Search

Your search keyword '"Clatworthy, Menna R."' showing total 4 results
Start Over Author "Clatworthy, Menna R." Journal nature medicine
4 results on '"Clatworthy, Menna R."'

1. Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Author

Uzzan, Mathieu, Martin, Jerome C., Mesin, Luka, Livanos, Alexandra E., Castro-Dopico, Tomas, Huang, Ruiqi, Petralia, Francesca, Magri, Giuliana, Kumar, Shashi, Zhao, Qing, Rosenstein, Adam K., Tokuyama, Minami, Sharma, Keshav, Ungaro, Ryan, Kosoy, Roman, Jha, Divya, Fischer, Jeremy, Singh, Harpriya, Keir, Mary E., Ramamoorthi, Nandhini, Gorman, William E. O’, Cohen, Benjamin L., Rahman, Adeeb, Cossarini, Francesca, Seki, Akihiro, Leyre, Louise, Vaquero, Sonia Tejedor, Gurunathan, Sakteesh, Grasset, Emilie K., Losic, Bojan, Dubinsky, Marla, Greenstein, Alexander J., Gottlieb, Zoe, Legnani, Peter, George, James, Irizar, Haritz, Stojmirovic, Aleksandar, Brodmerkel, Carrie, Kasarkis, Andrew, Sands, Bruce E., Furtado, Glaucia, Lira, Sergio A., Tuong, Zewen K., Ko, Huaibin M., Cerutti, Andrea, Elson, Charles O., Clatworthy, Menna R., Merad, Miriam, Suárez-Fariñas, Mayte, Argmann, Carmen, Hackney, Jason A., Victora, Gabriel D., Randolph, Gwendalyn J., Kenigsberg, Ephraim, Colombel, Jean Frederic, and Mehandru, Saurabh

Published
2022
Full Text
View/download PDF

2. Single-cell multi-omics analysis of the immune response in COVID-19

Author

Stephenson, Emily, Reynolds, Gary, Botting, Rachel A., Calero-Nieto, Fernando J., Morgan, Michael D., Tuong, Zewen Kelvin, Bach, Karsten, Sungnak, Waradon, Worlock, Kaylee B., Yoshida, Masahiro, Kumasaka, Natsuhiko, Kania, Katarzyna, Engelbert, Justin, Olabi, Bayanne, Spegarova, Jarmila Stremenova, Wilson, Nicola K., Mende, Nicole, Jardine, Laura, Gardner, Louis C. S., Goh, Issac, Horsfall, Dave, McGrath, Jim, Webb, Simone, Mather, Michael W., Lindeboom, Rik G. H., Dann, Emma, Huang, Ni, Polanski, Krzysztof, Prigmore, Elena, Gothe, Florian, Scott, Jonathan, Payne, Rebecca P., Baker, Kenneth F., Hanrath, Aidan T., Schim van der Loeff, Ina C. D., Barr, Andrew S., Sanchez-Gonzalez, Amada, Bergamaschi, Laura, Mescia, Federica, Barnes, Josephine L., Kilich, Eliz, de Wilton, Angus, Saigal, Anita, Saleh, Aarash, Janes, Sam M., Smith, Claire M., Gopee, Nusayhah, Wilson, Caroline, Coupland, Paul, Coxhead, Jonathan M., Kiselev, Vladimir Yu, van Dongen, Stijn, Bacardit, Jaume, King, Hamish W., Rostron, Anthony J., Simpson, A. John, Hambleton, Sophie, Laurenti, Elisa, Lyons, Paul A., Meyer, Kerstin B., Nikolić, Marko Z., Duncan, Christopher J. A., Smith, Kenneth G. C., Teichmann, Sarah A., Clatworthy, Menna R., Marioni, John C., Göttgens, Berthold, and Haniffa, Muzlifah

Subjects
Proteome, COVID-19, Cross-Sectional Studies, Humans, Monocytes, Receptors, Antigen, B-Cell, Receptors, Antigen, T-Cell, SARS-CoV-2, Single-Cell Analysis, T-Lymphocytes, Transcriptome, CD34, Biology, Peripheral blood mononuclear cell, Article, General Biochemistry, Genetics and Molecular Biology, Immune system, Antigen, Receptors, Platelet activation, Progenitor cell, B-Cell, RNA sequencing, General Medicine, T-Cell, Haematopoiesis, Viral infection, Immunology, Infection, CD8
Abstract

Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19. We identified expansion of nonclassical monocytes expressing complement transcripts (CD16+C1QA/B/C+) that sequester platelets and were predicted to replenish the alveolar macrophage pool in COVID-19. Early, uncommitted CD34+ hematopoietic stem/progenitor cells were primed toward megakaryopoiesis, accompanied by expanded megakaryocyte-committed progenitors and increased platelet activation. Clonally expanded CD8+ T cells and an increased ratio of CD8+ effector T cells to effector memory T cells characterized severe disease, while circulating follicular helper T cells accompanied mild disease. We observed a relative loss of IgA2 in symptomatic disease despite an overall expansion of plasmablasts and plasma cells. Our study highlights the coordinated immune response that contributes to COVID-19 pathogenesis and reveals discrete cellular components that can be targeted for therapy., Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

Published
2021
Full Text
View/download PDF

3. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

Author

Clatworthy, Menna R., Aronin, Caren E. Petrie, Mathews, Rebeccah J., Morgan, Nicole Y., Smith, Kenneth G.C., and Germain, Ronald N.

Subjects
Chemokine receptors -- Physiological aspects -- Genetic aspects -- Research, Immune response -- Physiological aspects -- Genetic aspects -- Research, Cell migration -- Physiological aspects -- Genetic aspects -- Research, Dendritic cells -- Physiological aspects -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Antibodies are critical for defense against a variety of microbes, but they may also be pathogenic in some autoimmune diseases. Many effector functions of antibodies are mediated by Fcg receptors (FcγRs), which are found on most immune cells, including dendritic cells (DCs)--important antigen-presenting cells that play a central role in inducing antigen-specific tolerance or immunity (1,2). Following antigen acquisition in peripheral tissues, DCs migrate to draining lymph nodes via the lymphatics to present antigen to T cells. Here we demonstrate that FcγR engagement by IgG immune complexes (ICs) stimulates DC migration from peripheral tissues to the paracortex of draining lymph nodes. In vitro, IC-stimulated mouse and human DCs showed greater directional migration in a chemokine (C-C) ligand 19 (CCL19) gradient and increased chemokine (C-C) receptor 7 (CCR7) expression. Using intravital two-photon microscopy, we observed that local administration of IC resulted in dermal DC mobilization. We confirmed that dermal DC migration to lymph nodes depended on CCR7 and increased in the absence of the inhibitory receptor FcγRIIB. These observations have relevance to autoimmunity because autoantibody-containing serum from humans with systemic lupus erythematosus (SLE) and from a mouse model of SLE also increased dermal DC migration in vivo, suggesting that this process may occur in lupus, potentially driving the inappropriate localization of autoantigen-bearing DCs., Antibodies have direct protective effects via pathogen or toxin neutralization and can activate complement or ligate Fc receptors (3,4). FcγRs bind immune-complexed IgG and include activating receptors (in humans: FcγRIIA, [...]

Published
2014

4. Loss of function of a lupus-associated Fc[gamma]RIIb polymorphism through exclusion from lipid rafts

Author

Floto, R Andres, Clatworthy, Menna R, Heilbronn, Karen R, Rosner, Dalya R, MacAry, Paul A, Rankin, Angela, Lehner, Paul J, Ouwehand, Willem H, Allen, Janet M, Watkins, Nicholas A, and Smith, Kenneth G C

Abstract

Author(s): R Andres Floto (corresponding author) [1, 4]; Menna R Clatworthy [1, 4]; Karen R Heilbronn [1]; Dalya R Rosner [1]; Paul A MacAry [1]; Angela Rankin [2]; Paul J [...]

Published
2005
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results