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Your search keyword '"Egfr decline"' showing total 9 results
Start Over Descriptor "Egfr decline" Journal nephrology dialysis transplantation
9 results on '"Egfr decline"'

2. Association between vascular access creation and deceleration of estimated glomerular filtration rate decline in late-stage chronic kidney disease patients transitioning to end-stage renal disease.

Author

Keiichi Sumida, Molnar, Miklos Z., Potukuchi, Praveen K., Thomas, Fridtjof, Jun Ling Lu, Ravel, Vanessa A., Soohoo, Melissa, Rhee, Connie M., Streja, Elani, Yamagata, Kunihiro, Kalantar-Zadeh, Kamyar, and Kovesdy, Csaba P.

Subjects
*ARTERIOVENOUS fistula, *GLOMERULAR filtration rate, *CHRONIC kidney failure, *HEMODIALYSIS, *KIDNEY diseases
Abstract

Background. Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this is attributable to the physiological benefits of a mature access on systemic circulation versus confounding factors. Methods. We examined a nationwide cohort of 3026 US veterans with advanced chronic kidney disease (CKD) transitioning to dialysis between 2007 and 2011 who had a pre-dialysis AVF/ AVG and had at least three outpatient eGFR measurements both before and after AVF/AVG creation. Slopes of eGFR were estimated using mixed-effects models adjusted for fixed and time-dependent confounders, and compared separately for the pre- and post-AVF/AVG period overall and in patients stratified by AVF/AVG maturation. In all, 3514 patients without AVF/AVG who started dialysis with a catheter served as comparators, using an arbitrary 6-month index date before dialysis initiation to assess change in eGFR slopes. Results. Of the 3026 patients with AVF/AVG (mean age 67 years, 98% male, 75% diabetic), 71% had a mature AVF/AVG at dialysis initiation. eGFR decline accelerated in the last 6 months prior to dialysis in patients with a catheter (median, from -6.0 to -16.3 mL/min/1.73 m²/year, P < 0.001), while a significant deceleration of eGFR decline was seen after vascular access creation in those with AVF/AVG (median, from -5.6 to -4.1 mL/min/1.73 m²/year, P < 0.001). Findings were independent of AVF/AVG maturation status and were robust in adjusted models. Conclusions. The creation of pre-dialysis AVF/AVG appears to be associated with eGFR slope deceleration and, consequently, may delay the onset of dialysis initiation in advanced CKD patients. [ABSTRACT FROM AUTHOR]

Published
2017
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3. Arteriovenous access placement and renal function decline

Author

Alessandro Gasparini, Ulrika Hanh Lundstrom, Ulf Hedin, Fergus Caskey, Juan Jesus Carrero, and Marie Evans

Subjects
Male, medicine.medical_specialty, chronic kidney disease progression, medicine.medical_treatment, Population, eGFR decline, Urology, Renal function, Catheterization, Peritoneal dialysis, Cohort Studies, Arteriovenous Shunt, Surgical, Risk Factors, medicine, Humans, Renal Insufficiency, Chronic, education, Dialysis, Aged, Sweden, Transplantation, education.field_of_study, business.industry, Middle Aged, medicine.disease, Comorbidity, Confidence interval, haemodialysis, peritoneal dialysis, Nephrology, arteriovenous access, Cohort, Kidney Failure, Chronic, Female, Hemodialysis, business, Vascular Access Devices, Glomerular Filtration Rate
Abstract

Background There is controversial evidence on whether arteriovenous access (AVA) placement may protect renal function and hence should be considered in the timing of access placement. This study aimed to investigate the association between AVA placement and estimated glomerular filtration rate (eGFR) decline as compared with the placement of a peritoneal dialysis catheter (PDC) at a similar time point. Methods We studied a cohort of 744 pre-dialysis patients in Stockholm, Sweden, who underwent surgery for AVA or PDC between 2006 and 2012. Data on comorbidity, medication and laboratory measures were collected 100 days before and after surgery. Patients were followed until dialysis start, death or 100 days, whichever came first. The primary outcome was difference in eGFR decline after AVA surgery compared with PDC. Decline in eGFR was estimated through linear mixed models with random intercept and slope, before and after surgery. Results There were 435 AVA and 309 PDC patients. The AVA patients had higher eGFR (8.1 mL/min/1.73 m2 versus 7.0 mL/min/1.73 m2) and less rapid eGFR decline before surgery (−5.6 mL/min/1.73 m2/year compared with −6.7 mL/min/1.73 m2/year for PDC). We found no difference in eGFR decline after surgery in AVA patients compared with PDC patients [AVA progressed 0.26 (95% confidence interval −0.88 to 0.35) mL/min/1.73 m2/year faster after surgery compared with PDC]. Conclusions There was no significant difference in eGFR decline after placement of an AVA compared with a PDC. Both forms of access were associated with reduced eGFR decline in our population. The need for dialysis remains the main determinant for timing of access surgery.

Published
2019
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5. FP126IGA NEPHROPATHY: MEST-C SCORE AGGREGATIONS ASSOCIATED WITH DISTINCT RATES OF EGFR DECLINE

Author

Josefina Santos, Sofia Correia, Joana Tavares, António Cabrita, Andreia Campos, Jorge Malheiro, Ana I. Gómez de Castro, Sofia Santos, and Filipa Silva

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Internal medicine, medicine, Glomerulonephritis iga, Egfr decline, medicine.disease, business, Gastroenterology, Nephropathy
Published
2019
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7. FO022BARDOXOLONE METHYL PREVENTS EGFR DECLINE IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 4 AND TYPE 2 DIABETES - POST-HOC ANALYSES FROM BEACON

Author

Glenn M. Chertow, David G. Warnock, Colin J. Meyer, Melanie Chin, Megan O'Grady, Christoph Wanner, Angie Goldsberry, Pablo E. Pergola, George L. Bakris, Lesley A. Inker, and Geoffrey A. Block

Subjects
Oncology, Transplantation, medicine.medical_specialty, Post hoc, business.industry, Type 2 diabetes, medicine.disease, Egfr decline, 03 medical and health sciences, Chronic kidney disease stage 4, 0302 clinical medicine, Nephrology, Internal medicine, medicine, In patient, 030212 general & internal medicine, business, 030217 neurology & neurosurgery
Published
2018
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8. CKD progression: a risky business

Author

Holly Kramer and Alex R. Chang

Subjects
Male, medicine.medical_specialty, Disease, Egfr decline, Gastroenterology, Body Mass Index, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, medicine, Obese group, Humans, Obesity, Renal Insufficiency, Chronic, Transplantation, Creatinine, business.industry, Significant difference, medicine.disease, Endocrinology, chemistry, Nephrology, Female, business, Kidney disease
Abstract

established Stage 3–5 CKD in the absence of diabetes [9]. Using serum creatinine measured annually, GFR was estimated (eGFR) using the Modification of Diet in Renal disease Formula. Change in eGFR was then assessed by obesity presence defined as a BMI >30 kg/m 2 . A total of 131 patients with BMI ≥30 kg/m 2 were included and BMI in this group ranged from 30.0 to 52.4 kg/m 2 . Among the 368 patients with BMI

Published
2012
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