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Aims: Lack of compliance and unjustified antibiotic prescriptions has resulted in increasing bacterial resistance and is proving as a major challenge in the management of infections. Knowing the commonly isolated uropathogens and their antimicrobial susceptibility is beneficial in planning treatment protocols. Methods: A retrospective review of records of patients with urinary tract infection from January 2012 to December 2016 was conducted at Kathmandu Model Hospital. All patients who were diagnosed as having culture positive urinary tract infection in medical ward of Kathmandu Model Hospital during 5 years period were analyzed for demographic data, prevalence of organism and antibiotic susceptibility patterns. Results: A total of 315 samples were culture positive. The majority of bugs were gram negative E.coli (48.57%) followed by multi-drug resistant E.coli (28.89%). The other major pathogens were E. faecalis (6.03%), S. epidermidis (4.44%), K. pneumoniae (4.13%), respectively. The highest level of sensitivity in first line antibiotics was seen in nitrofurantoin (84.9%), whereas least sensitivity was shown by amoxicillin/clavulanic acid (21%). Similarly, in second line antibiotics, highest sensitivity was seen in tetracycline (100%), imipenem (91.9%) and least to meropenem (49.2%). Ceftazidime is mostly (93.3%) resistant antibiotics among uropathogens. All the third line antibiotics such as polymyxin B, tigecycline and colistin were 100% sensitive to all our isolates. Conclusions: Nitrofurantoin may be an appropriate choice for initial empirical therapy of urinary tract infection. Similarly, the multi-drug resistant E.coli is increasing but it can be tailored if antibiotics are used appropriately on the basis of susceptibility data. [ABSTRACT FROM AUTHOR]

Aims: Laparoscopy has become the most common procedure in recent set-ups. It is now a major diagnostic as well as therapeutic modality for infertility, endometriosis, extrauterine pregnancy and benign ovarian tumors.The aim of the study was to share the experience of gynecological laparoscopic surgeries performed at Kathmandu Model Hospital. Methods: A descriptive study was carried out at Kathmandu Model Hospital from 1st January 2011 to 1st May 2017. All the patients who underwent gynecological laparoscopic surgeries were analyzed for the indication, type of procedure and its complications. Results: Out of 217, majority 24.4 %(n=53) patients were in age group 26-30 years. There were 51.1% (111) cases of ovarian cyst, 12.44%(27) cases of ectopic pregnancy. Eight cases were done with surgeons for cholecystectomy and ovarian cystectomy or hysterectomy. There were 15% (n=32) cases of diagnostic laparoscopy. Total laparoscopic hysterectomy was done in 16% (n=33) cases. Conversion to laparotomy was done in 3%(8) cases. There was one case of vascular injury. Most common immediate post-operative complaint was variable degree of pain, managed with parenteral and oral analgesics. Oral diet started at 4-6th hour post-operatively, and mobilization started after 24 hours. 75% (164) cases had a hospital stay of 2 days and 25%(53) cases stayed for 3 days. Conclusions: Laparoscopic surgery at our hospital has been well demonstrated in terms of reducing postoperative pain and decreasing postoperative morbidity, short hospital stay, and less postoperative recovery time. However, adequate advanced training and devices are needed to perform skillful laparoscopic surgeries. [ABSTRACT FROM AUTHOR]

Aims: The study was done to analyze the epidemiology, diagnosis and treatment aspect of patients with ectopic pregnancy at Kathmandu Model Hospital. Methods: This was a retrospective study of patients with ectopic pregnancy who received treatment at Kathmandu Model Hospital from January 2008 to September 2015. Data were analyzed from patient records and discharge summary. Delivery number was obtained from maternity record. Results: There were 61 cases of ectopic pregnancy with the hospital incidence of 1.46%. Highest number of patients 20 (32.79%) were in the age range of 28-32 years. Most of the patients were nullipara 22 (36.06%) or with parity two 20 (32.79%). Some risk factors were found in 29 (47.54%) cases. The commonest risk factor was pelvic inflammatory disease in 12 (19.67%). All presented with pain abdomen, 48 (78.68%) had per vaginal bleeding, 17 (27.87%) presented in shock. Cervical excitation was present in 38 (62.29%). Urine for pregnancy test was positive in all and 37 (60.66%) had ultrasonography. Ten (16.39%) patients underwent emergency laparoscopic surgery and 40 (65.57%) had emergency laparotomy. Salpingectomy was required in 53 (86.89%) cases. The average hospital stay was 5 days. Conclusions: The study showed that ectopic pregnancy could occur at any reproductive age without obvious risk factors. Although not all patients gave history of amenorrhoea, pain abdomen was present in all. [ABSTRACT FROM AUTHOR]

Vaginal atresia is one of the common congenital anomalies of the female lower genital tract due to incomplete canalization of Mullerian ducts. It mostly presents as primary amenorrhoea with attacks of severe lower abdominal pain at monthly interval in presence of appropriate Tanner staging secondary sex characteristics. It is diagnosed by clinical presentation, examination and imaging, usually ultrasound scan and magnetic resonance imaging. There are conservative non-surgical as well as surgical methods to correct it. A 13 years pubertal girl presented at Kathmandu Model Hospital with complaints of cyclic severe lower abdominal pain since one year with presence of appropriate secondary sexual characteristics. Ultrasound showed features suggestive of hematometra. She underwent drainage of hematocolpos with neo-vaginoplasty followed by intravaginal mould placement. She also underwent dilatation of neovagina thrice under IVA to maintain the vaginal length and function. We present here a case of isolated vaginal atresia, who underwent Mc Indoe Vaginoplasty followed by serial dilatation. [ABSTRACT FROM AUTHOR]

The ectopic implantation is implantation of fertilized ovum outside the uterine cavity, ampulla of fallopian tube being the most common site. A cornual or interstitial pregnancy is an ectopic pregnancy that develops in the interstitial portion of the fallopian tube which is one of the most hazardous type of ectopic gestation. Treatment depends on the week of gestation at the time of diagnosis, level of serum β HCG, findings of ultrasonography, hemodynamic stability of the patient and the choice of future fertility. In this case report, we present a case which was previously misdiagnosed as a case of missed abortion at 8 weeks of gestation by transabdominal ultrasound and patient underwent medical abortion with mefipristione and misoprostolandafter 1 month presented with pain abdomen and was confirmed as extrauterine pregnancy by transabdominal ultrasound followed by surgical management. [ABSTRACT FROM AUTHOR]

Ovarian cysts are common findings in females of reproductive age. Mostly, they are non neoplastic and hormonally dependent as follicular, simple, and corpus luteum cysts. Ovarian cysts are rarely grown to reach huge size without raising any symptoms. Most of the cases that have huge cysts present with pressure symptoms over the genitourinary system leading to urinary complaints or the respiratory system lead to respiratory embarrassment. Dermoid cysts account for 10-20% of all ovarian neoplasms. They are common in young women, especially at the age of 30 years.In most of cases, they are asymptomatic and can be discovered accidentally on clinical examination or ultrasonographic scan. They are usually indolent tumors with very slow rate of growth about 1.8 mm per year. Giant dermoid cysts have been infrequently reported in the literature. This is a case report of huge dermoid cyst weighing 25 kgs in a 42-year old perimenopausal lady that remained relatively asymptomatic. She underwent Laparotomy with ovarian cystectomy. [ABSTRACT FROM AUTHOR]

Aims: This study was done to know the demographic profile of women undergoing second trimester abortion at Kathmandu Model Hospital. The aim was to see the success rate of combination of mifeprostone and misoprostol for the medical induction and misoprostol alone for the cervical dilation in case of surgical evacuation. Methods: A retrospective study was done by looking at the profiles of 540 clients on whom second trimester abortion was performed during the period of October 2010 to October 2014. Twenty-nine women underwent dilatation and evacuation (D&E) with misoprostol cervical priming, and 510 underwent medical induction with mifeprostone and misoprostol whereas one client absconded. Furthermore, the reasons for seeking second trimester abortion were also investigated. Results: It can be seen that the age of women undergoing second trimester abortion at Kathmandu Model Hospital was greatest (33.33%) for the age group of 26-30 years. Most women were illiterate (31.67%) and a majority of the women were housewives (89.81%). A greater proportion of the women had never undergone abortion. Mental cause appeared to be the major reason for abortion constituting 82.04%. Success was 90.58%, expulsion with total five doses of misoprostol. The median induction to abortion time was 4-7 hours. The expulsion hours increased as the gestational age increased. The median number of dose of misoprostol required was two for medical induction and three for surgical abortion. Conclusions: Mifeprostone and misoprostol, as combination was a good method for the medical induction of second trimester pregnancy and misoprostol alone for the cervical preparation in surgical evacuation was promising. [ABSTRACT FROM AUTHOR]

Twenty-five years have passed since the global community agreed in Nairobi to address the high maternal mortality by implementing the Safe Motherhood Initiative. However, every year around 22 million women seek unsafe abortion in developing countries. Globally, the unsafe abortion accounts for 13% maternal deaths. Out of the total aborted women, around five million women were admitted to hospitals as a result of unsafe abortion. Similarly, more than three million women suffer from severe complications from unsafe abortion every year. In 2002, responding to the public voices and high attribution of unsafe abortion on maternal mortality, Nepal granted legal access to safe abortion introducing safe abortion act. Women can seek abortion up to 12 weeks of gestation for any indication. However, sex selective pregnancy termination is prohibited in Nepal. This study aimed to assess the results of various studies on abortion practices in Nepal. Literature published in PubMed, Lancet, Medline, WHO and Google Scholar web pages from 1990 to 2014 were used to prepare this paper. From 2004 to 2014, more than half a million women sought safe abortion care in Nepal. Despite the considerable progress, unsafe abortion is still a major issue in Nepal as it has been estimated that it constitutes half of all abortions undertaken every year. Published literature further showed that still an unmet need of safe abortion services exists in Nepal. However, the overall awareness of legal abortion was found to be high among Nepalese women. We found negative attitude of most people towards women who sought abortion care. Similarly, a large number of unmarried women were found at risk for seeking abortion care due to socio-cultural norms, values and stigmas in Nepal. [ABSTRACT FROM AUTHOR]

Aims: This study aimed to find association of marital rape with gynecological problems and socio-demographic factors, which helped to explore possible underlying issues and to provide appropriate services to the women. Methods: A cross sectional quantitative study was carried out. Three hundred sixty two married women who came to the health care centres of Public Health Concern Trust (phect-NEPAL) for any kind of health services were enrolled for the study. Data was collected through semi structured interview questionnaire. Bivariate analysis and multiple binary logistic regression analysis were applied to identify the factors associated gynecological problems and marital rape. Results: The study revealed that out of 362 women, 194 (53.6%) experienced marital rape either everyday or sometime. Out of 362 women, 48.6% (194) were suffered from gynecological problems. Women who had undergone rape had 2.32 times more likely to experience gynecological problems than those who did not (OR 2.3, 95% CI 1.52-3.55). Marital rape was found statistical significantly associated (p-value < 0.05) with economic condition, interspousal communication, and difference among interspousal sexual desire, husband's violent nature, husband's dominant attitude, husband's alcohol intake and gynecological problem. Conclusions: Marital rape was associated with existence of gynecological problem in the wife. Therefore, women with gynecological problems should also be explored for marital rape and counseling and service should be provided. [ABSTRACT FROM AUTHOR]

Patients diagnosed with a life threatening condition like cancer suffer physically, socially and mentally. Their quality of life can be improved by effective communication and good symptom control even when the disease is incurable. Pain is the most common symptom and can be controlled by optimal use of analgesics especially oral morphine if severe. Psychosocial issues like depression and anxiety can be minimized by counseling and use of medicines. Death is more painful than birth but can be minimized by understanding the reality and by honest sharing which will help to minimize unnecessary sufferings. Palliative care is the care of these patients and their family members to make their life comfortable. Modern palliative care has developed around the world since the 1960s and in Nepal, since the beginning of 21st century. Much remains to be done before palliative care can be an integrated part of health care in Nepal. In this context gynaecologist having knowledge and skills in palliative care, have an important role in improving the quality of life of patients with life threatening conditions and their family members. [ABSTRACT FROM AUTHOR]

Aims: This study was done to find out the incidence and outcome of caesarean sections done at Kirtipur Hospital. Methods: This was a retrospective study conducted from 1st January 2009 to 31st December 2013. Case files of 660 patients who underwent caesarean section for various indications were analyzed for incidence, indication of caesarean section, booking status, parity, and maternal and fetal outcomes. Results: Out of 1295 deliveries, 50.9% (n=660) had caesarean section. Most of the caesarean section was done for fetal distress (40.2%; n=265) and on account of previous history of caesarean section (13.5%; n=89). Majority of caesarean section (44.4%, n=293) was done in age group of 25-29 years. Among them, 65.9% (n=435) were nulliparous. There were 35.3% (n=563) booked cases. Emergency caesarean sections were performed in 62.4% (n=412) cases. Maternal morbidity was less (7.2%, n=48). Conclusions: The study showed high rate of caesarean section. The most common indication was fetal distress. Post-operative complications and fetal outcome were within acceptable range. [ABSTRACT FROM AUTHOR]

Aim: The study was done to review the demography of urogenital fistulae including obstetric fistula (OF) and its surgical outcome in the early phase of fistula surgery and to create awareness about OF. Methods: This was a retrospective study of 47 patients who underwent fistula surgery during the period of January 2012 to May 2014 in Kathmandu Model Hospital, Helping Hand Community Hospital, Camp in Mid-wetern Regional Hospital Surkhet and Hamlin Hospital, Ethiopia. The primary outcome was in terms of urinary continence after 14 days of repair. Results: In the study 70% (n=33) of fistula were due to obstructed labour and 30% (n=14) were due to hysterectomy for gynecological indications. Ninety six percent (n=45) had successful closure of fistula. Seventy seven percent (n=36) were continent after surgery, and 17% (n=8) had some stress incontinence. Conclusions: The study showed obstructed labour was the major cause of OF, however iatrogenic fistula was also becoming common. The success of repair depended on the type, site, size of fistula and urethral length. Majority of our cases had successful closure of fistula with some degree of stress in some patients. [ABSTRACT FROM AUTHOR]

Twenty-five years have passed since the global community agreed in Nairobi to address the high maternal mortality by implementing the Safe Motherhood Initiative. However, every year nearly three million women die due to pregnancy related causes. This tragedy is avoidable if women have timely access to required emergency obstetric care. Emergency obstetric care refers to life-saving services for maternal and neonatal complications provided by skilled health workers. Since the beginning of the 1980's, several efforts have been intensified to improve maternal and child health status and reducing the high morbidity and mortality. There was built on a worldwide consensus to provide improved maternal and child health care for addressing the high morbidity and mortality. All participant countries agreed to integrate emergency obstetric care services in their national health care system. Emergency obstetric care is one of the strategies for reducing the maternal mortality as pregnancy related complications are unpredictable. However, many women in developing countries do not have access to essential health care services including emergency obstetric care. Basic emergency obstetric care by skilled birth attendants or timely referral for further comprehensive emergency obstetric care can reduce maternal deaths and disabilities significantly. This paper is based on the results published in PubMed, Medline, Lancet, WHO and Google Scholar web pages from 1990 to 2013. [ABSTRACT FROM AUTHOR]

Aims: This study was done to find out age wise distribution pattern, cellular abnormality and adequacy of Pap smears. Methods: A retrospective study of 4800 Pap smears based on laboratory database was done from 2008 to 2011 at Helping Hands Community Hospital in Kathmandu, Nepal. Graphical method was used for normality test and frequency analysis was done using SPSS 16. Results: Out of 4794 analysable data 4.21% had abnormal cytology, all high-grade lesions were in 51-65 age group and 0.06% were detected as carcinoma. Age group of 30-65 years covers four-fifth of the samples (3811, 79.4%) and 85.6% of abnormal cytology (173 out of 202) with maximum samples (3313, 69%) at 30-50 years and 55.44% of abnormal cytology. Only 5.4% of samples categorized as inadequate by Bethesda reporting system. Age wise distribution of samples produced near normal Gaussian curve. Results: Out of 4794 analysable data 4.21% had abnormal cytology, all high-grade lesions were in 51-65 age group and 0.06% were detected as carcinoma. Age group of 30-65 years covers four-fifth of the samples (3811, 79.4%) and 85.6% of abnormal cytology (173 out of 202) with maximum samples (3313, 69%) at 30-50 years and 55.44% of abnormal cytology. Only 5.4% of samples categorized as inadequate by Bethesda reporting system. Age wise distribution of samples produced near normal Gaussian curve. [ABSTRACT FROM AUTHOR]

Obstetric fistulae is the most tragic of preventable childbirth complications in the developing world, as affected women are often abandoned by their husbands and family, and forced to live in shame. They occur almost entirely in the developing world and their incidence is poorly studied. Their management requires accurate diagnosis, sufficient pre-operative workup, fine surgery following standard surgical repair steps and principles by skilled surgeons, specialised post-op care, and follow-up. As obstetric fistula is a serious preventable public health issue in developing countries, national and international organizations should launch a campaign to end fistula by increasing the resources and skilled staff available locally to treat obstetric fistula for improving the lives of women currently living with this condition. Moreover, effective preventive strategies for obstetric fistula such as better education to women and provision of improved obstetric care and searching for the best approaches to both prevention and treatment should be the priority. The materials published in PubMed, Lancet, Medline, WHO and Google Scholar web pages from 1990 to 2013 have been utilized to prepare this paper. [ABSTRACT FROM AUTHOR]

Achieving Millennium Development Goal (MDG) 5 still remains a challenge to Nepal. It is necessary to collect reliable evidence on maternal health for tackling MDG 5 with limited resources. A continuous assessment of maternal mortality is required to assure the progress towards the MDG 5. This study aims to assess the results of the different studies on maternal mortality in Nepal. The results published in PubMed, Lancet, Medline, WHO and Google Scholar web pages from 1990 to 2012 have been utilized to prepare this paper. In spite of the low proportion of births attended by skilled persons and institutional delivery, the maternal mortality ratio (MMR) in Nepal has declined drastically between the years 1990 and 2011, from 850 to 229 deaths per 100,000 live births. In recent years, Nepal is also reaching progress in different maternal health indicators such as mothers receiving antenatal care from skilled providers (60%- up from 24% in 1996). More than one-third births in the past five years have been assisted by skilled care providers. Nearly, 45% of women received postnatal care for their last birth in the first two days after delivery, 38% of women is aware of abortion which has been legalized since 2003. Though maternal health is a priority agenda of Nepal among the policy makers and the country is likely to achieve Millennium Development Goal 5 by the year 2015, there is still a wide gap between policies and charted targets, and the real accessibility and availability of the quality health services. [ABSTRACT FROM AUTHOR]

Transverse vaginal septum is a congenital anomaly of the female genital outflow tract. It mostly remains unrecognized till adolescence and manifests as primary amenorrhoea with cyclic lower abdominal pain in background of appropriate Tanner staging secondary sex characteristics. Diagnosis is done by clinical examination and imaging, usually Magnetic Resonance Imaging. Early surgical management by vaginal or abdominal approaches improves the outcome.A16years adolescent with appropriate Tanner staging secondary sex characteristics presented to gynecology (OPD) of Kathmandu Model Hospital with complaints of primary amenorrhoea and palpable abdominal mass of 24 weeks size with cyclic lower abdominal pain. Ultrasound showed features suggestive of hematometra. Under spinal anaesthesia, drainage and excision of the transverse vaginal septum was done followed by placement of vaginal mould post-operatively. We present here a case of primary amenorrhoea with pyometra secondary to transverse vaginal septum. [ABSTRACT FROM AUTHOR]

Aims: This study was done to find out the spinal anaesthesia failure rate necessitating the conversion to general anaesthesia and use of intraoperative supplemental analgesia. Methods: This was a retrospective study undertaken in Kirtipur hospital in 660 patients. Spinal anaesthesia (0.5% heavy bupivacaine 2.2 ml) was given to women who had undergone elective or emergency caesarean section from January 2009 to December 2013. Results: In this study spinal anaesthesia failure rate was 1.66% (n=11/660). Among them complete failed spinal anaesthesia rate was 0.75% (n=5/660) requiring conversion to general anaesthesia. Intraoperative supplemental analgesic and sedation like pethidine, ketamine or midazolam was required in 0.90% (n=6/660). Conclusions: The failure rate of spinal anaesthesia given for caesarean section was low (1.66%) and it was within the acceptable range. [ABSTRACT FROM AUTHOR]

Abdominal sacro-colpopexy (ASC) is a commonly performed procedure for the surgical treatment of pelvic organ prolapse (POP). Surgeons favor this technique because of its well-established success rates ranging from 78-100% and durability, which is attributed to reinforcement of native tissues with a graft. Despite recognition of the risk of erosion, synthetic grafts have been preferred over autologous grafts for abdominal sacro-colpopexy because they are durable, avoid the morbidity and operative time of harvesting fascia, are readily available and are relatively inexpensive. Ideally, these benefits should outweigh the possibility of erosion, which is a unique complication of using a graft. We present here a unique case of mesh erosion into bowel after sacro-colpopexy who presented with sigmoido-vaginal fistula. [ABSTRACT FROM AUTHOR]