1. Coding of facial expressions of pain in the laboratory mouse
- Author
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Tammy Klassen-Ross, Tanya E Drummond, Sarah E Clarke, Jeffrey S. Mogil, Dale J. Langford, Stephanie Echols, Joelle Ingrao, Mona Lisa Chanda, Andrea L Bailey, John Tabaka, Michael L. LaCroix-Fralish, David H. W. Wong, Kenneth D. Craig, Robert E. Sorge, Sarah Glick, Arn M. J. M. van den Maagdenberg, Lynn C Matsumiya, Susana G. Sotocinal, and Michel D. Ferrari
- Subjects
medicine.medical_specialty ,Pain experience ,Facial expression ,Mice, Inbred ICR ,Behavioral coding ,business.industry ,Laboratory mouse ,Pain ,spared nerve injury neuropathic pain spreading depression incisional pain model migraine mice strains rat heritability ,Cell Biology ,Audiology ,Biochemistry ,Facial Expression ,Mice ,Noxious stimulus ,Medicine ,Pain psychology ,Animals ,business ,Molecular Biology ,Biotechnology ,Coding (social sciences) ,Pain Measurement - Abstract
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.
- Published
- 2010