1. Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury
- Author
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Martin Richard Späth, K. Johanna R. Hoyer-Allo, Felix C Koehler, and Roman-Ulrich Müller
- Subjects
Male ,business.industry ,Organ protection ,Acute kidney injury ,Caloric theory ,Clinical Practice: Mini-Review ,Acute Kidney Injury ,urologic and male genital diseases ,Kidney ,medicine.disease ,Bioinformatics ,Stress resistance ,Humans ,Medicine ,Female ,Renal protection ,business ,Caloric Restriction - Abstract
Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.
- Published
- 2021
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