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4 results on '"Tuck, Elizabeth"'

1. Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., and Vento-Tormo, Roser

Published
2021
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2. Author Correction: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, Handfield, Louis-François, Roberts, Kenny, Nikolakopoulou, Konstantina, Fernando, Ridma C., Gardner, Lucy, Woodhams, Benjamin, Arutyunyan, Anna, Polanski, Krzysztof, Hoo, Regina, Sancho-Serra, Carmen, Li, Tong, Kwakwa, Kwasi, Tuck, Elizabeth, Lorenzi, Valentina, Massalha, Hassan, Prete, Martin, Kleshchevnikov, Vitalii, Tarkowska, Aleksandra, Porter, Tarryn, Mazzeo, Cecilia Icoresi, van Dongen, Stijn, Dabrowska, Monika, Vaskivskyi, Vasyl, Mahbubani, Krishnaa T., Park, Jong-eun, Jimenez-Linan, Mercedes, Campos, Lia, Kiselev, Vladimir Yu., Lindskog, Cecilia, Ayuk, Paul, Prigmore, Elena, Stratton, Michael R., Saeb-Parsy, Kourosh, Moffett, Ashley, Moore, Luiza, Bayraktar, Omer A., Teichmann, Sarah A., Turco, Margherita Y., and Vento-Tormo, Roser

Published
2023
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3. Author Correction: Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

Author

Garcia-Alonso, Luz, primary, Handfield, Louis-François, additional, Roberts, Kenny, additional, Nikolakopoulou, Konstantina, additional, Fernando, Ridma C., additional, Gardner, Lucy, additional, Woodhams, Benjamin, additional, Arutyunyan, Anna, additional, Polanski, Krzysztof, additional, Hoo, Regina, additional, Sancho-Serra, Carmen, additional, Li, Tong, additional, Kwakwa, Kwasi, additional, Tuck, Elizabeth, additional, Lorenzi, Valentina, additional, Massalha, Hassan, additional, Prete, Martin, additional, Kleshchevnikov, Vitalii, additional, Tarkowska, Aleksandra, additional, Porter, Tarryn, additional, Mazzeo, Cecilia Icoresi, additional, van Dongen, Stijn, additional, Dabrowska, Monika, additional, Vaskivskyi, Vasyl, additional, Mahbubani, Krishnaa T., additional, Park, Jong-eun, additional, Jimenez-Linan, Mercedes, additional, Campos, Lia, additional, Kiselev, Vladimir Yu., additional, Lindskog, Cecilia, additional, Ayuk, Paul, additional, Prigmore, Elena, additional, Stratton, Michael R., additional, Saeb-Parsy, Kourosh, additional, Moffett, Ashley, additional, Moore, Luiza, additional, Bayraktar, Omer A., additional, Teichmann, Sarah A., additional, Turco, Margherita Y., additional, and Vento-Tormo, Roser, additional

Published
2022
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4. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm.

Author

Chetaille P, Preuss C, Burkhard S, Côté JM, Houde C, Castilloux J, Piché J, Gosset N, Leclerc S, Wünnemann F, Thibeault M, Gagnon C, Galli A, Tuck E, Hickson GR, El Amine N, Boufaied I, Lemyre E, de Santa Barbara P, Faure S, Jonzon A, Cameron M, Dietz HC, Gallo-McFarlane E, Benson DW, Moreau C, Labuda D, Zhan SH, Shen Y, Jomphe M, Jones SJ, Bakkers J, and Andelfinger G

Subjects
Animals, Arrhythmias, Cardiac pathology, Cell Cycle genetics, Enteric Nervous System pathology, Fibroblasts, Founder Effect, Gastrointestinal Tract physiopathology, Gene Knockdown Techniques, Humans, Intestinal Diseases physiopathology, Karyotyping, Muscle Contraction genetics, Muscle, Smooth, Vascular pathology, Mutation genetics, Quebec, Syndrome, Transforming Growth Factor beta metabolism, Zebrafish, Cohesins, Abnormalities, Multiple genetics, Arrhythmias, Cardiac genetics, Cell Cycle Proteins genetics, Chromosomal Proteins, Non-Histone genetics, Intestinal Diseases genetics, Muscle Contraction physiology, Signal Transduction genetics
Abstract

The pacemaking activity of specialized tissues in the heart and gut results in lifelong rhythmic contractions. Here we describe a new syndrome characterized by Chronic Atrial and Intestinal Dysrhythmia, termed CAID syndrome, in 16 French Canadians and 1 Swede. We show that a single shared homozygous founder mutation in SGOL1, a component of the cohesin complex, causes CAID syndrome. Cultured dermal fibroblasts from affected individuals showed accelerated cell cycle progression, a higher rate of senescence and enhanced activation of TGF-β signaling. Karyotypes showed the typical railroad appearance of a centromeric cohesion defect. Tissues derived from affected individuals displayed pathological changes in both the enteric nervous system and smooth muscle. Morpholino-induced knockdown of sgol1 in zebrafish recapitulated the abnormalities seen in humans with CAID syndrome. Our findings identify CAID syndrome as a novel generalized dysrhythmia, suggesting a new role for SGOL1 and the cohesin complex in mediating the integrity of human cardiac and gut rhythm.

Published
2014
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