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Your search keyword '"van der Weyden, Louise"' showing total 5 results
Start Over Author "van der Weyden, Louise" Journal nature genetics
5 results on '"van der Weyden, Louise"'

2. Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

Author

March, H Nikki, primary, Rust, Alistair G, additional, Wright, Nicholas A, additional, ten Hoeve, Jelle, additional, de Ridder, Jeroen, additional, Eldridge, Matthew, additional, van der Weyden, Louise, additional, Berns, Anton, additional, Gadiot, Jules, additional, Uren, Anthony, additional, Kemp, Richard, additional, Arends, Mark J, additional, Wessels, Lodewyk F A, additional, Winton, Douglas J, additional, and Adams, David J, additional

Published
2011
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3. TranscriptSNPView: a genome-wide catalog of mouse coding variation

Author

Cunningham, Fiona, primary, Rios, Daniel, additional, Griffiths, Mark, additional, Smith, James, additional, Ning, Zemin, additional, Cox, Tony, additional, Flicek, Paul, additional, Marin-Garcin, Pablo, additional, Herrero, Javier, additional, Rogers, Jane, additional, van der Weyden, Louise, additional, Bradley, Allan, additional, Birney, Ewan, additional, and Adams, David J, additional

Published
2006
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4. Mutagenic Insertion and Chromosome Engineering Resource (MICER)

Author

Adams, David J, primary, Biggs, Patrick J, additional, Cox, Tony, additional, Davies, Rob, additional, van der Weyden, Louise, additional, Jonkers, Jos, additional, Smith, James, additional, Plumb, Bob, additional, Taylor, Ruth, additional, Nishijima, Ichiko, additional, Yu, Yuejin, additional, Rogers, Jane, additional, and Bradley, Allan, additional

Published
2004
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5. Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Author

Crossan, Gerry P., van der Weyden, Louise, Rosado, Ivan V., Langevin, Frederic, Gaillard, Pierre-Henri L, McIntyre, Rebecca E, Gallagher, Ferdia, Kettunen, Mikko I., Lewis, David Y., Brindle, Kevin, Arends, Mark J., Adams, David J., and Patel, Ketan J.

Subjects
*ENDONUCLEASES, *FANCONI'S anemia, *DNA damage, *COMPLEMENTATION (Genetics), *PROTEIN crosslinking, *LABORATORY mice, *GENETICS
Abstract

The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease complexes mediate repair during replication and can also resolve Holliday junctions formed during homologous recombination. Here we describe the phenotype of the Btbd12 knockout mouse, the mouse ortholog of SLX4, which recapitulates many key features of the human genetic illness Fanconi anemia. Btbd12-deficient animals are born at sub-Mendelian ratios, have greatly reduced fertility, are developmentally compromised and are prone to blood cytopenias. Btbd12−/− cells prematurely senesce, spontaneously accumulate damaged chromosomes and are particularly sensitive to DNA crosslinking agents. Genetic complementation reveals a crucial requirement for Btbd12 (also known as Slx4) to interact with the structure-specific endonuclease Xpf-Ercc1 to promote crosslink repair. The Btbd12 knockout mouse therefore establishes a disease model for Fanconi anemia and genetically links a regulator of nuclease incision complexes to the Fanconi anemia DNA crosslink repair pathway. [ABSTRACT FROM AUTHOR]

Published
2011
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