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Your search keyword '"Möbius P"' showing total 8 results
Start Over Author "Möbius P" Journal nature neuroscience
8 results on '"Möbius P"'

1. Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Author

Asadollahi, Ebrahim, Trevisiol, Andrea, Saab, Aiman S., Looser, Zoe J., Dibaj, Payam, Ebrahimi, Reyhane, Kusch, Kathrin, Ruhwedel, Torben, Möbius, Wiebke, Jahn, Olaf, Lee, Jun Yup, Don, Anthony S., Khalil, Michelle-Amirah, Hiller, Karsten, Baes, Myriam, Weber, Bruno, Abel, E. Dale, Ballabio, Andrea, Popko, Brian, Kassmann, Celia M., Ehrenreich, Hannelore, Hirrlinger, Johannes, and Nave, Klaus-Armin

Published
2024
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2. Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Author

Sasmita, Andrew Octavian, Depp, Constanze, Nazarenko, Taisiia, Sun, Ting, Siems, Sophie B., Ong, Erinne Cherisse, Nkeh, Yakum B., Böhler, Carolin, Yu, Xuan, Bues, Bastian, Evangelista, Lisa, Mao, Shuying, Morgado, Barbara, Wu, Zoe, Ruhwedel, Torben, Subramanian, Swati, Börensen, Friederike, Overhoff, Katharina, Spieth, Lena, Berghoff, Stefan A., Sadleir, Katherine Rose, Vassar, Robert, Eggert, Simone, Goebbels, Sandra, Saito, Takashi, Saido, Takaomi, Saher, Gesine, Möbius, Wiebke, Castelo-Branco, Gonçalo, Klafki, Hans-Wolfgang, Wirths, Oliver, Wiltfang, Jens, Jäkel, Sarah, Yan, Riqiang, and Nave, Klaus-Armin

Published
2024
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3. Developmental origin of oligodendrocytes determines their function in the adult brain

Author

Foerster, Sarah, Floriddia, Elisa M., van Bruggen, David, Kukanja, Petra, Hervé, Bastien, Cheng, Shangli, Kim, Eosu, Phillips, Benjamin U., Heath, Christopher J., Tripathi, Richa B., Call, Cody, Bartels, Theresa, Ridley, Katherine, Neumann, Björn, López-Cruz, Laura, Crawford, Abbe H., Lynch, Cian J., Serrano, Manuel, Saksida, Lisa, Rowitch, David H., Möbius, Wiebke, Nave, Klaus-Armin, Rasband, Matthew N., Bergles, Dwight E., Kessaris, Nicoletta, Richardson, William D., Bussey, Timothy J., Zhao, Chao, Castelo-Branco, Gonçalo, and Franklin, Robin J. M.

Published
2024
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4. Author Correction: Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Author

Asadollahi, Ebrahim, Trevisiol, Andrea, Saab, Aiman S., Looser, Zoe J., Dibaj, Payam, Ebrahimi, Reyhane, Kusch, Kathrin, Ruhwedel, Torben, Möbius, Wiebke, Jahn, Olaf, Lee, Jun Yup, Don, Anthony S., Khalil, Michelle-Amirah, Hiller, Karsten, Baes, Myriam, Weber, Bruno, Abel, E. Dale, Ballabio, Andrea, Popko, Brian, Kassmann, Celia M., Ehrenreich, Hannelore, Hirrlinger, Johannes, and Nave, Klaus-Armin

Published
2024
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6. Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Author

Schäffner, Erik, Bosch-Queralt, Mar, Edgar, Julia M., Lehning, Maria, Strauß, Judith, Fleischer, Niko, Kungl, Theresa, Wieghofer, Peter, Berghoff, Stefan A., Reinert, Tilo, Krueger, Martin, Morawski, Markus, Möbius, Wiebke, Barrantes-Freer, Alonso, Stieler, Jens, Sun, Ting, Saher, Gesine, Schwab, Markus H., Wrede, Christoph, Frosch, Maximilian, Prinz, Marco, Reich, Daniel S., Flügel, Alexander, Stadelmann, Christine, Fledrich, Robert, Nave, Klaus-Armin, and Stassart, Ruth M.

Published
2023
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7. Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Author

Berghoff, Stefan A., Spieth, Lena, Sun, Ting, Hosang, Leon, Schlaphoff, Lennart, Depp, Constanze, Düking, Tim, Winchenbach, Jan, Neuber, Jonathan, Ewers, David, Scholz, Patricia, van der Meer, Franziska, Cantuti-Castelvetri, Ludovico, Sasmita, Andrew O., Meschkat, Martin, Ruhwedel, Torben, Möbius, Wiebke, Sankowski, Roman, Prinz, Marco, Huitinga, Inge, Sereda, Michael W., Odoardi, Francesca, Ischebeck, Till, Simons, Mikael, Stadelmann-Nessler, Christine, Edgar, Julia M., Nave, Klaus-Armin, and Saher, Gesine

Published
2021
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8. Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+and maintains axonal health

Author

Looser, Zoe J., Faik, Zainab, Ravotto, Luca, Zanker, Henri S., Jung, Ramona B., Werner, Hauke B., Ruhwedel, Torben, Möbius, Wiebke, Bergles, Dwight E., Barros, L. Felipe, Nave, Klaus-Armin, Weber, Bruno, and Saab, Aiman S.

Abstract

The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic coupling is regulated in the white matter, we studied activity-dependent calcium (Ca2+) and metabolite fluxes in the mouse optic nerve. We show that fast axonal spiking triggers Ca2+signaling and glycolysis in OLs. OLs detect axonal activity through increases in extracellular potassium (K+) concentrations and activation of Kir4.1 channels, thereby regulating metabolite supply to axons. Both pharmacological inhibition and OL-specific inactivation of Kir4.1 reduce the activity-induced axonal lactate surge. Mice lacking oligodendroglial Kir4.1 exhibit lower resting lactate levels and altered glucose metabolism in axons. These early deficits in axonal energy metabolism are associated with late-onset axonopathy. Our findings reveal that OLs detect fast axonal spiking through K+signaling, making acute metabolic coupling possible and adjusting the axon–OL metabolic unit to promote axonal health.

Published
2024
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