1. Miscarriage and Stillbirth Following Maternal Zika Virus Infection in Nonhuman Primates
- Author
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Rudolf P. Bohm, David H. O’Connor, Michael Gale, Lakshmi Rajagopal, Claudia Sanchez San Martin, Jean L. Patterson, Heather A. Simmons, Amir Ardeshir, Manasi Tamhankar, Rhonda MacAllister, Ronald S. Veazey, Nicholas J. Maness, Suzette D. Tardif, Kristina M. Adams Waldorf, Dawn M. Dudley, Andres Mejia, Saverio Capuano, Xiaolei Wang, Daniel N. Streblow, Charlotte E. Hotchkiss, Emma L. Mohr, Lark L. Coffey, Koen K. A. Van Rompay, Heidi L. Pecoraro, Lois M. A. Colgin, Alec J. Hirsch, Travis Hodge, Antonito T. Panganiban, Thaddeus G. Golos, Thomas C. Friedrich, Rebekah I. Keesler, Margaret H. Gilbert, Eliza Bliss-Moreau, Kjersti Aagaard, Rosemary J. Steinbach, Charles Y. Chiu, Peta L. Grigsby, and Maxim Seferovic
- Subjects
0301 basic medicine ,Male ,Primates ,medicine.medical_specialty ,Adverse outcomes ,Kaplan-Meier Estimate ,Abortion ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,Article ,Miscarriage ,Zika virus ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,medicine ,Animals ,030212 general & internal medicine ,biology ,business.industry ,Obstetrics ,Zika Virus Infection ,General Medicine ,Zika Virus ,Stillbirth ,biology.organism_classification ,medicine.disease ,3. Good health ,Abortion, Spontaneous ,Rhesus macaque ,030104 developmental biology ,Fetal Demise ,Female ,medicine.symptom ,business - Abstract
Zika virus (ZIKV) infection in humans has been associated with severe congenital defects (i.e. microcephaly) and pregnancy loss. Here we show that 26% of nonhuman primates infected with Asian/American ZIKV in early gestation experienced fetal demise later in pregnancy despite few clinical signs of infection. Pregnancy loss due to asymptomatic ZIKV infection may therefore be a common but under-recognized adverse outcome related to maternal ZIKV infection.
- Published
- 2018