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Evaluation of dental materials biocompatibility presents the first level in assessment of biological acceptance and possible clinical application. The aim of this study was to evaluate biocompatibility of bioceramic materials for root canals obturation by biological response of tissues. Calcium hydroxiapatite (CHA-synthesized in our laboratory) and commercially available blends ARS type I and type III were included in the study. Research was conducted according to the methodology ISO 10993-6: Tests for local effects after implantation - Tests methods for implantation in muscle. Obtained results showed that CHA and ARS Type I from the biocompatibility aspect presents good options as materials for root canal obturation. According to the ISO criteria ARS Type III exhibited poor biological tissue acceptance., Ispitivanje biokompatibilnosti stomatoloških materijala predstavlja prvi korak u ocenjivanju prihvatljivosti materijala i mogućnosti njegove kliničke primene. Cilj rada bio je da se kroz ocenu biološkog odgovora tkiva vrednuje biokompatibilnost materijala za obturaciju kanala korena zuba na bazi biokeramičkih materijala. U ispitivanje su uključeni: eksperimentalni Ca-hidroksiapatitni materijal i komercijalni endodontski biokeramički materijali ARS tip I i tip III. Istraživanje je sprovedeno prema ISO 10993-6: Tests for local effects after implantation - Tests methods for implantation in muscle da bi se ocenio test tkivne reakcije nakon implantacije ispitivanih materijala. Rezultati istraživanja su pokazali da ispitivani Ca-hidroksiapatitni materijal i ARS tip I predstavljaju sa aspekta biokompatibilnosti zadovoljavajuće materijale za obturaciju korensko-kanalnog sistema. Prema postavljenim ISO kriterijumima ATS tip III nije pokazao biološku prihvatljivost na testiranim tkivima.

Evaluation of dental materials biocompatibility presents the first level in assessment of biological acceptance and possible clinical application. The aim of this study was to evaluate biocompatibility of bioceramic materials for root canals obturation by biological response of tissues. Calcium hydroxiapatite (CHA-synthesized in our laboratory) and commercially available blends ARS type I and type III were included in the study. Research was conducted according to the methodology ISO 10993-6: Tests for local effects after implantation - Tests methods for implantation in muscle. Obtained results showed that CHA and ARS Type I from the biocompatibility aspect presents good options as materials for root canal obturation. According to the ISO criteria ARS Type III exhibited poor biological tissue acceptance., Ispitivanje biokompatibilnosti stomatoloških materijala predstavlja prvi korak u ocenjivanju prihvatljivosti materijala i mogućnosti njegove kliničke primene. Cilj rada bio je da se kroz ocenu biološkog odgovora tkiva vrednuje biokompatibilnost materijala za obturaciju kanala korena zuba na bazi biokeramičkih materijala. U ispitivanje su uključeni: eksperimentalni Ca-hidroksiapatitni materijal i komercijalni endodontski biokeramički materijali ARS tip I i tip III. Istraživanje je sprovedeno prema ISO 10993-6: Tests for local effects after implantation - Tests methods for implantation in muscle da bi se ocenio test tkivne reakcije nakon implantacije ispitivanih materijala. Rezultati istraživanja su pokazali da ispitivani Ca-hidroksiapatitni materijal i ARS tip I predstavljaju sa aspekta biokompatibilnosti zadovoljavajuće materijale za obturaciju korensko-kanalnog sistema. Prema postavljenim ISO kriterijumima ATS tip III nije pokazao biološku prihvatljivost na testiranim tkivima.