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Your search keyword '"Roychoudhuri, Rahul"' showing total 4 results
Start Over Author "Roychoudhuri, Rahul" Journal nature reviews immunology
4 results on '"Roychoudhuri, Rahul"'

3. Epigenetic control of CD8+T cell differentiation

Author

Henning, Amanda N., Roychoudhuri, Rahul, and Restifo, Nicholas P.

Abstract

Upon stimulation, small numbers of naive CD8+T cells proliferate and differentiate into a variety of memory and effector cell types. CD8+T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8+T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8+T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8+T cell function in individuals with chronic infections and cancer.

Published
2018
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4. Epigenetic control of CD8 + T cell differentiation.

Author

Henning AN, Roychoudhuri R, and Restifo NP

Subjects
Animals, CD8-Positive T-Lymphocytes metabolism, Cellular Reprogramming Techniques methods, Chromatin Assembly and Disassembly genetics, Chromatin Assembly and Disassembly immunology, DNA Methylation immunology, Enhancer Elements, Genetic, Histone Code genetics, Humans, Immunotherapy methods, Models, Genetic, Models, Immunological, Transcription, Genetic, CD8-Positive T-Lymphocytes cytology, CD8-Positive T-Lymphocytes immunology, Cell Differentiation genetics, Cell Differentiation immunology, Epigenesis, Genetic immunology
Abstract

Upon stimulation, small numbers of naive CD8 + T cells proliferate and differentiate into a variety of memory and effector cell types. CD8 + T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8 + T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8 + T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8 + T cell function in individuals with chronic infections and cancer.

Published
2018
Full Text
View/download PDF

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