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Your search keyword '"Graham, Gerard J."' showing total 5 results
Start Over Author "Graham, Gerard J." Journal nature immunology
5 results on '"Graham, Gerard J."'

1. New nomenclature for atypical chemokine receptors

Author

Bachelerie, Françoise, primary, Graham, Gerard J, additional, Locati, Massimo, additional, Mantovani, Alberto, additional, Murphy, Philip M, additional, Nibbs, Robert, additional, Rot, Antal, additional, Sozzani, Silvano, additional, and Thelen, Marcus, additional

Published
2014
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5. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity.

Author

Pruenster, Monika, Mudde, Liesbeth, Bombosi, Paula, Dimitrova, Svetla, Zsak, Marion, Middleton, Jim, Richmond, Ann, Graham, Gerard J, Segerer, Stephan, Nibbs, Robert J B, and Rot, Antal

Abstract

The Duffy antigen receptor for chemokines (DARC) belongs to a family of 'silent' heptahelical chemokine receptors that do not couple to G proteins and fail to transmit measurable intracellular signals. DARC binds most inflammatory chemokines and is prominently expressed on venular endothelial cells, where its function has remained contentious. Here we show that DARC, like other silent receptors, internalized chemokines but did not effectively scavenge them. Instead, DARC mediated chemokine transcytosis, which led to apical retention of intact chemokines and more leukocyte migration across monolayers expressing DARC. Mice overexpressing DARC on blood vessel endothelium had enhanced chemokine-induced leukocyte extravasation and contact-hypersensitivity reactions. Thus, interactions of chemokines with DARC support their activity on apposing leukocytes in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2009
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