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2 results on '"John W. Stokes"'

1. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

Author

Andrew Tumen, Rei Ukita, Kenmond Fung, Jinho Kim, Ya-Wen Chen, Jonathan A. Reimer, Brandon A. Guenthart, Ahmed E. Hozain, Rachel Donocoff, Edward C. Ruiz, Katherine M. Cunningham, Hans-Willem Snoeck, Nancy L. Cardwell, Michael T. Simpson, Dawn Queen, Alexander Romanov, Meghan R. Pinezich, Yuliya Tipograf, Charles C. Marboe, John W. Stokes, Jennifer Talackine, John D. O’Neill, Matthew Bacchetta, Adam Griesemer, and Gordana Vunjak-Novakovic

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Lung, business.industry, medicine.medical_treatment, General Medicine, Cross Circulation, respiratory system, General Biochemistry, Genetics and Molecular Biology, Poor quality, Extracorporeal, respiratory tract diseases, Transplantation, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Marginal (quality), Medicine, Lung transplantation, business, Whole blood
Abstract

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal quality donor lungs, extension of normothermic support beyond 6 h has been challenging. Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering. In a new strategy for increasing the availability of lungs for transplantation, human lungs declined for transplantation because of their poor quality can be recuperated by connecting them to the circulation of a pig.

Published
2020

2. Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

Author

Ahmed E, Hozain, John D, O'Neill, Meghan R, Pinezich, Yuliya, Tipograf, Rachel, Donocoff, Katherine M, Cunningham, Andrew, Tumen, Kenmond, Fung, Rei, Ukita, Michael T, Simpson, Jonathan A, Reimer, Edward C, Ruiz, Dawn, Queen, John W, Stokes, Nancy L, Cardwell, Jennifer, Talackine, Jinho, Kim, Hans-Willem, Snoeck, Ya-Wen, Chen, Alexander, Romanov, Charles C, Marboe, Adam D, Griesemer, Brandon A, Guenthart, Matthew, Bacchetta, and Gordana, Vunjak-Novakovic

Subjects
Perfusion, Extracorporeal Circulation, Swine, Acute Lung Injury, Animals, Humans, Organ Preservation, Lung, Tissue Donors, Lung Transplantation
Abstract

Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal quality donor lungs, extension of normothermic support beyond 6 h has been challenging. Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering.

Published
2019

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