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Your search keyword '"Dent, Alexander L."' showing total 3 results
Start Over Author "Dent, Alexander L." Journal nature immunology Publisher springer nature
3 results on '"Dent, Alexander L."'

1. It takes CK2 to suppress TH2.

Author

Sawant, Deepali V and Dent, Alexander L

Subjects
*SERINE/THREONINE kinases, *IMMUNOSUPPRESSION, *TH2 cells, *GENE expression, *CELLULAR immunity, *CELLULAR signal transduction, *ANTI-inflammatory agents, *CELLULAR control mechanisms
Published
2015
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3. BCL-6 regulates chemokine gene transcription in macrophages.

Author

Toney, Lisa M., Cattoretti, Giorgio, Graf, Jennifer A., Merghoub, Taha, Pandolfi, Pier-Paolo, Dalla-Favera, Riccardo, Ye, B. Hilda, and Dent, Alexander L.

Subjects
*T cells, *GENETIC repressors, *INFLAMMATION, *MACROPHAGES
Abstract

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity. [ABSTRACT FROM AUTHOR]

Published
2000
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