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1. Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases

Author

Claude Philippon, Brent R. Weil, Gilles Laurent, Guy Rostoker, G. Lagrue, and J. Laurent

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Nephrosis, Biopsy, Statistics as Topic, urologic and male genital diseases, Gastroenterology, Models, Biological, Sensitivity and Specificity, Predictive Value of Tests, Internal medicine, medicine, Humans, Minimal change disease, Child, Aged, Proteinuria, medicine.diagnostic_test, urogenital system, business.industry, Nephrosis, Lipoid, Glomerulonephritis, Middle Aged, medicine.disease, Prognosis, female genital diseases and pregnancy complications, Endocrinology, Predictive value of tests, Corticosteroid, Female, Steroids, medicine.symptom, business, Nephrotic syndrome
Abstract

In order to predict the steroid response in lipoid nephrosis (LN), we studied age, sex, proteinuria level, histological features and proteinuria selectivity index (SI; ratio between IgG and transferrin clearances) in 52 LN cases (minimal-change disease: n = 39; focal glomerulosclerosis+IgM nephropathy: n = 13). The multivariate analysis showed that age, sex and proteinuria level were not contributive, whereas histology and SI were. The predictive value of SI was much higher than that of histological type (McFadden's r2: 47% vs. 22%, p0.001). Thus, SI should be systemically assessed in idiopathic nephrotic syndrome for reviewing the pathologic classification obtained by histology. However, if its prognostic value is lower than that of selectivity, initial renal biopsy remains necessary for diagnosis in adults.

Published
1993

2. Contents, Vol. 44, 1986

Author

G. Lagrue, R. Nakazawa, M.H. Park, P. Ena, Jing-nan Zhou, R. Matesanz, H. Kajiyama, Teruo Asamato, Takayuki Inoue, R. Shainkin-Kestenbaum, P. Stanziale, Linda Pead, Sohji Nagase, F.P. Schena, N. Glorioso, M. Ciccarelli, Carlo Feletti, A. Dvilansky, Hitoshi Yokoyama, L. Capotondo, Robert A.P. Koene, M. Bertoli, G. Pertosa, Andries J. Hoitsma, E. Hosaka, B. Flamion, Hirotoshi Morii, Paul G. G. Gerlag, Andrew R. Rosenberg, G. Romagnoli, V. Lorenzo, K. Hamaguchi, A. Rappelli, C. Germinario, L. Chieco-Bianchi, Jing-chuan Wu, Q. Maggiore, A.J. Adler, Dalla Gassa, I. Nathan, P. Mols, P. Cauchie, Henk E. Sluiter, L. Guisasola, D.G. Struijk, V.E. Andreucci, Isao Ishikawa, A. Muiño, Sergio Stefoni, J.L. Teruel, Jack F.M. Wetzels, D. Cerimele, Yoshitaka Koshino, Neville J. Howard, J.G. Altozano, R.T. Krediet, G. Decaux, Y. Nomura, U. Vertolli, J. Ortuño, Rosalind Maskell, Seiichiro Tarui, C. Chaimovitz, Mitsuharu Narita, J.M. López-Gomez, Han-wei Zhu, Yoshiki Matsushita, F. Valderrabano, A. Ebihara, Norio Kono, Takashi Inoue, Kazumasa Aoyagi, Ming-wei Zhang, F. Mallamaci, J. Rubin, H. Shishido, Mitsuo Takahashi, M. Balletta, E.W. Boeschoten, Jie-zhun Wu, Y. Winikoff, R.J. van Ketel, G.M. Berlyne, Chi-shou Hou, P. Madeddu, E. Sansoni, Hisamitsu Nakahashi, P. Dessì-Fulgheri, M. De Mia, L. Arisz, Y. Kawahara, C.L. Pirani, R. Robeva, K. Iwashita, F. Delwiche, M. Bernini, Hiroshi Kida, Tsutomu Tabata, A. Vangelista, Teruo Okamoto, Toshio Abe, Hisao Mabuchi, F. García Martin, Nobu Hattori, Kiichiro Kikunami, R. Robles, A. Torres, Harvey C. Gonick, T. Yokoyama, Vittorio Bonomini, V. D’Agati, U. Buoncristiani, Esther Lu, Herbert J. Kramer, J.M. Gonzalez-Posada, C. Zoccali, G. Venkat Raman, E. Gaggiotti, J. Laurent, Shizuo Tojo, A. Fujimura, N. Di Paolo, L. Orte, A. De Rossi, Phillip J. Emder, H.A. Lee, P. Rossi, and G.B. Appel

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1986
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3. Contents, Vol. 34, 1983

Author

Dimitrios G. Oreopoulos, Yuji Nagura, G. Decaux, T. Bertani, Michinobu Hatano, Minoru Harada, Hiroyuki Ohi, Thomas G. Murray, A. Martínez Amenós, Patricio Silva, S. Garancini, B. Maziere, Ann Locniskar, A. De Mouzon Cambon, L. Carreras, George E. Digenis, S. Rabinovich, P. Moriniere, H. Rama, Hans H. Koepke, Nobuyuki Yoshizawa, N.P. Mallick, P.J. Meuniere, Barry R. Walker, J.C. Ansquer, G. Lagrue, N. Duquesnoy, J. Alsina, Lazaro Gotloib, J. Manos, Koichi Matsumoto, Alan Medline, Seymour Rosen, J.L. Sebert, Allen Sugarman, S. Abu-Regiaba, Hisashi Katayama, L. Ballada, David M. Roxe, Robert S. Brown, S. Glasberg, L. Olesnicky, David J. Greenblatt, C.D. Short, Takayuki Fujita, Kotaro Osakabe, J. Laurent, Patricia R. Audet, G. Roncari, A. Fournier, A. Caralps, Subramanyam Santhanam, C.L. Pirani, I. Dumont, D. Kuntz, and L. Gastaldi

Subjects
Traditional medicine, business.industry, Medicine, business
Published
1983
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4. Is Adult Idiopathic Nephrotic Syndrome Food Allergy?

Author

R. Robeva, C. Bruneau, Guy Rostoker, G. Lagrue, and J. Laurent

Subjects
medicine.medical_specialty, Allergy, Proteinuria, medicine.diagnostic_test, business.industry, Radioallergosorbent test, Disease, medicine.disease, Idiopathic Nephrotic Syndrome, Gastroenterology, Antigen, Food allergy, Internal medicine, Immunology, medicine, medicine.symptom, business, Nephrotic syndrome
Abstract

To evaluate the prevalence of food hypersensitivity in idiopathic nephrotic syndrome (INS), an oligoantigenic diet was given for 10 days to 13 patients with INS who had not steadily responded to corticosteroids; 5 of these patients were corticodependent, 3 were corticoresistant and 5 had multiple relapses. A history of allergy was present in 8 cases and an increase in total serum IgE levels in 6. Sensitivity to food antigens was documented by skin tests in 5, by the radioallergosarbent test (RAST) in 5 and by the human basophil degranulation test (HBDT) in 11. At the end of the oligoantigenic diet, proteinuria was significantly reduced in the 13 patients as compared to the initial level. It decreased by more than 50% in 9 patients and disappeared completely in 5. It seems that an oligoantigenic diet is helpful in cases of INS that do not respond to corticosteroids. This argues for a role of food hypersensitivity in this disease and suggests that avoidance of specific foods on the longer term may be of benefit. This diet must be tried in INS before the initiation of immunosuppressive therapy.

Published
1987
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5. Serum IgE in Primary Glomerular Diseases

Author

G. Hirbec, S. Kestenbaum, Gilles Laurent, Ansquer Jc, J. Laurent, G. Lagrue, Nebout T, and C. Noirot

Subjects
Adult, Hypersensitivity, Immediate, Male, medicine.medical_specialty, Allergy, Adolescent, Immunoglobulin E, Gastroenterology, Radioimmunosorbent Test, Serum ige, Glomerulonephritis, Internal medicine, medicine, Animals, Humans, Glomerular diseases, Aged, biology, Glomerulosclerosis, Focal Segmental, business.industry, Nephrosis, Lipoid, Middle Aged, medicine.disease, Rats, Endocrinology, biology.protein, Female, Geometric mean, business
Abstract

Serum IgE was measured by RIST test in 181 adult subjects, with log transformation. In 24 controls the geometric mean was 109 IU/ml, with an upper limit (geometric mean +/- 2 SD) of 460 IU/ml. 157 cases of glomerulonephritis (GN) classified according to light and immunofluorescence microscopy were studied. Serum IgE was significantly elevated in 39 lipoid nephrosis patients (p less than 0.001, with 21 levels greater than 460 IU/ml), 21 focal and segmental glomerulosclerosis (p less than 0.05, with 8 levels greater than 460 IU/ml) and 42 membranous GN (p less than 0.01, with 10 levels greater than 460 IU/ml). In 27 membrano-proliferative GN and 28 IgA GN, serum IgE was not different from controls with respectively 4 and 3 levels greater than 460 IU/ml. In addition, the lipoid nephrosis IgE geometric mean is 493 IU/ml, which is keeping with the high incidence of atopic troubles. The significance of raised serum IgE was discussed.

Published
1984
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8. Buckley's syndrome and membranoproliferative glomerulonephritis

Author

J. Laurent, A. Branellec, G. Lagrue, and L. Dubertret

Subjects
Adult, Male, medicine.medical_specialty, Immunoglobulin E, Dermatitis, Atopic, Glomerulonephritis, Hypergammaglobulinemia, Membranoproliferative glomerulonephritis, otorhinolaryngologic diseases, medicine, Humans, Sinusitis, biology, business.industry, Syndrome, Buckley's syndrome, medicine.disease, Dermatology, Recurrent sinusitis, body regions, Chemotaxis, Leukocyte, biology.protein, business, Granulocytes
Abstract

A 30-year-old patient with chronic atopic eczema, recurrent sinusitis and membranoproliferative type I glomerulonephritis (MPGN) is presented. Features of the Buckley hyper-IgE syndrome were present w

Published
1982

9. The vascular permeability factor is a T lymphocyte product

Author

Heslan Jm, A. Branellec, G. Lagrue, and J. Laurent

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, Lymphokines, Nephrotic Syndrome, business.industry, Vascular Endothelial Growth Factors, T-Lymphocytes, T lymphocyte, Middle Aged, Lymphocyte Activation, Vascular Permeability Factor, Text mining, Product (mathematics), Immunology, Medicine, Humans, Female, business, Cells, Cultured
Published
1986

10. Antiproteinuric effect of captopril in primary glomerular disease

Author

J. Laurent, R. Robeva, and G. Lagrue

Subjects
medicine.medical_specialty, Primary (chemistry), Captopril, business.industry, Nephrosis, Lipoid, Urology, Glomerulonephritis, IGA, Proteinuria, Glomerulonephritis, Medicine, Humans, Glomerular disease, business, medicine.drug
Published
1987

11. Is adult idiopathic nephrotic syndrome food allergy? Value of oligoantigenic diets

Author

J, Laurent, G, Rostoker, R, Robeva, C, Bruneau, and G, Lagrue

Subjects
Adult, Male, Proteinuria, Nephrotic Syndrome, Radioallergosorbent Test, Humans, Female, Middle Aged, Food Hypersensitivity, Aged
Abstract

To evaluate the prevalence of food hypersensitivity in idiopathic nephrotic syndrome (INS), an oligoantigenic diet was given for 10 days to 13 patients with INS who had not steadily responded to corticosteroids; 5 of these patients were corticodependent, 3 were corticoresistant and 5 had multiple relapses. A history of allergy was present in 8 cases and an increase in total serum IgE levels in 6. Sensitivity to food antigens was documented by skin tests in 5, by the radioallergosarbent test (RAST) in 5 and by the human basophil degranulation test (HBDT) in 11. At the end of the oligoantigenic diet, proteinuria was significantly reduced in the 13 patients as compared to the initial level. It decreased by more than 50% in 9 patients and disappeared completely in 5. It seems that an oligoantigenic diet is helpful in cases of INS that do not respond to corticosteroids. This argues for a role of food hypersensitivity in this disease and suggests that avoidance of specific foods on the longer term may be of benefit. This diet must be tried in INS before the initiation of immunosuppressive therapy.

Published
1987

12. Basophil sensitization for food allergens in idiopathic nephrotic syndrome

Author

J. Laurent, D. Belghiti, G. Lagrue, Heslan Jm, and J. Sainte-Laudy

Subjects
Male, Allergy, Meat, Nephrotic Syndrome, Swine, Eggs, Flour, Wheat flour, Basophil, Immunoglobulin E, Food allergy, Immunopathology, medicine, Animals, Humans, Sensitization, Triticum, biology, business.industry, food and beverages, Allergens, medicine.disease, Basophils, Proteinuria, medicine.anatomical_structure, Immunology, biology.protein, Cattle, Female, business, Nephrotic syndrome, Food Hypersensitivity
Abstract

To estimate food sensitization, the human basophil degranulation test (HBDT), usually used for allergy diagnosis, was performed in 34 idiopathic nephrotic syndrome (INS) patients, classified as minimal change glomerular disease, with or without atopic manifestations, and in 19 blood donors; five food allergens (wheat flour, cow's milk, whole egg, beef and pork) were investigated. The HBDT was positive in 22 out of the 34 INS (64%) and in 1 out of the 19 blood donors (p less than 0.001). The test was 9 times positive for wheat flour, 9 times for pork, 6 times for cow's milk, 6 times for beef and 5 times for whole egg. Moreover in 13 cases, the basophil sensitization was present for two or three of these food allergens in the same patient. A direct causal relationship between food sensitization and INS cannot be drawn from this study: it might be demonstrated only by elemental or oligoantigenic diet prior to specific avoidances.

Published
1986

13. Lack of antireticulin and IgA antiendomysium antibodies in sera of patients with primary IgA nephropathy associated with circulating IgA antibodies to gliadin

Author

A. Branellec, S. Bourhala, J. Laurent, Claude André, Guy Rostoker, and G. Lagrue

Subjects
Adult, biology, business.industry, Muscles, Glomerulonephritis, IGA, Middle Aged, Antibodies, Gliadin, Antiendomysium antibodies, Immunoglobulin A, Reticulin, Immunology, biology.protein, Medicine, Humans, Antibody, business, Primary IgA nephropathy
Published
1988

14. Subject Index, Vol. 34, 1983

Author

D. Kuntz, L. Gastaldi, S. Garancini, A. De Mouzon Cambon, Hiroyuki Ohi, B. Maziere, G. Decaux, J. Laurent, Patricia R. Audet, S. Glasberg, Robert S. Brown, P.J. Meuniere, S. Abu-Regiaba, David M. Roxe, Hans H. Koepke, L. Carreras, G. Lagrue, C.L. Pirani, J.C. Ansquer, J. Alsina, Alan Medline, I. Dumont, Allen Sugarman, A. Caralps, Yuji Nagura, Subramanyam Santhanam, J. Manos, George E. Digenis, Barry R. Walker, Patricio Silva, David J. Greenblatt, Seymour Rosen, G. Roncari, Koichi Matsumoto, C.D. Short, A. Fournier, Kotaro Osakabe, Dimitrios G. Oreopoulos, Thomas G. Murray, A. Martínez Amenós, P. Moriniere, H. Rama, L. Ballada, Lazaro Gotloib, N.P. Mallick, T. Bertani, Michinobu Hatano, Minoru Harada, L. Olesnicky, Takayuki Fujita, S. Rabinovich, Nobuyuki Yoshizawa, N. Duquesnoy, Ann Locniskar, J.L. Sebert, and Hisashi Katayama

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1983
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15. Membranoproliferative Glomerulonephritis Associated with Buckley’s Syndrome, Treated with Cyclosporin

Author

G. Lagrue, R. Robeva, and J. Laurent

Subjects
Adult, Male, medicine.medical_specialty, business.industry, Cyclosporins, Syndrome, Immunoglobulin E, Buckley's syndrome, medicine.disease, Dermatology, Proteinuria, Glomerulonephritis, Hypergammaglobulinemia, Immunology, Membranoproliferative glomerulonephritis, Humans, Medicine, Child, business
Abstract

A 38-year old patient had been suffering, since the age of 17, from membranoproliferative glomerulonephritis associated with chronic atopic eczema and recurrent sinusitis. Bouts of eczema with severe itching occurred simultaneously with sinusitis and proteinuria. Permanently extreme serum IgE levels (greater than 10,000 IU/ml), defective neutrophil chemotaxis and monocyte phagocytic function (Buckley's syndrome) were present. Because cyclosporin reduces excessive IgE levels in Brown Norway rats with mercuric chloride nephritis, we gave the patient this drug in daily doses of 3-4 mg/kg. A dramatic improvement resulted within a few days: itching disappeared, the eczema progressively cleared, proteinuria decreased to less than 0.5 g/day and serum IgE levels to 4000 KIU/l. Reduction of dosage was followed by recurrence of all clinical and biological signs. In spite of the improvement obtained, serum creatinine levels, which were initially high (200-250 mumol/l) rose up to 300 mumol/l after one year of treatment.

Published
1986
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16. Subject Index, Vol. 44, 1986

Author

J. Ortuño, Rosalind Maskell, M. De Mia, C.L. Pirani, Seiichiro Tarui, E. Gaggiotti, Kiichiro Kikunami, Carlo Feletti, A. Torres, J. Laurent, Harvey C. Gonick, T. Yokoyama, Y. Nomura, Mitsuo Takahashi, E. Sansoni, J.M. Gonzalez-Posada, Shizuo Tojo, A. Fujimura, V. Lorenzo, L. Guisasola, D.G. Struijk, Hisao Mabuchi, F. Mallamaci, Sergio Stefoni, N. Glorioso, M. Ciccarelli, G. Venkat Raman, U. Vertolli, F. Valderrabano, A. Dvilansky, Toshio Abe, P. Cauchie, Q. Maggiore, A.J. Adler, Dalla Gassa, Henk E. Sluiter, Takashi Inoue, I. Nathan, Jie-zhun Wu, L. Capotondo, Hiroshi Kida, R. Shainkin-Kestenbaum, G. Decaux, Andries J. Hoitsma, Hitoshi Yokoyama, A. Vangelista, P. Stanziale, Herbert J. Kramer, Linda Pead, V.E. Andreucci, J.M. López-Gomez, Teruo Asamato, P. Mols, C. Zoccali, Vittorio Bonomini, V. D’Agati, J. Rubin, R. Robles, G. Lagrue, M. Bertoli, Tsutomu Tabata, Teruo Okamoto, Yoshiki Matsushita, G. Pertosa, E. Hosaka, Y. Winikoff, G.M. Berlyne, M.H. Park, H. Kajiyama, R. Matesanz, F. García Martin, Robert A.P. Koene, U. Buoncristiani, Paul G. G. Gerlag, Andrew R. Rosenberg, Isao Ishikawa, G. Romagnoli, Jing-chuan Wu, J.L. Teruel, Jack F.M. Wetzels, F. Delwiche, Esther Lu, Han-wei Zhu, P. Madeddu, P. Dessì-Fulgheri, Neville J. Howard, J.G. Altozano, A. Ebihara, L. Arisz, Y. Kawahara, Mitsuharu Narita, A. Muiño, R. Nakazawa, Takayuki Inoue, Norio Kono, Kazumasa Aoyagi, P. Ena, Koshino Y, R. Robeva, F.P. Schena, K. Iwashita, H. Shishido, E.W. Boeschoten, Phillip J. Emder, H.A. Lee, P. Rossi, G.B. Appel, L. Orte, A. De Rossi, N. Di Paolo, C. Chaimovitz, B. Flamion, Hirotoshi Morii, M. Bernini, K. Hamaguchi, Nobu Hattori, Jing-nan Zhou, Sohji Nagase, M. Balletta, R.J. van Ketel, Chi-shou Hou, Hisamitsu Nakahashi, A. Rappelli, C. Germinario, L. Chieco-Bianchi, D. Cerimele, R.T. Krediet, and Ming-wei Zhang

Subjects
Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1986
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17. HLA-DR 7 in Adult Lipoid Nephrosis Patients

Author

Ansquer Jc, G. Lagrue, C. Bracq, De Mouzon Cambon A, and J. Laurent

Subjects
Hla dr7 antigen, medicine.medical_specialty, business.industry, Nephrosis, Significant difference, medicine.disease, Nephrosis lipoid, Endocrinology, Internal medicine, Immunology, HLA-DR, medicine, Age of onset, business
Published
1983
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18. Proteinuria selectivity index--prognostic value in lipoid nephrosis and related diseases.

Author

Laurent J, Philippon C, Lagrue G, Laurent G, Weil B, and Rostoker G

Subjects
Adolescent, Adult, Aged, Biopsy, Child, Female, Humans, Male, Middle Aged, Models, Biological, Nephrosis, Lipoid diagnosis, Nephrosis, Lipoid pathology, Predictive Value of Tests, Prognosis, Sensitivity and Specificity, Statistics as Topic methods, Steroids, Nephrosis, Lipoid urine, Proteinuria urine
Abstract

In order to predict the steroid response in lipoid nephrosis (LN), we studied age, sex, proteinuria level, histological features and proteinuria selectivity index (SI; ratio between IgG and transferrin clearances) in 52 LN cases (minimal-change disease: n = 39; focal glomerulosclerosis+IgM nephropathy: n = 13). The multivariate analysis showed that age, sex and proteinuria level were not contributive, whereas histology and SI were. The predictive value of SI was much higher than that of histological type (McFadden's r2: 47% vs. 22%, p < 0.001). Thus, SI should be systemically assessed in idiopathic nephrotic syndrome for reviewing the pathologic classification obtained by histology. However, if its prognostic value is lower than that of selectivity, initial renal biopsy remains necessary for diagnosis in adults.

Published
1993
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22. Is adult idiopathic nephrotic syndrome food allergy? Value of oligoantigenic diets.

Author

Laurent J, Rostoker G, Robeva R, Bruneau C, and Lagrue G

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Nephrotic Syndrome diet therapy, Nephrotic Syndrome urine, Proteinuria urine, Radioallergosorbent Test, Food Hypersensitivity complications, Nephrotic Syndrome etiology
Abstract

To evaluate the prevalence of food hypersensitivity in idiopathic nephrotic syndrome (INS), an oligoantigenic diet was given for 10 days to 13 patients with INS who had not steadily responded to corticosteroids; 5 of these patients were corticodependent, 3 were corticoresistant and 5 had multiple relapses. A history of allergy was present in 8 cases and an increase in total serum IgE levels in 6. Sensitivity to food antigens was documented by skin tests in 5, by the radioallergosarbent test (RAST) in 5 and by the human basophil degranulation test (HBDT) in 11. At the end of the oligoantigenic diet, proteinuria was significantly reduced in the 13 patients as compared to the initial level. It decreased by more than 50% in 9 patients and disappeared completely in 5. It seems that an oligoantigenic diet is helpful in cases of INS that do not respond to corticosteroids. This argues for a role of food hypersensitivity in this disease and suggests that avoidance of specific foods on the longer term may be of benefit. This diet must be tried in INS before the initiation of immunosuppressive therapy.

Published
1987
Full Text
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23. Serum IgE in primary glomerular diseases.

Author

Lagrue G, Laurent J, Hirbec G, Ansquer JC, Noirot C, Laurent G, Nebout T, and Kestenbaum S

Subjects
Adolescent, Adult, Aged, Animals, Female, Glomerulonephritis classification, Glomerulosclerosis, Focal Segmental immunology, Humans, Hypersensitivity, Immediate immunology, Male, Middle Aged, Radioimmunosorbent Test, Rats, Glomerulonephritis immunology, Immunoglobulin E analysis, Nephrosis, Lipoid immunology
Abstract

Serum IgE was measured by RIST test in 181 adult subjects, with log transformation. In 24 controls the geometric mean was 109 IU/ml, with an upper limit (geometric mean +/- 2 SD) of 460 IU/ml. 157 cases of glomerulonephritis (GN) classified according to light and immunofluorescence microscopy were studied. Serum IgE was significantly elevated in 39 lipoid nephrosis patients (p less than 0.001, with 21 levels greater than 460 IU/ml), 21 focal and segmental glomerulosclerosis (p less than 0.05, with 8 levels greater than 460 IU/ml) and 42 membranous GN (p less than 0.01, with 10 levels greater than 460 IU/ml). In 27 membrano-proliferative GN and 28 IgA GN, serum IgE was not different from controls with respectively 4 and 3 levels greater than 460 IU/ml. In addition, the lipoid nephrosis IgE geometric mean is 493 IU/ml, which is keeping with the high incidence of atopic troubles. The significance of raised serum IgE was discussed.

Published
1984
Full Text
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25. Basophil sensitization for food allergens in idiopathic nephrotic syndrome.

Author

Lagrue G, Heslan JM, Belghiti D, Sainte-Laudy J, and Laurent J

Subjects
Animals, Cattle, Eggs, Female, Flour, Humans, Immunoglobulin E analysis, Male, Meat, Proteinuria, Swine, Triticum, Allergens, Basophils immunology, Food Hypersensitivity, Nephrotic Syndrome immunology
Abstract

To estimate food sensitization, the human basophil degranulation test (HBDT), usually used for allergy diagnosis, was performed in 34 idiopathic nephrotic syndrome (INS) patients, classified as minimal change glomerular disease, with or without atopic manifestations, and in 19 blood donors; five food allergens (wheat flour, cow's milk, whole egg, beef and pork) were investigated. The HBDT was positive in 22 out of the 34 INS (64%) and in 1 out of the 19 blood donors (p less than 0.001). The test was 9 times positive for wheat flour, 9 times for pork, 6 times for cow's milk, 6 times for beef and 5 times for whole egg. Moreover in 13 cases, the basophil sensitization was present for two or three of these food allergens in the same patient. A direct causal relationship between food sensitization and INS cannot be drawn from this study: it might be demonstrated only by elemental or oligoantigenic diet prior to specific avoidances.

Published
1986
Full Text
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