5 results on '"Alfons Segarra"'
Search Results
2. Relationship between immunoglobulin A1 lectin-binding specificities, mesangial C4d deposits and clinical phenotypes in immunoglobulin A nephropathy
- Author
-
Elias Jatem, Marisa Martin, Alfons Segarra Medrano, Jorge Gonzalez, Andrea Muijsemberg, Alicia Garcia-Carrasco, Cristina Martínez, Jonathan Barratt, Laura Colàs-Campàs, and David Wimbury
- Subjects
IgA binding ,Glycan ,Mannose ,chemical and pharmacologic phenomena ,Nephropathy ,chemistry.chemical_compound ,fluids and secretions ,stomatognathic system ,Lectins ,Complement C4b ,medicine ,Humans ,Transplantation ,Proteinuria ,biology ,business.industry ,Glomerulonephritis, IGA ,medicine.disease ,Molecular biology ,Peptide Fragments ,Immunoglobulin A ,Complement system ,Cross-Sectional Studies ,Phenotype ,chemistry ,Nephrology ,Lectin pathway ,biology.protein ,medicine.symptom ,business ,Neuraminidase - Abstract
Background The reason why mesangial C4d deposits are detected in only certain biopsies of immunoglobulin A nephropathy (IGAN) remains unclear. We analyse the association between IgA glycosylation patterns, mesangial C4 deposition and clinical phenotypes in IgAN. Methods This cross-sectional study included 145 patients with idiopathic IgAN. We measured the serum levels of three different IgA1 lectin-binding specificities using enzyme-linked immunosorbent assays with and without treatment with neuraminidase and we analysed the relationship between these glycoforms, C4d mesangial deposits and clinical phenotypes. Results C4d-positive versus Cd4-negative patients had higher proteinuria [median 3.1 g/g (0.9–4.2) versus 1.8 (1–2.2); P = 0.000], haematuria [223 cells/µL (32–278) versus 99 (25–186); P = 0.000] and higher levels of IgA binding to neuraminidase untreated Helix aspersa (HA IgA1 neu−; 150.6 ± 52 U versus 96.2 ± 64.1; P = 0.000), neuraminidase untreated Helix pomatia (HPA IgA1 neu−; 0.34 ± 0.15 U versus 0.27 ± 0.13; P = 0.04), Triticum vulgaris (TV IgA1; 85.1 ± 31.7 U versus 42.2 ± 26.9; P = 0.000) and Canavalia ensiformis (ConA IgA1; 32.5 ± 18 U versus 16.7 ± 9.38; P = 0.000). The levels of HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 were all associated with the mesangial deposition of C4d, extracapillary proliferation and acute kidney injury. In receiver operating characteristics curves, HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 significantly discriminated between C4d-positive ad C4d-negative biopsies. In logistics models, TV IgA1 and ConA IgA1 were the only independent predictors of mesangial C4d deposits. Conclusions In IgAN, the severity of the disease is associated with the level of IgA exposing N-acetyl-d-galactosamine, N-acetyl-d-glucosamine or mannose, whereas C4d deposits are only associated with elevated levels of IgA1 glycoforms exhibiting glycan residues with specificity for mannose and N-acetyl-d-glucosamine binding lectins. more...
- Published
- 2020
- Full Text
- View/download PDF
Catalog
3. Relationship between immunoglobulin A1 lectin-binding specificities, mesangial C4d deposits and clinical phenotypes in immunoglobulin A nephropathy.
- Author
-
Medrano, Alfons Segarra, Muijsemberg, Andrea, Wimbury, David, Martin, Marisa, Jatem, Elias, González, Jorge, Colás-Campás, Laura, García-Carrasco, Alicia, Martínez, Cristina, and Barratt, Jonathan
- Subjects
- *
IGA glomerulonephritis , *LECTINS , *RECEIVER operating characteristic curves , *ENZYME-linked immunosorbent assay , *ACUTE kidney failure , *PHENOTYPES , *NEURAMINIDASE - Abstract
Background The reason why mesangial C4d deposits are detected in only certain biopsies of immunoglobulin A nephropathy (IGAN) remains unclear. We analyse the association between IgA glycosylation patterns, mesangial C4 deposition and clinical phenotypes in IgAN. Methods This cross-sectional study included 145 patients with idiopathic IgAN. We measured the serum levels of three different IgA1 lectin-binding specificities using enzyme-linked immunosorbent assays with and without treatment with neuraminidase and we analysed the relationship between these glycoforms, C4d mesangial deposits and clinical phenotypes. Results C4d-positive versus Cd4-negative patients had higher proteinuria [median 3.1 g/g (0.9–4.2) versus 1.8 (1–2.2); P = 0.000], haematuria [223 cells/µL (32–278) versus 99 (25–186); P = 0.000] and higher levels of IgA binding to neuraminidase untreated Helix aspersa (HA IgA1 neu−; 150.6 ± 52 U versus 96.2 ± 64.1; P = 0.000), neuraminidase untreated Helix pomatia (HPA IgA1 neu−; 0.34 ± 0.15 U versus 0.27 ± 0.13; P = 0.04), Triticum vulgaris (TV IgA1; 85.1 ± 31.7 U versus 42.2 ± 26.9; P = 0.000) and Canavalia ensiformis (ConA IgA1; 32.5 ± 18 U versus 16.7 ± 9.38; P = 0.000). The levels of HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 were all associated with the mesangial deposition of C4d, extracapillary proliferation and acute kidney injury. In receiver operating characteristics curves, HA IgA1 neu−, HPA IgA1 neu−, TV IgA1 and ConA IgA1 significantly discriminated between C4d-positive ad C4d-negative biopsies. In logistics models, TV IgA1 and ConA IgA1 were the only independent predictors of mesangial C4d deposits. Conclusions In IgAN, the severity of the disease is associated with the level of IgA exposing N -acetyl- d -galactosamine, N -acetyl- d -glucosamine or mannose, whereas C4d deposits are only associated with elevated levels of IgA1 glycoforms exhibiting glycan residues with specificity for mannose and N -acetyl- d -glucosamine binding lectins. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF
4. Clinical nephrology - IgA nephropathy, lupus nephritis, vasculitis
- Author
-
Piero Stratta, David Jayne, Fabio Sallustio, Alina Casian, Jingyuan Xie, Cristiane B. Dias, Serena Simeone, John Feehally, Hong Ren, Patrícia Cotovio, Derya Özmen, Byung Yoon Yang, Harin Rhee, Xiangmei Chen, Rosanna Coppo, Rachel B Jones, Jean Pierre Fauvel, Derya Guler, Hee Yeon Jung, Grazia Serino, Isao Ohsawa, George Efstratiadis, Claire Kennedy, Afroditi Pantzaki, Claudia Yuste, I. De Simone, Jadwiga Małdyk, Michael R. Clarkson, G. B. Visciano, Wenhu Liu, Krzysztof Kiryluk, Shubha Bellur, Beata Bienias, Jing Xu, Carlos Botelho, Özlem Yilmaz, Yuansheng Xie, François Berthoux, Rui Toledo Barros, Ali G. Gharavi, Emilie Kalbacher, Manuel Praga, Wenge Li, Shuwei Duan, Christos Bantis, Chunhua Zhou, Soo Bong Lee, Ligia C. Battaini, F. Ferrario, Noshaba Naz, George Toulkeridis, Cristina Silva, Stratis Kasimatis, Ying Zheng, Kyung Hoon Kim, Owen Kwon, Dóra Bajcsi, Weiming Wang, Viktoria Woronik, Pedro Maia, György Ábrahám, Kálmán Polner, Denis Fouque, Katarzyna Gadomska-Prokop, Yoshio Shimizu, Chan-Duck Kim, Federico Mecacci, Brigitte MacGregor, Sun-Hee Park, Dong Won Lee, Karina Lopes, Shanmai Guo, Rona M Smith, Aikaterini Papagianni, Leticia Jorge, Xiaoxia Pan, Guangyan Cai, Roman Stankiewicz, Il Young Kim, Yavuz Doǧan, Cristina Izzo, Ian Roberts, Hesham Mohey, A. Pani, Zhi-Qiang Huang, Jan Novak, Benedek Ronaszeki, Anindya Banerjee, Mark Canney, Haner Direskeneli, Lide Lun, Michel Ducher, Hakki Arikan, G. Fogazzi, Rui Toledo-Barros, Francesco Paolo Schena, Norella C T Kong, Armando Carreira, Denise Malheiro, Cristina Jironda, Yasuhiko Tomino, Anna Wasilewska, Xuemei Li, Francois Combarnous, Yong-Xi Chen, Myrthes Toledo-Barros, Halim Abdul Gafor, Philip H. Bredin, Ekaterina S Stolyarevich, Bruce A. Julian, Elena Romoli, Eun Young Seong, Jianrong Zhang, Salih Kavukçu, Ryszard Grenda, V. Terraneo, Maria Roszkowska-Blaim, Jie Wu, Koshi Yamada, Maria Júlia Correia Lima Nepomuceno Araújo, Colin Reily, Péter Légrády, Hitoshi Suzuki, Małgorzata Mizerska-Wasiak, Peter A. Merkel, Ihm Soo Kwak, Arzu Velioglu, Serdar Nalcaci, Nan Chen, Elisa Lazzarich, Yusuke Suzuki, Ga Young Park, Giorgio Mello, C. Sarcina, Shamsul Azhar Shah, Elena Zakharova, Sabah Mohamed Alharazy, Roberta Camilla, Satoshi Horikoshi, Marlyn Mohammad, Jin Lee, Yaping Wang, Cristiane Bitencourt Dias, Mehmet Koc, Lectícia Barbosa Jorge, Gurdal Birdal, Mário Campos, Terence Cook, Francisco Ferrer, C. Pozzi, F. Rastelli, Maria Skoularopoulou, Calogero Cirami, Francesco Pesce, Alfons Segarra, Agnieszka Rybi-Szumińska, Pingyan Shen, Luca Vergano, Cetin Ozener, Mrityunjay Hiremath, Jang-Hee Cho, Zsolt Balla, Roberta Fenoglio, Shuwen Liu, Maria Stangou, Hiyori Suzuki, Mamiko Shimamoto, Yeşim Öztürk, Serhan Tuglular, Elisabetta Radin, Małgorzata Zajaczkowska, Liam Plant, Enrico Eugenio Minetti, Rivera F, Marco Quaglia, Zhao-Hui Wang, Stéphan Troyanov, Arbaiyah Bain, Daniel C. Cattran, Yaser Shah, Ya Li, Blandine Laurent, Christophe Mariat, Maria Guedes Marques, Wen Zhang, Béla Iványi, Sharon Cox, Alper Soylu, Min Ji Shin, Laura Morando, Yong-Lim Kim, Xiaoyan Zhang, Seiji Nagamachi, Vivian L. Onusic, Michelle Lewin, Zoltán Rakonczay, Andrea Airoldi, Agnieszka Firszt-Adamczyk, Pamela Gallo, Zina Moldoveanu, Ágnes Haris, Milan Raska, Ji-Young Choi, and Sandor Sonkodi more...
- Subjects
Transplantation ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine ,Lupus nephritis ,Clinical nephrology ,medicine.disease ,Vasculitis ,business ,Dermatology ,Nephropathy - Published
- 2013
- Full Text
- View/download PDF
5. Combined therapy of tacrolimus and corticosteroids in cyclosporin‐resistant or ‐dependent idiopathic focal glomerulosclerosis: a preliminary uncontrolled study with prospective follow‐up†
- Author
-
Leonor Pou, Antonia Arbós, Teresa Quiles, Josefa Vila, Luis Piera, Joaquim Majo, and Alfons Segarra
- Subjects
Adult ,medicine.medical_specialty ,Drug Resistance ,Kidney ,Gastroenterology ,Tacrolimus ,Adrenal Cortex Hormones ,Prednisone ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Transplantation ,Proteinuria ,Glomerulosclerosis, Focal Segmental ,business.industry ,Glomerulosclerosis ,Middle Aged ,medicine.disease ,Surgery ,Nephrology ,Cyclosporine ,Trough level ,Drug Therapy, Combination ,medicine.symptom ,business ,Nephrotic syndrome ,Immunosuppressive Agents ,Follow-Up Studies ,medicine.drug ,Kidney disease - Abstract
Background. Cyclosporin has improved the outcome for steroid-resistant patients with focal glomerulosclerosis, but there is a proportion of patients that are either cyclosporin-resistant or suffer relapses, needing long-term therapy to sustain the remission. In these cases, preliminary reports suggest that tacrolimus could be an alternative therapy, but to date the evidence is limited to small series of patients with no long-term follow-up. Methods. In this study we analysed the efficacy and safety of a combined therapy of tacrolimus and steroids in 25 patients (mean serum creatinines 1.24"0.49 mgudl; mean proteinurias 10.2"9.5 guday; mean serum albumins2.4"0.58 gudl) with idiopathic primary focal glomerulosclerosis and proven resistance to or dependence on cyclosporin A. Results. After a 6 months trial of tacrolimus and steroids, proteinuria decreased in 17 patients (68%) (complete remission in 10 patients (40%), partial remission in two patients (8%) and a moderate reduction in proteinuria to levels - 3g uday was seen in five additional patients (20%)). The only predictor of response to tacrolimus was a previous response to cyclosporin and prednisone, either as a complete or partial remission (remission rate 75% vs 15.3; Ps0.036). Mean time to remission was 112"24 days. After tacrolimus discontinuation, 13u17 patients (76%) relapsed and were treated with a second trial of tacrolimus for 1 year, achieving complete remission in five patients (38.4%), partial remission in four patients (30.7%) and reduction of proteinuria - 3g uday in four patients (30.7%). After 2 years of follow-up, 12 patients (48%) were on sustained remission. The main side effect was acute reversible nephrotoxicity (40%). Predictors of renal toxicity were age (Ps 0.037), baseline creatinine (Ps 0.046) and tacrolimus trough level (Ps0.001). Conclusions. We conclude that combined therapy of tacrolimus and steroids induce sustained remission of proteinuria in a significant number of patients with idiopathic focal glomerulosclerosis whose disease was not controlled by the standard therapy of steroids and cyclosporin A. more...
- Published
- 2002
- Full Text
- View/download PDF
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.