1. Mechanistic insights from inflammasome structures.
- Author
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Fu J, Schroder K, and Wu H
- Subjects
- Humans, Animals, CARD Signaling Adaptor Proteins metabolism, CARD Signaling Adaptor Proteins immunology, CARD Signaling Adaptor Proteins genetics, Neuronal Apoptosis-Inhibitory Protein metabolism, Neuronal Apoptosis-Inhibitory Protein immunology, Neuronal Apoptosis-Inhibitory Protein genetics, Phosphate-Binding Proteins metabolism, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, NLR Family, Pyrin Domain-Containing 3 Protein immunology, Caspases metabolism, Caspases immunology, Intracellular Signaling Peptides and Proteins metabolism, Intracellular Signaling Peptides and Proteins immunology, Apoptosis Regulatory Proteins metabolism, Apoptosis Regulatory Proteins immunology, NLR Proteins metabolism, Calcium-Binding Proteins metabolism, Calcium-Binding Proteins immunology, Gasdermins, Inflammasomes immunology, Inflammasomes metabolism, Pyroptosis immunology
- Abstract
Inflammasomes are supramolecular complexes that form in the cytosol in response to pathogen-associated and damage-associated stimuli, as well as other danger signals that perturb cellular homoeostasis, resulting in host defence responses in the form of cytokine release and programmed cell death (pyroptosis). Inflammasome activity is closely associated with numerous human disorders, including rare genetic syndromes of autoinflammation, cardiovascular diseases, neurodegeneration and cancer. In recent years, a range of inflammasome components and their functions have been discovered, contributing to our knowledge of the overall machinery. Here, we review the latest advances in inflammasome biology from the perspective of structural and mechanistic studies. We focus on the most well-studied components of the canonical inflammasome - NAIP-NLRC4, NLRP3, NLRP1, CARD8 and caspase-1 - as well as caspase-4, caspase-5 and caspase-11 of the noncanonical inflammasome, and the inflammasome effectors GSDMD and NINJ1. These structural studies reveal important insights into how inflammasomes are assembled and regulated, and how they elicit the release of IL-1 family cytokines and induce membrane rupture in pyroptosis., (© 2024. Springer Nature Limited.)
- Published
- 2024
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