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Start Over Author "Sven Stringer" Journal nature neuroscience
3 results on '"Sven Stringer"'

1. Author correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia liability

Author

Matthijs D. van der Zee, Albertine J. Oldehinkel, Jue-Sheng Ong, Bart M. L. Baselmans, Dorret I. Boomsma, Jordana T. Bell, Josep Antoni Ramos-Quiroga, Andrew C. Heath, Jaakko Kaprio, Zdenka Pausova, Nicholas G. Martin, Hill F. Ip, Karin J. H. Verweij, Michel G. Nivard, Jaime Derringer, Sarah L. Elson, Marco P. Boks, Marta Ribasés, Tim D. Spector, John R. B. Perry, Pamela A. F. Madden, Catharina A. Hartman, Felix R. Day, Jacqueline M. Vink, Abraham A. Palmer, Susan Branje, Pol A. C. van Lier, Tomáš Paus, Pierre Fontanillas, Wim Meeus, Reedik Mägi, Grant W. Montgomery, Joëlle A. Pasman, Joel Gelernter, Lea K. Davis, Sven Stringer, James MacKillop, Meike Bartels, Nathan A. Gillespie, Danielle Posthuma, Eske M. Derks, Jorien L. Treur, Stuart MacGregor, Harriet de Wit, Zachary Gerring, Sandra Sanchez-Roige, Abdel Abdellaoui, and Marcus R. Munafò

Subjects
0301 basic medicine, medicine.medical_specialty, Schizophrenia (object-oriented programming), Genome-wide association study, 23andMe Research Team, behavioral disciplines and activities, Substance Misuse, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Genetics, medicine, International Cannabis Consortium, 2.1 Biological and endogenous factors, Psychology, Aetiology, Psychiatry, Neurology & Neurosurgery, General Neuroscience, Human Genome, Liability, Causal effect, Neurosciences, Cannabis use, Serious Mental Illness, Brain Disorders, Mental Health, 030104 developmental biology, Schizophrenia, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, Cognitive Sciences, Drug Abuse (NIDA only), Developmental Psychopathology, 030217 neurology & neurosurgery
Abstract

Item does not contain fulltext Several occurrences of the word 'schizophrenia' have been re-worded as 'liability to schizophrenia' or 'schizophrenia risk', including in the title, which should have been "GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability", as well as in Supplementary Figures 1-10 and Supplementary Tables 7-10, to more accurately reflect the findings of the work. 1 p.

Published
2019

2. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Author

Joëlle A. Pasman, Karin J. H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M. L. Baselmans, Jue-Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, Harriet de Wit, Lea K. Davis, James MacKillop, Jaime L. Derringer, Susan J. T. Branje, Catharina A. Hartman, Andre

Published
2018
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3. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Author

Tomáš Paus, Pierre Fontanillas, Pol A. C. van Lier, Lea K. Davis, John R. B. Perry, James MacKillop, Susan Branje, Jue-Sheng Ong, Jordana T. Bell, Sandra Sanchez-Roige, Josep Antoni Ramos-Quiroga, Sven Stringer, Zdenka Pausova, Andrew C. Heath, Joel Gelernter, Bart M. L. Baselmans, Harriet de Wit, Jaime Derringer, Stuart MacGregor, Karin J. H. Verweij, Felix R. Day, Abdel Abdellaoui, Jacqueline M. Vink, Marcus R. Munafò, Sarah L. Elson, Jorien L. Treur, Nicholas G. Martin, Catharina A. Hartman, Albertine J. Oldehinkel, Meike Bartels, Dorret I. Boomsma, Michel G. Nivard, Matthijs D. van der Zee, Marco P. Boks, Grant W. Montgomery, Eske M. Derks, Reedik Mägi, Abraham A. Palmer, Wim Meeus, Jaakko Kaprio, Hill F. Ip, Joëlle A. Pasman, Tim D. Spector, Nathan A. Gillespie, Marta Ribasés, Danielle Posthuma, Pamela A. F. Madden, and Zachary Gerring

Subjects
0301 basic medicine, biology, General Neuroscience, Single-nucleotide polymorphism, Genome-wide association study, Mendelian Randomization Analysis, medicine.disease, biology.organism_classification, Mental health, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Schizophrenia, Mendelian randomization, Trait, medicine, Cannabis, Developmental Psychopathology, Neuroscience, 030217 neurology & neurosurgery, Clinical psychology
Abstract

Contains fulltext : 195179.pdf (Publisher’s version ) (Closed access) Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health–related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health. 10 p.

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