1. BCL-6 regulates chemokine gene transcription in macrophages.
- Author
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Toney, Lisa M., Cattoretti, Giorgio, Graf, Jennifer A., Merghoub, Taha, Pandolfi, Pier-Paolo, Dalla-Favera, Riccardo, Ye, B. Hilda, and Dent, Alexander L.
- Subjects
T cells ,GENETIC repressors ,INFLAMMATION ,MACROPHAGES - Abstract
The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (T
H 2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH 2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH 2-type inflammation by BCL-6 and link TH 2 differentiation to innate immunity. [ABSTRACT FROM AUTHOR]- Published
- 2000
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