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Aim: Patients with chronic kidney disease (CKD) are more susceptible to endothelial dysfunction and cardiovascular disease (CV). Remote ischemic preconditioning (rIPC) has been proven efficient in improving endothelial function and lowering the risk of CV. However, the safety and effect of rIPC on endothelial function in patients with CKD have not been effectively assessed. Methods: 45 patients with CKD (average estimated glomerular filtration rate: 48.4 mL/min/1.73 m2) were randomly allocated to either 7‐day daily upper‐arm rIPC (4 × 5 min 200 mmHg, interspaced by 5‐min reperfusion) or control (4 × 5 min 60 mmHg, interspaced by 5‐min reperfusion). Vascular endothelial function was assessed by natural log–transformed reactive hyperemia index (LnRHI) before and after a 7‐day intervention. Arterial elasticity was assessed by augmentation index (AI). Results: The results showed that LnRHI could be improved by rIPC treatment (Pre = 0.57 ± 0.04 vs. Post = 0.67 ± 0.04, p =.001) with no changes relative to control (Pre = 0.68 ± 0.06 vs. Post = 0.64 ± 0.05, p =.470). Compared with the control group, the improvement of LnRHI was greater after rIPC treatment (rIPC vs. Control: 0.10 ± 0.03 vs. −0.04 ± 0.06, between‐group mean difference, −0.15 [95% CI, −0.27 to −0.02], p =.027), while there was no significant difference in the change of AI@75 bpm (p =.312) between the two groups. Conclusion: RIPC is safe and well tolerated in patients with CKD. This pilot study suggests that rIPC seems to have the potential therapeutic effect to improve endothelial function. Of note, further larger trials are still warranted to confirm the efficacy of rIPC in improving endothelial function in CKD patients. [ABSTRACT FROM AUTHOR]