1. Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
- Author
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Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, and Schrauwen P
- Subjects
- Adipose Tissue, Brown metabolism, Aged, Cold Temperature, Fluorodeoxyglucose F18, Glucose metabolism, Glucose Transporter Type 4 physiology, Humans, Male, Middle Aged, Acclimatization, Diabetes Mellitus, Type 2 metabolism, Insulin Resistance
- Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
- Published
- 2015
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