Search

Your search keyword '"Albert, Matthew L."' showing total 10 results
Start Over Author "Albert, Matthew L." Journal nature immunology
10 results on '"Albert, Matthew L."'

1. Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

Author

Barreira da Silva, Rosa, Leitao, Ricardo M., Pechuan-Jorge, Ximo, Werneke, Scott, Oeh, Jason, Javinal, Vincent, Wang, Yingyun, Phung, Wilson, Everett, Christine, Nonomiya, Jim, Arnott, David, Lu, Cheng, Hsiao, Yi-Chun, Koerber, James T., Hötzel, Isidro, Ziai, James, Modrusan, Zora, Pillow, Thomas H., Roose-Girma, Merone, Schartner, Jill M., Merchant, Mark, Rutz, Sascha, Eidenschenk, Céline, Mellman, Ira, and Albert, Matthew L.

Published
2022
Full Text
View/download PDF

3. Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Author

Patin, Etienne, Hasan, Milena, Bergstedt, Jacob, Rouilly, Vincent, Libri, Valentina, Urrutia, Alejandra, Alanio, Cécile, Scepanovic, Petar, Hammer, Christian, Jönsson, Friederike, Beitz, Benoît, Quach, Hélène, Lim, Yoong Wearn, Hunkapiller, Julie, Zepeda, Magge, Green, Cherie, Piasecka, Barbara, Leloup, Claire, Rogge, Lars, Huetz, François, Peguillet, Isabelle, Lantz, Olivier, Fontes, Magnus, Di Santo, James P., Thomas, Stéphanie, Fellay, Jacques, Duffy, Darragh, Quintana-Murci, Lluís, Albert, Matthew L., and The Milieu Intérieur Consortium

Published
2018
Full Text
View/download PDF

5. Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Author

Patin, Etienne, Hasan, Milena, Bergstedt, Jacob, Rouilly, Vincent, Libri, Valentina, Urrutia, Alejandra, Alanio, Cécile, Scepanovic, Petar, Hammer, Christian, Jönsson, Friederike, Beitz, Benoît, Quach, Hélène, Lim, Yoong Wearn, Hunkapiller, Julie, Zepeda, Magge, Green, Cherie, Piasecka, Barbara, Leloup, Claire, Rogge, Lars, Huetz, François, Peguillet, Isabelle, Lantz, Olivier, Fontes, Magnus, Di Santo, James P., Thomas, Stéphanie, Fellay, Jacques, Duffy, Darragh, Quintana-Murci, Lluís, Albert, Matthew L., and The Milieu Intérieur Consortium

Published
2018
Full Text
View/download PDF

6. Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

Author

Decque, Adrien, primary, Joffre, Olivier, additional, Magalhaes, Joao G, additional, Cossec, Jack-Christophe, additional, Blecher-Gonen, Ronnie, additional, Lapaquette, Pierre, additional, Silvin, Aymeric, additional, Manel, Nicolas, additional, Joubert, Pierre-Emmanuel, additional, Seeler, Jacob-Sebastian, additional, Albert, Matthew L, additional, Amit, Ido, additional, Amigorena, Sebastian, additional, and Dejean, Anne, additional

Published
2015
Full Text
View/download PDF

8. Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy.

Author

Barreira da Silva, Rosa, Laird, Melissa E, Yatim, Nader, Fiette, Laurence, Ingersoll, Molly A, and Albert, Matthew L

Subjects
CD26 antigen, LYMPHOCYTES, NATURAL immunity, IMMUNOTHERAPY, TUMOR immunology, ANTINEOPLASTIC agents, IMMUNE response
Abstract

The success of antitumor immune responses depends on the infiltration of solid tumors by effector T cells, a process guided by chemokines. Here we show that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10 and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide direct in vivo evidence for control of lymphocyte trafficking via CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing biologically active forms of chemokines as a strategy to enhance tumor immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

10. Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells.

Author

Albert, Matthew L., Jegathesan, Mithila, and Darnell, Robert B.

Subjects
*IMMUNOLOGICAL tolerance, *DENDRITIC cells, *PHAGOCYTOSIS, *APOPTOSIS, *CD antigens
Abstract

In vivo models have shown that tissue-restricted antigen may be captured by bone marrow?derived cells and cross-presented for the tolerization of CD8+ T cells. Although these studies have shown peripheral tolerization of CD8+ T cells, the mechanism of antigen transfer and the nature of the antigen-presenting cell (APC) remain undefined. We report here the establishment of an in vitro system for the study of cross-tolerance and show that dendritic cells (DCs) phagocytose apoptotic cells and tolerize antigen-specific CD8+ T cells when cognate CD4+ T helper cells are absent. Using this system, we directly tested the “two-signal” hypothesis for the regulation of priming versus tolerance. We found that the same CD83+ myeloid-derived DCs were required for both cross-priming and cross-tolerance. These data suggested that the current model for peripheral T cell tolerance, “signal 1 in the absence of signal 2”, requires refinement: the critical checkpoint is not DC maturation, but instead the presence of a third signal, which is active at the DC?CD4+ T cell interface. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results