7 results on '"Surti, Aarti"'
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2. Common variants at 30 loci contribute to polygenic dyslipidemia
- Author
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Kathiresan, Sekar, primary, Willer, Cristen J, additional, Peloso, Gina M, additional, Demissie, Serkalem, additional, Musunuru, Kiran, additional, Schadt, Eric E, additional, Kaplan, Lee, additional, Bennett, Derrick, additional, Li, Yun, additional, Tanaka, Toshiko, additional, Voight, Benjamin F, additional, Bonnycastle, Lori L, additional, Jackson, Anne U, additional, Crawford, Gabriel, additional, Surti, Aarti, additional, Guiducci, Candace, additional, Burtt, Noel P, additional, Parish, Sarah, additional, Clarke, Robert, additional, Zelenika, Diana, additional, Kubalanza, Kari A, additional, Morken, Mario A, additional, Scott, Laura J, additional, Stringham, Heather M, additional, Galan, Pilar, additional, Swift, Amy J, additional, Kuusisto, Johanna, additional, Bergman, Richard N, additional, Sundvall, Jouko, additional, Laakso, Markku, additional, Ferrucci, Luigi, additional, Scheet, Paul, additional, Sanna, Serena, additional, Uda, Manuela, additional, Yang, Qiong, additional, Lunetta, Kathryn L, additional, Dupuis, Josée, additional, de Bakker, Paul I W, additional, O'Donnell, Christopher J, additional, Chambers, John C, additional, Kooner, Jaspal S, additional, Hercberg, Serge, additional, Meneton, Pierre, additional, Lakatta, Edward G, additional, Scuteri, Angelo, additional, Schlessinger, David, additional, Tuomilehto, Jaakko, additional, Collins, Francis S, additional, Groop, Leif, additional, Altshuler, David, additional, Collins, Rory, additional, Lathrop, G Mark, additional, Melander, Olle, additional, Salomaa, Veikko, additional, Peltonen, Leena, additional, Orho-Melander, Marju, additional, Ordovas, Jose M, additional, Boehnke, Michael, additional, Abecasis, Gonçalo R, additional, Mohlke, Karen L, additional, and Cupples, L Adrienne, additional
- Published
- 2008
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- View/download PDF
3. Erratum: Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- Author
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Kathiresan, Sekar, primary, Melander, Olle, additional, Guiducci, Candace, additional, Surti, Aarti, additional, Burtt, Noël P, additional, Rieder, Mark J, additional, Cooper, Gregory M, additional, Roos, Charlotta, additional, Voight, Benjamin F, additional, Havulinna, Aki S, additional, Wahlstrand, Björn, additional, Hedner, Thomas, additional, Corella, Dolores, additional, Tai, E Shyong, additional, Ordovas, Jose M, additional, Berglund, Göran, additional, Vartiainen, Erkki, additional, Jousilahti, Pekka, additional, Hedblad, Bo, additional, Taskinen, Marja-Riitta, additional, Newton-Cheh, Christopher, additional, Salomaa, Veikko, additional, Peltonen, Leena, additional, Groop, Leif, additional, Altshuler, David M, additional, and Orho-Melander, Marju, additional
- Published
- 2008
- Full Text
- View/download PDF
4. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
- Author
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Kathiresan, Sekar, primary, Melander, Olle, additional, Guiducci, Candace, additional, Surti, Aarti, additional, Burtt, Noël P, additional, Rieder, Mark J, additional, Cooper, Gregory M, additional, Roos, Charlotta, additional, Voight, Benjamin F, additional, Havulinna, Aki S, additional, Wahlstrand, Björn, additional, Hedner, Thomas, additional, Corella, Dolores, additional, Tai, E Shyong, additional, Ordovas, Jose M, additional, Berglund, Göran, additional, Vartiainen, Erkki, additional, Jousilahti, Pekka, additional, Hedblad, Bo, additional, Taskinen, Marja-Riitta, additional, Newton-Cheh, Christopher, additional, Salomaa, Veikko, additional, Peltonen, Leena, additional, Groop, Leif, additional, Altshuler, David M, additional, and Orho-Melander, Marju, additional
- Published
- 2008
- Full Text
- View/download PDF
5. Common variants at 30 loci contribute to polygenic dyslipidemia.
- Author
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Kathiresan, Sekar, Willer, Cristen J., Peloso, Gina M, Demissie, Serkalem, Musunuru, Kiran, Schadt, Eric E., Kaplan, Lee, Bennett, Derrick, Li, Yun, Tanaka, Toshiko, Voight, Benjamin F., Bonnycastle, Lori L., Jackson, Anne U., Crawford, Gabriel, Surti, Aarti, Guiducci, Candace, Burtt, Noel P., Parish, Sarah, Clarke, Robert, and Zelenika, Diana
- Subjects
LIPOPROTEINS ,BLOOD cholesterol ,TRIGLYCERIDES ,CARDIOVASCULAR diseases risk factors ,GENOMES ,NUCLEOTIDE sequence - Abstract
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 × 10
−8 ), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10−15 for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia. [ABSTRACT FROM AUTHOR]- Published
- 2009
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6. Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
- Author
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Kathiresan, Sekar, Melander, Olle, Guiducci, Candace, Surti, Aarti, Burtt, Noël P, Rieder, Mark J, Cooper, Gregory M, Roos, Charlotta, Voight, Benjamin F, Havulinna, Aki S, Wahlstrand, Björn, Hedner, Thomas, Corella, Dolores, Tai, E Shyong, Ordovas, Jose M, Berglund, Göran, Vartiainen, Erkki, Jousilahti, Pekka, Hedblad, Bo, and Taskinen, Marja-Riitta
- Subjects
LOW density lipoproteins - Abstract
A correction to the article "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans" is presented.
- Published
- 2008
- Full Text
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7. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
- Author
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Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall A, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser V, Epstein SE, Rader DJ, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, and Altshuler D
- Subjects
- Adult, Age of Onset, Algorithms, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, Mutation physiology, Myocardial Infarction epidemiology, Risk Factors, Gene Dosage, Myocardial Infarction genetics, Polymorphism, Single Nucleotide
- Abstract
We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) for association with early-onset myocardial infarction in 2,967 cases and 3,075 controls. We carried out replication in an independent sample with an effective sample size of up to 19,492. SNPs at nine loci reached genome-wide significance: three are newly identified (21q22 near MRPS6-SLC5A3-KCNE2, 6p24 in PHACTR1 and 2q33 in WDR12) and six replicated prior observations (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9). We tested 554 common copy number polymorphisms (>1% allele frequency) and none met the pre-specified threshold for replication (P < 10(-3)). We identified 8,065 rare CNVs but did not detect a greater CNV burden in cases compared to controls, in genes compared to the genome as a whole, or at any individual locus. SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk.
- Published
- 2009
- Full Text
- View/download PDF
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