, Baker, Adam, additional, Jonasdottir, Aslaug, additional, Ingason, Andres, additional, Gudnadottir, Vala G, additional, Desnica, Natasa, additional, Hicks, Andrew, additional, Gylfason, Arnaldur, additional, Gudbjartsson, Daniel F, additional, Jonsdottir, Gudrun M, additional, Sainz, Jesus, additional, Agnarsson, Kari, additional, Birgisdottir, Birgitta, additional, Ghosh, Shyamali, additional, Olafsdottir, Adalheidur, additional, Cazier, Jean-Baptiste, additional, Kristjansson, Kristleifur, additional, Frigge, Michael L, additional, Thorgeirsson, Thorgeir E, additional, Gulcher, Jeffrey R, additional, Kong, Augustine, additional, and Stefansson, Kari, additional
- Published
- 2005
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38. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
- Author
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Morris, Andrew P, Voight, Benjamin F, Teslovich, Tanya M, Ferreira, Teresa, Segrè, Ayellet V, Steinthorsdottir, Valgerdur, Strawbridge, Rona J, Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M, Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, and Luan, Jian'an
- Subjects
PATHOLOGICAL physiology ,TYPE 2 diabetes ,MOLECULAR genetics ,GENOMES ,DATA analysis ,BIOLOGICAL variation ,CELL cycle regulation - Abstract
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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39. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
- Author
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Heid, Iris M., Jackson, Anne U., Randall, Joshua C., Winkler, Thomas W., Lu Qi, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M. Carola, Speliotes, Elizabeth K., Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C., Bouatia-Naji, Nabila, Harris, Tamara B., Berndt, Sonja I., Ingelsson, Erik, Willer, Cristen J., Weedon, Michael N., Luan, Jian'an, and Vedantam, Sailaja
- Subjects
WAIST-hip ratio ,META-analysis ,LOCUS (Genetics) ,SEXUAL dimorphism in animals ,ADIPOSE tissues - Abstract
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10
−9 to P = 1.8 × 10−40 ) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13 ). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
- View/download PDF
40. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
- Author
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Voight, Benjamin F, Scott, Laura J, Steinthorsdottir, Valgerdur, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, Thorleifsson, Gudmar, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J, Raychaudhuri, Soumya, McCarroll, Steve A, Langenberg, Claudia, and Hofmann, Oliver M
- Subjects
GENETICS of type 2 diabetes ,GENOMES ,DISEASE susceptibility ,LOCUS (Genetics) ,META-analysis ,X chromosome ,MECHANISM of action for insulin ,CELL cycle regulation - Abstract
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 × 10
−8 . These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits. [ABSTRACT FROM AUTHOR]- Published
- 2010
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41. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
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Dupuis, Josée, Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Soranzo, Nicole, Jackson, Anne U., Wheeler, Eleanor, Glazer, Nicole L., Bouatia-Naji, Nabila, Gloyn, Anna L., Lindgren, Cecilia M., Mägi, Reedik, Morris, Andrew P., Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Thorleifsson, Gudmar, Steinthorsdottir, Valgerdur, and Henneman, Peter
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TYPE 2 diabetes ,GLUCOSE ,PANCREATIC beta cells ,INSULIN ,CELL proliferation ,GENOMICS ,DIABETES - Abstract
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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42. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
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Thorleifsson, Gudmar, Walters, G. Bragi, Gudbjartsson, Daniel F., Steinthorsdottir, Valgerdur, Sulem, Patrick, Helgadottir, Anna, Styrkarsdottir, Unnur, Gretarsdottir, Solveig, Thorlacius, Steinunn, Jonsdottir, Ingileif, Jonsdottir, Thorbjorg, Olafsdottir, Elinborg J., Olafsdottir, Gudridur H., Jonsson, Thorvaldur, Jonsson, Frosti, Borch-Johnsen, Knut, Hansen, Torben, Andersen, Gitte, Jorgensen, Torben, and Lauritzen, Torsten
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OBESITY risk factors ,GENOMES ,GENES ,BODY mass index ,CHROMOSOME inversions ,BODY weight - Abstract
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 × 10
−7 . This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity. [ABSTRACT FROM AUTHOR]- Published
- 2009
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43. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
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Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, de Bakker, Paul IW, Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Angelantonio, Emanuele Di, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O'Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CH, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Internal Medicine, Epidemiology, Obstetrics & Gynecology, Radiology & Nuclear Medicine, CHD Exome+ Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Institute for Molecular Medicine Finland, Research Programs Unit, Diabetes and Obesity Research Program, University of Helsinki, Young, Kristin L [0000-0003-0070-6145], Mahajan, Anubha [0000-0001-5585-3420], Winkler, Thomas W [0000-0003-0292-5421], Locke, Adam E [0000-0001-6227-198X], Medina-Gomez, Carolina [0000-0001-7999-5538], Giri, Ayush [0000-0002-7786-4670], Ng, Maggie CY [0000-0002-4133-2007], Heard-Costa, Nancy L [0000-0001-9730-0306], Manning, Alisa K [0000-0003-0247-902X], Alam, Dewan S [0000-0002-2051-3837], Amouyel, Philippe [0000-0001-9088-234X], Bergmann, Sven [0000-0002-6785-9034], Boehnke, Michael [0000-0002-6442-7754], Butterworth, Adam S [0000-0002-6915-9015], Caulfield, Mark J [0000-0001-9295-3594], Collins, Francis S [0000-0002-1023-7410], de Bakker, Paul IW [0000-0001-7735-7858], Dennis, Joe G [0000-0003-4591-1214], Easton, Douglas F [0000-0003-2444-3247], Elliott, Paul [0000-0002-7511-5684], Evangelou, Evangelos [0000-0002-5488-2999], Giedraitis, Vilmantas [0000-0003-3423-2021], Girotto, Giorgia [0000-0003-4507-6589], Grarup, Niels [0000-0001-5526-1070], Gustafsson, Stefan [0000-0001-5894-0351], Hansen, Torben [0000-0001-8748-3831], Hayward, Caroline [0000-0002-9405-9550], Howson, Joanna MM [0000-0001-7618-0050], Ikram, M Arfan [0000-0003-0372-8585], Jackson, Anne U [0000-0002-9672-2547], Justesen, Johanne M [0000-0002-0484-8522], Kovacs, Peter [0000-0002-0290-5423], Kuulasmaa, Kari [0000-0003-2165-1411], Langenberg, Claudia [0000-0002-5017-7344], Lin, Li-An [0000-0003-2731-1346], Linneberg, Allan [0000-0002-0994-0184], Liu, Ching-Ti [0000-0002-0703-0742], Lyytikäinen, Leo-Pekka [0000-0002-7200-5455], MacGregor, Stuart [0000-0001-6731-8142], McCarthy, Mark I [0000-0002-4393-0510], Morgan, Anna [0000-0001-6290-445X], Müller-Nurasyid, Martina [0000-0003-3793-5910], Munroe, Patricia B [0000-0002-4176-2947], Narisu, Narisu [0000-0002-8483-1156], Neville, Matt [0000-0002-6004-5433], Reilly, Dermot F [0000-0002-9456-1364], Rudan, Igor [0000-0001-6993-6884], Saleheen, Danish [0000-0001-6193-020X], Salomaa, Veikko [0000-0001-7563-5324], Sim, Xueling [0000-0002-1233-7642], Small, Kerrin S [0000-0003-4566-0005], Smith, Blair H [0000-0002-5362-9430], Smith, Jennifer A [0000-0002-3575-5468], Southam, Lorraine [0000-0002-7546-9650], Stefansson, Kari [0000-0003-1676-864X], Stirrups, Kathleen E [0000-0002-6823-3252], Stringham, Heather M [0000-0002-2991-6392], Teumer, Alexander [0000-0002-8309-094X], Thompson, Deborah J [0000-0003-1465-5799], Vestergaard, Henrik [0000-0003-3090-269X], Vitart, Veronique [0000-0002-4991-3797], Wang, Carol A [0000-0002-4301-3974], Wessel, Jennifer [0000-0002-7031-0085], Willer, Cristen J [0000-0001-5645-4966], Zeggini, Eleftheria [0000-0003-4238-659X], Rivadeneira, Fernando [0000-0001-9435-9441], Pospisilik, J Andrew [0000-0002-9745-0977], Deloukas, Panos [0000-0001-9251-070X], Mohlke, Karen L [0000-0001-6721-153X], Kutalik, Zoltán [0000-0001-8285-7523], Loos, Ruth JF [0000-0002-8532-5087], Lindgren, Cecilia M [0000-0002-4903-9374], Apollo - University of Cambridge Repository, Home Office, Medical Research Council (MRC), National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, UK DRI Ltd, Medical and Clinical Psychology, Justice, Anne E., Karaderi, Tugce, Highland, Heather M., Young, Kristin L., Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L., Fine, Rebecca S., Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W., Locke, Adam E., Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie C. Y., Heard-Costa, Nancy L., Feitosa, Mary F., Manning, Alisa K., Willems, Sara M., Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S., Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F., Blüher, Matthia, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A., Bork-Jensen, Jette, Bottinger, Erwin P., Bowden, Donald W., Brandslund, Ivan, Broer, Linda, Burt, Amber A., Butterworth, Adam S., Caulfield, Mark J., Cesana, Giancarlo, Chambers, John C., Chasman, Daniel I., Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y., Collins, Francis S., Cook, James P., Cox, Amanda J., Crosslin, David S., Danesh, John, de Bakker, Paul I. W., Denus, Simon de, Mutsert, Renée de, Dedoussis, George, Demerath, Ellen W., Dennis, Joe G., Denny, Josh C., Angelantonio, Emanuele Di, Dörr, Marcu, Drenos, Fotio, Dubé, Marie-Pierre, Dunning, Alison M., Easton, Douglas F., Elliott, Paul, Evangelou, Evangelo, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C., Fornage, Myriam, Fox, Caroline S., Franks, Paul W., Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmanta, Girotto, Giorgia, Gorski, Mathia, Grallert, Harald, Grarup, Niel, Grove, Megan L., Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T., Hayward, Caroline, Heid, Iris M., Holmen, Oddgeir L., Hovingh, G. Kee, Howson, Joanna M. M., Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M. Arfan, Ingelsson, Erik, Jackson, Anne U., Jarvik, Gail P., Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M., Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon L. R., Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S., Kovacs, Peter, Krämer, Bernhard K., Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A., Lamparter, David, Lange, Leslie A., Langenberg, Claudia, Larson, Eric B., Lee, Nanette R., Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E., Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lar, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J., Luan, Jian’An, Lyytikäinen, Leo-Pekka, Macgregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas G. D., Mccarthy, Mark I., Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O., Morgan, Anna, Morris, Andrew P., Müller-Nurasyid, Martina, Munroe, Patricia B., Narisu, Narisu, Nelson, Christopher P., Neville, Matt, Ntalla, Ioanna, O’Connell, Jeffrey R., Owen, Katharine R., Pedersen, Oluf, Peloso, Gina M., Pennell, Craig E., Perola, Marku, Perry, James A., Perry, John R. B., Pers, Tune H., Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T., Rasheed, Asif, Raulerson, Chelsea K., Rauramaa, Rainer, Reilly, Dermot F., Reiner, Alex P., Ridker, Paul M., Rivas, Manuel A., Robertson, Neil R., Robino, Antonietta, Rudan, Igor, Ruth, Katherine S., Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J., Schreiner, Pamela J., Schulze, Matthias B., Scott, Robert A., Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J., Small, Kerrin S., Smith, Blair H., Smith, Jennifer A., Southam, Lorraine, Spector, Timothy D., Speliotes, Elizabeth K., Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin M. A., Tardif, Jean-Claude, Taylor, Kent D., Teumer, Alexander, Thompson, Deborah J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H., Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van Duijn, Cornelia M., Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H., Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F., Vuckovic, Dragana, Wagenknecht, Lynne E., Walker, Mark, Wallentin, Lar, Wang, Feijie, Wang, Carol A., Wang, Shuai, Wareham, Nicholas J., Warren, Helen R., Waterworth, Dawn M., Wessel, Jennifer, White, Harvey D., Willer, Cristen J., Wilson, James G., Wood, Andrew R., Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M., Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M. Carola, Rivadeneira, Fernando, Borecki, Ingrid B., Pospisilik, J. Andrew, Deloukas, Pano, Frayling, Timothy M., Lettre, Guillaume, Mohlke, Karen L., Rotter, Jerome I., Kutalik, Zoltán, Hirschhorn, Joel N., Cupples, L. Adrienne, Loos, Ruth J. F., North, Kari E., Lindgren, Cecilia M., APH - Societal Participation & Health, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, Epidemiology and Data Science, and VU University medical center
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Exome/genetics ,Male ,ReproGen Consortium ,Adipose tissue ,Genome-wide association study ,Type 2 diabetes ,White adipose tissue ,Body Mass Index ,Animals ,Body Fat Distribution ,Case-Control Studies ,Drosophila ,Exome ,Female ,Gene Frequency ,Genetic Predisposition to Disease ,Genetic Variation ,Genome-Wide Association Study ,Homeostasis ,Humans ,Lipids ,Proteins ,Risk Factors ,Waist-Hip Ratio ,0302 clinical medicine ,Hyperlipidemia ,Body fat distribution ,2. Zero hunger ,Genetics ,0303 health sciences ,INSULIN-RESISTANCE ,ADIPOCYTE DIFFERENTIATION ,CHD Exome+ Consortium ,Genetic Predisposition to Disease/genetics ,Drosophila/genetics ,RS11209026 POLYMORPHISM ,KINASE 7 ,1184 Genetics, developmental biology, physiology ,T2D-Genes Consortium ,11 Medical And Health Sciences ,Body Fat Distribution/methods ,RECEPTOR ALK7 ,ADIPOSE-TISSUE ,Gene Frequency/genetics ,Genetic Variation/genetics ,InterAct ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,genetic association study ,RNA splicing ,Proteins/genetics ,Genome-Wide Association Study/methods ,Lipid particle ,ExomeBP Consortium ,WAIST CIRCUMFERENCE ,Waist-Hip Ratio/methods ,Biology ,EPIC-CVD Consortium ,Article ,MAGIC Investigators ,03 medical and health sciences ,Homeostasis/genetics ,Lipids/genetics ,All institutes and research themes of the Radboud University Medical Center ,medicine ,Global Lipids Genetic Consortium ,Risk factor ,GENOME-WIDE ASSOCIATION ,ABDOMINAL ADIPOSITY ,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium ,Gene ,030304 developmental biology ,06 Biological Sciences ,medicine.disease ,Minor allele frequency ,GoT2D Genes Consortium ,genetics research ,TYPE-2 DIABETES SUSCEPTIBILITY ,3111 Biomedicine ,Body mass index ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
Body fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥ 5%) and 9 low frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology, and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants., Editorial summary: A trans-ethnic exome-wide association study for body fat distribution identifies protein-coding variants that are significantly associated with waist-to-hip ratio adjusted for body mass index.
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44. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
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Heid, Iris M, Jackson, Anne U, Randall, Joshua C, Winkler, Thomas W, Qi, Lu, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Zillikens, M Carola, Speliotes, Elizabeth K, Mägi, Reedik, Workalemahu, Tsegaselassie, White, Charles C, Bouatia-Naji, Nabila, Harris, Tamara B, Berndt, Sonja I, Ingelsson, Erik, Willer, Cristen J, Weedon, Michael N, Luan, Jian'an, and Vedantam, Sailaja
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GENE frequency ,GENETIC polymorphisms ,SEXUAL dimorphism ,META-analysis - Abstract
Corrections to the article "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution" that was published in the October 10, 2011 issue are presented, such as the effect allele frequencies for eight single nucleotide polymorphisms (SNPs) that include rs984222, rs9491696, and rs4846567.
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- 2011
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45. Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
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Voight, Benjamin F., Scott, Laura J., Steinthorsdottir, Valgerdur, Morris, Andrew P., Dina, Christian, Welch, Ryan P., Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S., Thorleifsson, Gudmar, McCulloch, Laura J., Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J., Raychaudhuri, Soumya, McCarroll, Steve A., Langenberg, Claudia, and Hofmann, Oliver M.
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TYPE 2 diabetes - Abstract
A correction to the article "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis" that was published in the 2010 issue is presented.
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- 2011
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46. The impact of low-frequency and rare variants on lipid levels.
- Author
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Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, Kettunen J, Pirinen M, Karjalainen J, Thorleifsson G, Hägg S, Hottenga JJ, Isaacs A, Ladenvall C, Beekman M, Esko T, Ried JS, Nelson CP, Willenborg C, Gustafsson S, Westra HJ, Blades M, de Craen AJ, de Geus EJ, Deelen J, Grallert H, Hamsten A, Havulinna AS, Hengstenberg C, Houwing-Duistermaat JJ, Hyppönen E, Karssen LC, Lehtimäki T, Lyssenko V, Magnusson PK, Mihailov E, Müller-Nurasyid M, Mpindi JP, Pedersen NL, Penninx BW, Perola M, Pers TH, Peters A, Rung J, Smit JH, Steinthorsdottir V, Tobin MD, Tsernikova N, van Leeuwen EM, Viikari JS, Willems SM, Willemsen G, Schunkert H, Erdmann J, Samani NJ, Kaprio J, Lind L, Gieger C, Metspalu A, Slagboom PE, Groop L, van Duijn CM, Eriksson JG, Jula A, Salomaa V, Boomsma DI, Power C, Raitakari OT, Ingelsson E, Järvelin MR, Thorsteinsdottir U, Franke L, Ikonen E, Kallioniemi O, Pietiäinen V, Lindgren CM, Stefansson K, Palotie A, McCarthy MI, Morris AP, Prokopenko I, and Ripatti S
- Subjects
- Dyslipidemias genetics, Gene Frequency, Genetic Loci, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Mutation, Missense, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Lipid Metabolism genetics
- Abstract
Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, including 79 previously identified loci with new lead SNPs and 10 new loci, 15 loci with a low-frequency lead SNP and 10 loci with a missense lead SNP, and 2 loci with an accumulation of rare variants. In six loci, SNPs with established function in lipid genetics (CELSR2, GCKR, LIPC and APOE) or candidate missense mutations with predicted damaging function (CD300LG and TM6SF2) explained the locus associations. The low-frequency variants increased the proportion of variance explained, particularly for low-density lipoprotein cholesterol and total cholesterol. Altogether, our results highlight the impact of low-frequency variants in complex traits and show that imputation offers a cost-effective alternative to resequencing.
- Published
- 2015
- Full Text
- View/download PDF
47. Defining the role of common variation in the genomic and biological architecture of adult human height.
- Author
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Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC, Scherag A, Vinkhuyzen AA, Westra HJ, Winkler TW, Workalemahu T, Zhao JH, Absher D, Albrecht E, Anderson D, Baron J, Beekman M, Demirkan A, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Fraser RM, Goel A, Gong J, Justice AE, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Lui JC, Mangino M, Mateo Leach I, Medina-Gomez C, Nalls MA, Nyholt DR, Palmer CD, Pasko D, Pechlivanis S, Prokopenko I, Ried JS, Ripke S, Shungin D, Stancáková A, Strawbridge RJ, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Afzal U, Arnlöv J, Arscott GM, Bandinelli S, Barrett A, Bellis C, Bennett AJ, Berne C, Blüher M, Bolton JL, Böttcher Y, Boyd HA, Bruinenberg M, Buckley BM, Buyske S, Caspersen IH, Chines PS, Clarke R, Claudi-Boehm S, Cooper M, Daw EW, De Jong PA, Deelen J, Delgado G, Denny JC, Dhonukshe-Rutten R, Dimitriou M, Doney AS, Dörr M, Eklund N, Eury E, Folkersen L, Garcia ME, Geller F, Giedraitis V, Go AS, Grallert H, Grammer TB, Gräßler J, Grönberg H, de Groot LC, Groves CJ, Haessler J, Hall P, Haller T, Hallmans G, Hannemann A, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hemani G, Henders AK, Hillege HL, Hlatky MA, Hoffmann W, Hoffmann P, Holmen O, Houwing-Duistermaat JJ, Illig T, Isaacs A, James AL, Jeff J, Johansen B, Johansson Å, Jolley J, Juliusdottir T, Junttila J, Kho AN, Kinnunen L, Klopp N, Kocher T, Kratzer W, Lichtner P, Lind L, Lindström J, Lobbens S, Lorentzon M, Lu Y, Lyssenko V, Magnusson PK, Mahajan A, Maillard M, McArdle WL, McKenzie CA, McLachlan S, McLaren PJ, Menni C, Merger S, Milani L, Moayyeri A, Monda KL, Morken MA, Müller G, Müller-Nurasyid M, Musk AW, Narisu N, Nauck M, Nolte IM, Nöthen MM, Oozageer L, Pilz S, Rayner NW, Renstrom F, Robertson NR, Rose LM, Roussel R, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Schunkert H, Scott RA, Sehmi J, Seufferlein T, Shi J, Silventoinen K, Smit JH, Smith AV, Smolonska J, Stanton AV, Stirrups K, Stott DJ, Stringham HM, Sundström J, Swertz MA, Syvänen AC, Tayo BO, Thorleifsson G, Tyrer JP, van Dijk S, van Schoor NM, van der Velde N, van Heemst D, van Oort FV, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Waldenberger M, Wennauer R, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Bergmann S, Biffar R, Blangero J, Boomsma DI, Bornstein SR, Bovet P, Brambilla P, Brown MJ, Campbell H, Caulfield MJ, Chakravarti A, Collins R, Collins FS, Crawford DC, Cupples LA, Danesh J, de Faire U, den Ruijter HM, Erbel R, Erdmann J, Eriksson JG, Farrall M, Ferrannini E, Ferrières J, Ford I, Forouhi NG, Forrester T, Gansevoort RT, Gejman PV, Gieger C, Golay A, Gottesman O, Gudnason V, Gyllensten U, Haas DW, Hall AS, Harris TB, Hattersley AT, Heath AC, Hengstenberg C, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Jacobs KB, Jarvelin MR, Jousilahti P, Jula AM, Kaprio J, Kastelein JJ, Kayser M, Kee F, Keinanen-Kiukaanniemi SM, Kiemeney LA, Kooner JS, Kooperberg C, Koskinen S, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimäki T, Lupoli S, Madden PA, Männistö S, Manunta P, Marette A, Matise TC, McKnight B, Meitinger T, Moll FL, Montgomery GW, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Ouwehand WH, Pasterkamp G, Peters A, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ritchie M, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schwarz PE, Sebert S, Sever P, Shuldiner AR, Sinisalo J, Steinthorsdottir V, Stolk RP, Tardif JC, Tönjes A, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hayes MG, Hui J, Hunter DJ, Hveem K, Jukema JW, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, März W, Melbye M, Moebus S, Munroe PB, Njølstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Pérusse L, Peters U, Powell JE, Power C, Quertermous T, Rauramaa R, Reinmaa E, Ridker PM, Rivadeneira F, Rotter JI, Saaristo TE, Saleheen D, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Strauch K, Stumvoll M, Tuomilehto J, Uusitupa M, van der Harst P, Völzke H, Walker M, Wareham NJ, Watkins H, Wichmann HE, Wilson JF, Zanen P, Deloukas P, Heid IM, Lindgren CM, Mohlke KL, Speliotes EK, Thorsteinsdottir U, Barroso I, Fox CS, North KE, Strachan DP, Beckmann JS, Berndt SI, Boehnke M, Borecki IB, McCarthy MI, Metspalu A, Stefansson K, Uitterlinden AG, van Duijn CM, Franke L, Willer CJ, Price AL, Lettre G, Loos RJ, Weedon MN, Ingelsson E, O'Connell JR, Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, and Frayling TM
- Subjects
- Adult, Analysis of Variance, Genetics, Population, Genome-Wide Association Study methods, Humans, Oligonucleotide Array Sequence Analysis, Body Height genetics, Genetic Variation genetics, Polymorphism, Single Nucleotide genetics, White People genetics
- Abstract
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
- Published
- 2014
- Full Text
- View/download PDF
48. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.
- Author
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Flannick J, Thorleifsson G, Beer NL, Jacobs SB, Grarup N, Burtt NP, Mahajan A, Fuchsberger C, Atzmon G, Benediktsson R, Blangero J, Bowden DW, Brandslund I, Brosnan J, Burslem F, Chambers J, Cho YS, Christensen C, Douglas DA, Duggirala R, Dymek Z, Farjoun Y, Fennell T, Fontanillas P, Forsén T, Gabriel S, Glaser B, Gudbjartsson DF, Hanis C, Hansen T, Hreidarsson AB, Hveem K, Ingelsson E, Isomaa B, Johansson S, Jørgensen T, Jørgensen ME, Kathiresan S, Kong A, Kooner J, Kravic J, Laakso M, Lee JY, Lind L, Lindgren CM, Linneberg A, Masson G, Meitinger T, Mohlke KL, Molven A, Morris AP, Potluri S, Rauramaa R, Ribel-Madsen R, Richard AM, Rolph T, Salomaa V, Segrè AV, Skärstrand H, Steinthorsdottir V, Stringham HM, Sulem P, Tai ES, Teo YY, Teslovich T, Thorsteinsdottir U, Trimmer JK, Tuomi T, Tuomilehto J, Vaziri-Sani F, Voight BF, Wilson JG, Boehnke M, McCarthy MI, Njølstad PR, Pedersen O, Groop L, Cox DR, Stefansson K, and Altshuler D
- Subjects
- Animals, Base Sequence, Blood Glucose genetics, Genetic Association Studies, Genotype, Humans, Ion Transport genetics, Mice, Mice, Knockout, Molecular Sequence Data, Proinsulin blood, Sequence Analysis, DNA, Zinc Transporter 8, Cation Transport Proteins genetics, Diabetes Mellitus, Type 2 genetics, Mutation, Missense genetics
- Abstract
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10(-6)), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (-0.17 s.d., P = 4.6 × 10(-4)). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.
- Published
- 2014
- Full Text
- View/download PDF
49. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
- Author
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Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J, Bell GI, Benediktsson R, Bergman RN, Boehm BO, Boerwinkle E, Bonnycastle LL, Burtt N, Cai Q, Campbell H, Carey J, Cauchi S, Caulfield M, Chan JC, Chang LC, Chang TJ, Chang YC, Charpentier G, Chen CH, Chen H, Chen YT, Chia KS, Chidambaram M, Chines PS, Cho NH, Cho YM, Chuang LM, Collins FS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Danesh J, Das D, de Faire U, Dedoussis G, Deloukas P, Dimas AS, Dina C, Doney AS, Donnelly PJ, Dorkhan M, van Duijn C, Dupuis J, Edkins S, Elliott P, Emilsson V, Erbel R, Eriksson JG, Escobedo J, Esko T, Eury E, Florez JC, Fontanillas P, Forouhi NG, Forsen T, Fox C, Fraser RM, Frayling TM, Froguel P, Frossard P, Gao Y, Gertow K, Gieger C, Gigante B, Grallert H, Grant GB, Grrop LC, Groves CJ, Grundberg E, Guiducci C, Hamsten A, Han BG, Hara K, Hassanali N, Hattersley AT, Hayward C, Hedman AK, Herder C, Hofman A, Holmen OL, Hovingh K, Hreidarsson AB, Hu C, Hu FB, Hui J, Humphries SE, Hunt SE, Hunter DJ, Hveem K, Hydrie ZI, Ikegami H, Illig T, Ingelsson E, Islam M, Isomaa B, Jackson AU, Jafar T, James A, Jia W, Jöckel KH, Jonsson A, Jowett JB, Kadowaki T, Kang HM, Kanoni S, Kao WH, Kathiresan S, Kato N, Katulanda P, Keinanen-Kiukaanniemi KM, Kelly AM, Khan H, Khaw KT, Khor CC, Kim HL, Kim S, Kim YJ, Kinnunen L, Klopp N, Kong A, Korpi-Hyövälti E, Kowlessur S, Kraft P, Kravic J, Kristensen MM, Krithika S, Kumar A, Kumate J, Kuusisto J, Kwak SH, Laakso M, Lagou V, Lakka TA, Langenberg C, Langford C, Lawrence R, Leander K, Lee JM, Lee NR, Li M, Li X, Li Y, Liang J, Liju S, Lim WY, Lind L, Lindgren CM, Lindholm E, Liu CT, Liu JJ, Lobbens S, Long J, Loos RJ, Lu W, Luan J, Lyssenko V, Ma RC, Maeda S, Mägi R, Männisto S, Matthews DR, Meigs JB, Melander O, Metspalu A, Meyer J, Mirza G, Mihailov E, Moebus S, Mohan V, Mohlke KL, Morris AD, Mühleisen TW, Müller-Nurasyid M, Musk B, Nakamura J, Nakashima E, Navarro P, Ng PK, Nica AC, Nilsson PM, Njølstad I, Nöthen MM, Ohnaka K, Ong TH, Owen KR, Palmer CN, Pankow JS, Park KS, Parkin M, Pechlivanis S, Pedersen NL, Peltonen L, Perry JR, Peters A, Pinidiyapathirage JM, Platou CG, Potter S, Price JF, Qi L, Radha V, Rallidis L, Rasheed A, Rathman W, Rauramaa R, Raychaudhuri S, Rayner NW, Rees SD, Rehnberg E, Ripatti S, Robertson N, Roden M, Rossin EJ, Rudan I, Rybin D, Saaristo TE, Salomaa V, Saltevo J, Samuel M, Sanghera DK, Saramies J, Scott J, Scott LJ, Scott RA, Segrè AV, Sehmi J, Sennblad B, Shah N, Shah S, Shera AS, Shu XO, Shuldiner AR, Sigurđsson G, Sijbrands E, Silveira A, Sim X, Sivapalaratnam S, Small KS, So WY, Stančáková A, Stefansson K, Steinbach G, Steinthorsdottir V, Stirrups K, Strawbridge RJ, Stringham HM, Sun Q, Suo C, Syvänen AC, Takayanagi R, Takeuchi F, Tay WT, Teslovich TM, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tikkanen E, Trakalo J, Tremoli E, Trip MD, Tsai FJ, Tuomi T, Tuomilehto J, Uitterlinden AG, Valladares-Salgado A, Vedantam S, Veglia F, Voight BF, Wang C, Wareham NJ, Wennauer R, Wickremasinghe AR, Wilsgaard T, Wilson JF, Wiltshire S, Winckler W, Wong TY, Wood AR, Wu JY, Wu Y, Yamamoto K, Yamauchi T, Yang M, Yengo L, Yokota M, Young R, Zabaneh D, Zhang F, Zhang R, Zheng W, Zimmet PZ, Altshuler D, Bowden DW, Cho YS, Cox NJ, Cruz M, Hanis CL, Kooner J, Lee JY, Seielstad M, Teo YY, Boehnke M, Parra EJ, Chambers JC, Tai ES, McCarthy MI, and Morris AP
- Subjects
- Alleles, Asian People genetics, Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino genetics, Humans, Polymorphism, Single Nucleotide, Risk Factors, White People genetics, Diabetes Mellitus, Type 2 genetics
- Abstract
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.
- Published
- 2014
- Full Text
- View/download PDF
50. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
- Author
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Stacey SN, Sulem P, Jonasdottir A, Masson G, Gudmundsson J, Gudbjartsson DF, Magnusson OT, Gudjonsson SA, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Nexø BA, Tjønneland A, Overvad K, Rudnai P, Gurzau E, Koppova K, Hemminki K, Corredera C, Fuentelsaz V, Grasa P, Navarrete S, Fuertes F, García-Prats MD, Sanambrosio E, Panadero A, De Juan A, Garcia A, Rivera F, Planelles D, Soriano V, Requena C, Aben KK, van Rossum MM, Cremers RG, van Oort IM, van Spronsen DJ, Schalken JA, Peters WH, Helfand BT, Donovan JL, Hamdy FC, Badescu D, Codreanu O, Jinga M, Csiki IE, Constantinescu V, Badea P, Mates IN, Dinu DE, Constantin A, Mates D, Kristjansdottir S, Agnarsson BA, Jonsson E, Barkardottir RB, Einarsson GV, Sigurdsson F, Moller PH, Stefansson T, Valdimarsson T, Johannsson OT, Sigurdsson H, Jonsson T, Jonasson JG, Tryggvadottir L, Rice T, Hansen HM, Xiao Y, Lachance DH, O Neill BP, Kosel ML, Decker PA, Thorleifsson G, Johannsdottir H, Helgadottir HT, Sigurdsson A, Steinthorsdottir V, Lindblom A, Sandler RS, Keku TO, Banasik K, Jørgensen T, Witte DR, Hansen T, Pedersen O, Jinga V, Neal DE, Catalona WJ, Wrensch M, Wiencke J, Jenkins RB, Nagore E, Vogel U, Kiemeney LA, Kumar R, Mayordomo JI, Olafsson JH, Kong A, Thorsteinsdottir U, Rafnar T, and Stefansson K
- Subjects
- Humans, Polymorphism, Single Nucleotide, Tumor Suppressor Protein p53 genetics, Genetic Predisposition to Disease, Germ-Line Mutation, Neoplasms genetics, Tumor Suppressor Protein p53 metabolism
- Abstract
To identify new risk variants for cutaneous basal cell carcinoma, we performed a genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders. We imputed genotypes for 41,675 Illumina SNP chip-typed Icelanders and their relatives. In the discovery phase, the strongest signal came from rs78378222[C] (odds ratio (OR) = 2.36, P = 5.2 × 10(-17)), which has a frequency of 0.0192 in the Icelandic population. We then confirmed this association in non-Icelandic samples (OR = 1.75, P = 0.0060; overall OR = 2.16, P = 2.2 × 10(-20)). rs78378222 is in the 3' untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3'-end processing of TP53 mRNA. Investigation of other tumor types identified associations of this SNP with prostate cancer (OR = 1.44, P = 2.4 × 10(-6)), glioma (OR = 2.35, P = 1.0 × 10(-5)) and colorectal adenoma (OR = 1.39, P = 1.6 × 10(-4)). However, we observed no effect for breast cancer, a common Li-Fraumeni syndrome tumor (OR = 1.06, P = 0.57, 95% confidence interval 0.88-1.27).
- Published
- 2011
- Full Text
- View/download PDF
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