Search

Your search keyword '"Marc A. Seelen"' showing total 6 results
Start Over Author "Marc A. Seelen" Journal nephrology dialysis transplantation
6 results on '"Marc A. Seelen"'

1. The lectin pathway in renal disease

Author

Mohamed R. Daha, Stefan P Berger, Mariana Gaya da Costa, Marc A. Seelen, and Felix Poppelaars

Subjects
0301 basic medicine, kidney, NEPHROPATHY, PATHOGENESIS, Lupus nephritis, GLOMERULAR ACTIVATION, lectin pathway, BINDING PROTEIN, C4D, Nephropathy, 03 medical and health sciences, Complement inhibitor, Lectins, medicine, Animals, Humans, complement, DEPOSITION, Transplantation, Kidney, Complement component 3, Effector, business.industry, MASP-2, ASSOCIATION, medicine.disease, Complement system, PATTERN, 030104 developmental biology, medicine.anatomical_structure, Nephrology, DEFECT, Lectin pathway, Immunology, ischaemia reperfusion injury, Kidney Diseases, business, COMPLEMENT ACTIVATION, Signal Transduction
Abstract

The complement system is composed of a network of at least 40 proteins, which significantly contributes to health and disease. The lectin pathway (LP) is one of three pathways that can activate the complement system. Next to protection of the host against pathogens, the LP has been shown to play a crucial role in multiple renal diseases as well as during renal replacement therapy. Therefore, several complement-targeted drugs are currently being explored in clinical trials. Among these complement inhibitors, specific LP inhibitors are also being tested in renal abnormalities such as in immunoglobulin A nephropathy and lupus nephritis. Using various in vitro models, Yaseen et al. (Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement component 3 (C3) in absence of C4 and/or C2. FASEB J 2017; 31: 2210-2219) showed that Mannan-associated serine protease2 can directly activate C3 thereby bypassing C2 and C4 in the activation of the LP. These new findings broaden our understanding of the mechanisms of complement activation and could potentially impact our strategies to inhibit the LP in renal diseases. In support of these findings, we present data of human renal biopsies, demonstrating the occurrence of the LP bypass mechanism in vivo. In conclusion, this review provides a detailed overview of the LP and clarifies the recently described bypass mechanism and its relevance. Finally, we speculate on the role of the C4 bypass mechanism in other renal diseases.

Published
2018

2. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 1

Author

Masayuki Iyoda, Taihei Suzuki, Jung Eun Lee, Margherita Conrieri, Angel Sevillano, Katsuyuki Nagatoya, Shankar Prasad Nagaraju, Nicoletta Mezzina, Augusta Praça, A. Malesci, Bjørn Egil Vikse, Tajana Zeljkovic Vrkic, Fumihiko Sasai, Giuseppe Paolo Segoloni, Maki Shinzawa, Terumasa Hayashi, Yutaka Yamaguchi, Maria Elena Donadio, Inês Ferreira, Ioanna Labropoulou, Luca Vergano, Yoshikuni Nagayama, Manuel A Podestà, Guida Meneses, Takayuki Kuragano, Gisele V. Fernandes, Manohar Bairy, Yasuyuki Nagasawa, Ayse Serra Artan, Vedran Premuzic, Barbara Trezzi, Carla Guidi, Manuel Pestana, Makoto Watanabe, Donatella Vizza, Francisco Remédio, Rune Bjørneklett, Niranjan Ambekar, Evangelina Mérida, Narayan Prasad, Ana Cristina Matos, George Toulkeridis, In Mi Han, Enrique Morales, Mohit Kumar Rai, Federica Chiale, Kenichi Sumida, Ann Merethe Vågane, E. Mariz, Adrian Zugravu, Andreas Kronbichler, Michael A. Rudnicki, Praga Manuel, Maria Skoularopoulou, Maria Paola Puccinelli, Mustafa Güllülü, Helena Viana, Loredana Colla, Vasudeva Guddattu, Sung-Bae Park, Sung Jin Moon, Eduardo Gutiérrez, Hirokatsu Atsumi, Junichi Hoshino, Rajeevalochana Parthasarathy, Nimet Aktas, Renzo Bonofilgio, Carla Henriques, Ana Huerta, Jelena Kos, David Cucchiari, Gener Ismail, Renato Alberto Sinico, Anna Varberg Reisæter, Hideki Yamaya, Iuliana Andreiana, Atsushi Yamauchi, Bernardo Faria, Francesca Maria Bosetti, Noriko Hayami, Vincenzo Cantaluppi, Yoshitaka Isaka, Swapnil Karnik, Aydin Turkmen, Alexei Smirnov, Ljiljana Fodor, Jinhyuk Paek, Alberto Boido, Shinichi Uchida, Abdulmecit Yildiz, Takanori Shibata, Sei Sasaki, Xiao-Yan Wei, Ravindra Prabhu, Tiziana Stellato, Roser Torra, Eunah Hwang, Kazuyuki Tasaki, Luigi Biancone, Gutierrez-Solis Elena, Clarissa J. B. Carvalho, Gabriel Mircescu, Ana Teresa Nunes, Elisabet Ars, Tomokazu Okado, Hui Wang, Vanja Ivković, Tushar Anil Dighe, Katsuhito Ihara, Norifumi Hayashi, Roxana Jurubita, Aysegul Oruc, Yasar Caliskan, Mehmet Sukru Sever, Atul Sajgure, Aikaterini Papagianni, Katarzyna Koscielska-Kasprzak, Francesca Leone, Mario Laganović, Archana Buch, Daisuke Komukai, Carina Ferreira, Olga Galkina, Marian Klinger, Sandra Karanović, Manuela Bianciotto, Srinivas Kosuru, Maria Céu Santos, Maurizio Gallieni, Manuel Praga, Yuan-Qing Tian, Ken Iseri, Peter Påhlsson, Kenmei Takaichi, Vikas Agarwal, Manuel Burdese, Aritoshi Kida, Giulio Mengozzi, Giovanni Camussi, Yasutaka Yamamoto, Tomohiro Saito, Seiichi Matsuo, Enyu Imai, Yuki Shindo-Hirai, Edite Pereira, Nida Oztop, Gert Mayer, Tatemitsu Rai, Rosanna Coppo, Hiroshi Okuyama, Dong Ho Shin, Soichiro Iimori, Danilo Lofaro, Hiroki Adachi, Yasemin Ozluk, Maria Alina Gomes de Mattos Cavalcante, Michael C. Carlsson, Bulent Gul, Abhay Sadre, Shunsuke Goto, Vasilii Sipovskii, Kei Fukami, Hiroki Nishiwaki, Tatsuya Suwabe, Daniela Finocchietti, Yuki Matsui, Takshi Nakanishi, Ashwini Sharma, Teresa Papalia, Marijana Cˇorić, Marco D'Amico, Caro-Espada Paula Jara, Francesco Mollica, Licia Peruzzi, Yukihiro Wada, Roberta Camilla, Agata Mollica, E. O. Bogdanova, Raluca Bobeica, Cai-Li Wang, Eugen Mandache, Francesco Reggiani, Joaquim Calado, Li Lv, Elena Saganova, Fernanda Carvalho, Halil Yazici, Yan-Hui Zhang, Elisa Loiacono, Christos Bantis, Teresa Cavero, Salvatore Badalamenti, Hakon Leffler, Sigrid Lundberg, Tarun Jeloka, Ligia Petrescu, Luca Besso, Alline S. A. Oliveira, Stratis Kasimatis, Thomas Knoop, Davide Medica, Germana Daidola, E. Hernandez, Mana Yahiro, Rojas-Rivera Jorge Enrique, João M. Frazão, Kouki Mise, Toshiaki Suzuki, Yoshihiro Kuno, Atul Mulay, Jun Ito, Katarzyna Gniewek, George Efstratiadis, Marijana Ćorić, Jara Caro, Maria Stangou, Aysun Aksoy, Fernando Nolasco, Katarzyna Jakuszko, Paolo Gigliotti, Tae Hyun Yoo, Takeshi Hasegawa, Hideki Fujii, Ricardo Neto, Simona Stancu, Susana Sampaio, Camila Barbosa L Oliveira, Sindhura Lakshmi Koulmane Laxminarayana, Alaattin Yildiz, Shigeo Hara, Kei Matsumoto, Ludmila Taran, Nikoleta Maria Kouri, Shinichi Nishi, Andreea Avram, Zivka Dika, Nobuharu Kaneshima, Charan Bhadrappa Bale, Gian Marco Ghiggeri, Ashio Yoshimura, Lei Nan, Rachele Gallo, Keiji Fujimoto, Alessandro Amore, Mårten Segelmark, Luís H. B. C. Sette, Francesca Brunini, Bojan Jelaković, Lucila Maria Valente, Ryohei Yamamoto, Andreea Andronesi, Julia Kerschbaum, Inna Lastauka, Mohamed R. Daha, Akhilesh Jaiswal, Ni-Ya Jia, Jayraj Korpe, Shinichi Akiyama, Domenico Santoro, Marc A. Seelen, Ebru Acikgoz, Shoichi Maruyama, Anna Perri, Hitoshi Yokoyama, Magdalena Krajewska, Brijesh Yadav, Hyungjong Kim, Irina Zubina, Tatsuya Shoji, Yoshifumi Ubara, Claudio Angelini, Margareta Fištrek Prlić, Ian Proletov, Kentaro Nakai, Isin Kilicaslan, Antonella Radice, Prachi Kate, Sayuri Hamahata, Jose Antonio Moreno, and Marijana Zivko

Subjects
Transplantation, medicine.medical_specialty, Pediatrics, Primary (chemistry), Nephrology, business.industry, Alternative medicine, medicine, business, Intensive care medicine
Published
2014

3. Heparin/heparan sulphate interactions with complement--a possible target for reduction of renal function loss?

Author

Gerjan Navis, Jacob van den Born, Mareike K. S. Richter, Ditmer T. Talsma, Marc A. Seelen, Mohamed R. Daha, and Azadeh Zaferani

Subjects
renal failure, FACTOR-H, medicine.medical_treatment, Kidney, urologic and male genital diseases, ALTERNATIVE PATHWAY, C1-inhibitor, ACTIVATION, medicine, Animals, Humans, ALLOGRAFT-REJECTION, C1 INHIBITOR, Renal replacement therapy, REPERFUSION INJURY, complement system, Dialysis, GLYCOSAMINOGLYCANS, HEPARAN-SULFATE, Transplantation, Innate immune system, biology, Heparin, business.industry, Acute kidney injury, Complement System Proteins, medicine.disease, PROTEIN INTERACTIONS, Complement system, BINDING-SITE, Nephrology, Immunology, Disease Progression, biology.protein, Alternative complement pathway, Kidney Failure, Chronic, proteoglycans, Heparitin Sulfate, business
Abstract

Current management of end-stage renal failure is based on renal replacement therapy by dialysis or transplantation. Increased occurrence of renal failure in both native and transplanted kidneys indicates a need for novel therapies to stop or limit the progression of the disease. Acute kidney injury and proteinuria are major risk factors in the development of renal failure. In this regard, innate immunity plays an important role in the pathogenesis of renal diseases in both native and transplanted kidneys. The complement system is a major humoral part of innate defense. Next to the well-known complement activators, quite a number of the complement factors react with proteoglycans (PGs) both on cellular membranes and in the extracellular compartment. Therefore, these interactions might serve as targets for intervention. In this review, the current knowledge of interactions between PGs and complement is reviewed, and additionally the options for interference in the progression of renal disease are discussed.

Published
2013

4. MP060THE EFFECT OF IMATINIB IN ESTABLISHED FIBROSIS USING HUMAN PRECISION-CUT KIDNEY SLICES

Author

Henricus A. M. Mutsaers, Peter Olinga, Marc A. Seelen, Elisabeth G. D. Stribos, Miriam Boersema, Emilia Bigaeva, and Harry van Goor

Subjects
Transplantation, medicine.medical_specialty, Kidney, medicine.anatomical_structure, Nephrology, Fibrosis, business.industry, Urology, medicine, Imatinib, medicine.disease, business, medicine.drug
Published
2017

6. SP468LOW MANNOSE-BINDING LECTINLEVELS PREDICT CARDIOVASCULAR DISEASE IN HEMODIALYSIS PATIENTS

Author

Felix Poppelaars, Mariana Gaya da Costa, Stefan P Berger, Solmaz Assa, Anita H Meter-Arkema, Mohamed R Daha, Willem J Van Son, Casper FM Franssen, and Marc AJ Seelen

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Mannose binding, Internal medicine, medicine.medical_treatment, medicine, Disease, Hemodialysis, business, Gastroenterology
Published
2016

Catalog

Books, media, physical & digital resources
See catalog results