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Your search keyword '"Vicario, José L."' showing total 4 results
Start Over Author "Vicario, José L." Journal nature genetics
4 results on '"Vicario, José L."'

1. Erratum: Corrigendum: Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Author

Hor, Hyun, primary, Kutalik, Zoltán, additional, Dauvilliers, Yves, additional, Valsesia, Armand, additional, Lammers, Gert J, additional, Donjacour, Claire E H M, additional, Iranzo, Alex, additional, Santamaria, Joan, additional, Adrados, Rosa Peraita, additional, Vicario, José L, additional, Overeem, Sebastiaan, additional, Arnulf, Isabelle, additional, Theodorou, Ioannis, additional, Jennum, Poul, additional, Knudsen, Stine, additional, Bassetti, Claudio, additional, Mathis, Johannes, additional, Lecendreux, Michel, additional, Mayer, Geert, additional, Geisler, Peter, additional, Benetó, Antonio, additional, Petit, Brice, additional, Pfister, Corinne, additional, Bürki, Julie Vienne, additional, Didelot, Gérard, additional, Billiard, Michel, additional, Ercilla, Guadalupe, additional, Verduijn, Willem, additional, Claas, Frans H J, additional, Vollenwider, Peter, additional, Waeber, Gerard, additional, Waterworth, Dawn M, additional, Mooser, Vincent, additional, Heinzer, Raphaël, additional, Beckmann, Jacques S, additional, Bergmann, Sven, additional, and Tafti, Mehdi, additional

Published
2011
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2. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy

Author

Hor, Hyun, primary, Kutalik, Zoltán, additional, Dauvilliers, Yves, additional, Valsesia, Armand, additional, Lammers, Gert J, additional, Donjacour, Claire E H M, additional, Iranzo, Alex, additional, Santamaria, Joan, additional, Peraita Adrados, Rosa, additional, Vicario, José L, additional, Overeem, Sebastiaan, additional, Arnulf, Isabelle, additional, Theodorou, Ioannis, additional, Jennum, Poul, additional, Knudsen, Stine, additional, Bassetti, Claudio, additional, Mathis, Johannes, additional, Lecendreux, Michel, additional, Mayer, Geert, additional, Geisler, Peter, additional, Benetó, Antonio, additional, Petit, Brice, additional, Pfister, Corinne, additional, Bürki, Julie Vienne, additional, Didelot, Gérard, additional, Billiard, Michel, additional, Ercilla, Guadalupe, additional, Verduijn, Willem, additional, Claas, Frans H J, additional, Vollenweider, Peter, additional, Waeber, Gerard, additional, Waterworth, Dawn M, additional, Mooser, Vincent, additional, Heinzer, Raphaël, additional, Beckmann, Jacques S, additional, Bergmann, Sven, additional, and Tafti, Mehdi, additional

Published
2010
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3. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.

Author

Hyun Hor, Kutalik3,4, Zoltán, Dauvilliers, Yves, Valsesia, Armand, Lammers, Gert J., Donjacour, Claire E. H. M., Iranzo, Alex, Santamaria, Joan, Adrados, Rosa Peraita, Vicario, José L., Overeem, Sebastiaan, Arnulf, Isabelle, Theodorou, Ioannis, Jennum, Poul, Knudsen, Stine, Bassetti, Claudio, Mathis, Johannes, Lecendreux, Michel, Mayer, Geert, and Geisler, Peter

Subjects
HLA histocompatibility antigens, NARCOLEPSY, GENOMES, GENETICS education, CLINICAL trials
Abstract

Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association ever reported. Since the associated HLA-DRB1*1501-DQB1*0602 haplotype is common in the general population (15–25%), it has been suggested that it is almost necessary but not sufficient for developing narcolepsy. To further define the genetic basis of narcolepsy risk, we performed a genome-wide association study (GWAS) in 562 European individuals with narcolepsy (cases) and 702 ethnically matched controls, with independent replication in 370 cases and 495 controls, all heterozygous for DRB1*1501-DQB1*0602. We found association with a protective variant near HLA-DQA2 (rs2858884; P < 3 × 10−8). Further analysis revealed that rs2858884 is strongly linked to DRB1*03-DQB1*02 (P < 4 × 10−43) and DRB1*1301-DQB1*0603 (P < 3 × 10−7). Cases almost never carried a trans DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 × 10−14). This unexpected protective HLA haplotype suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility. [ABSTRACT FROM AUTHOR]

Published
2010
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4. Corrigendum: Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.

Author

Hor, Hyun, Kutalik, Zoltán, Dauvilliers, Yves, Valsesia, Armand, Lammers, Gert J., Donjacour, Claire E. H. M., Iranzo, Alex, Santamaria, Joan, Adrados, Rosa Peraita, Vicario, José L., Overeem, Sebastiaan, Arnulf, Isabelle, Theodorou, Ioannis, Jennum, Poul, Knudsen, Stine, Bassetti, Claudio, Mathis, Johannes, Lecendreux, Michel, Mayer, Geert, and Geisler, Peter

Subjects
POLITICAL affiliation
Abstract

A correction to the article "Genome-wide Association Study Identifies New HLA Class II Haplotypes Strongly Protective Against Narcolepsy" that was published in the October 27, 2010 issue is presented.

Published
2011
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