1. Implications of the microbiome in the development and treatment of pancreatic cancer: Thinking outside of the box by looking inside the gut
- Author
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Qin Yu, Ryan M. Thomas, and Christian Jobin
- Subjects
0301 basic medicine ,Cancer Research ,Pancreatic ductal adenocarcinoma ,Carcinogenesis ,GF, germ free ,Review Article ,medicine.disease_cause ,Bioinformatics ,lcsh:RC254-282 ,SPF, specific pathogen free ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Pancreatic cancer ,medicine ,Humans ,Microbiome ,Pancreas ,Carcinogen ,business.industry ,Microbiota ,Disease Management ,Cancer ,POPF, postoperative pancreatic fistula ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,medicine.disease ,Combined Modality Therapy ,PDAC, Pancreatic ductal adenocarcinoma ,WT, wild-type ,Gastrointestinal Microbiome ,Pancreatic Neoplasms ,Oncobiome ,Natural history ,Cell Transformation, Neoplastic ,Treatment Outcome ,030104 developmental biology ,Bacterial Translocation ,030220 oncology & carcinogenesis ,qPCR, quantitative polymerase chain reaction ,Disease Susceptibility ,business ,Biomarkers ,Carcinoma, Pancreatic Ductal - Abstract
Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death in the United States. As one of the most lethal cancer types, the prognosis for patients diagnosed with pancreatic cancer remains dismal and novel investigations are urgently needed. Evidence for an association of microbes with pancreatic cancer risk, development, treatment response, and post-treatment survivorship is rapidly developing. Herein, we provide an overview on the role of the microbiome as it relates to the natural history of pancreatic cancer, including host immune interactions, alterations in metabolism, direct carcinogenic effect, and its role in treatment response.
- Published
- 2021
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