Search

The article presents research highlights from the field of T cell memory based on the original research paper "Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow," by K. Tokoyoda et al. that was published in the May 7, 2009 issue of "Immunity." Subjects discussed include antigen-specific memory T cells in mice, immune responses, and the role of interleukin-7 (IL-7) in expressing stromal cells.

The article highlights the recent study on tumor immunotherapy using a myeloablative regimen usage that requires hematopoietic stem cell (HSC) transplantation to rescue mice from fatality. The authors stress that the usage allows the HSCs to drive the expansion and function of transferred tumor-specific CD8+ T cells and results in significantly increased antitumour responses. Significant information relative to these papers is presented.