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Your search keyword '"Wu, Ling-gang"' showing total 8 results
Start Over Author "Wu, Ling-gang" Journal nature neuroscience
8 results on '"Wu, Ling-gang"'

7. Ca2+ and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal.

Author

Wu, Xin-Sheng, McNeil, Benjamin D, Xu, Jianhua, Fan, Junmei, Xue, Lei, Melicoff, Ernestina, Adachi, Roberto, Bai, Li, and Wu, Ling-Gang

Subjects
ENDOCYTOSIS
Abstract

A correction to the article "Ca2+. and Calmodulin Initiate All Forms of Endocytosis During Depolarization at a Nerve Terminal" that was published online on July 26, 2009 is presented.

Published
2010
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8. GTP-independent rapid and slow endocytosis at a central synapse.

Author

Xu J, McNeil B, Wu W, Nees D, Bai L, and Wu LG

Subjects
Animals, Animals, Newborn, Brain Stem cytology, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Electric Stimulation methods, Excitatory Postsynaptic Potentials drug effects, Excitatory Postsynaptic Potentials physiology, Excitatory Postsynaptic Potentials radiation effects, Guanosine 5'-O-(3-Thiotriphosphate) pharmacology, Guanosine Triphosphate pharmacology, In Vitro Techniques, Neurons drug effects, Patch-Clamp Techniques methods, Pyridinium Compounds metabolism, Quaternary Ammonium Compounds metabolism, Rats, Rats, Wistar, Synaptotagmin II, Time Factors, Dynamins metabolism, Endocytosis physiology, Guanosine Triphosphate metabolism, Neurons cytology, Synapses physiology
Abstract

Vesicle endocytosis is essential for maintaining synaptic transmission. Its key step, membrane scission, is thought to be mediated by the GTPase dynamin in all forms of endocytosis at synapses. Our findings indicate that GTP-independent and probably dynamin-independent endocytosis co-exist with GTP- and dynamin-dependent endocytosis at the same synaptic nerve terminal, the calyx of Held, in rats. This previously undescribed form of endocytosis could be slow (tens of seconds) and/or rapid (a few seconds), similar to GTP- and dynamin-dependent endocytosis. It was activated during intense stimulation, whereas GTP- and dynamin-dependent endocytosis dominated during mild stimulation. These results establish a new model, in which vesicles are divided into two pools depending on their requirement for GTP and dynamin for retrieval. The GTP- and dynamin-dependent pool has higher priority for release and retrieval, but limited capacity, saturation of which leads to release and thus retrieval of GTP- and dynamin-independent vesicles.

Published
2008
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