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1. [The role of glucocorticoids in the development of the phenomenon of bone marrow hematopoiesis stimulation in stress].

Author

Dygaĭ AM, Shakhov VP, Kirienkova EV, Khlusov IA, and Gol'dberg ED

Subjects
Adrenalectomy, Animals, Hyperplasia physiopathology, Male, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Restraint, Physical, T-Lymphocytes physiology, Time Factors, Bone Marrow physiopathology, Glucocorticoids physiology, Hematopoiesis physiology, Stress, Physiological physiopathology
Abstract

In experiments in mice in the model of immobilizing stress the role of glucocorticoids in development of blood marrow stimulation phenomenon has been studied. The glucocorticoids have been found to play a leading role in adaptive reaction of blood system formation in response action of extreme factors, not exerting the myelosuppressing effect. This reaction is characterized by blood marrow hyperplasia development. The glucocorticoids influence the haemopoiesis through the T-lymphocyte system: the homing takes place on the 2-3 day after the beginning of effect of T-cells myelopoiesis regulator, expressing on the surface Lyt-1+, Lyt-2+ antigens.

Published
1990

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