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Start Over Author "Kalavsky E" Journal neuro endocrinology letters
17 results on '"Kalavsky E"'

1. Bacterial meningitis after sinusitis and otitis media: ear, nose, throat infections are still the commonest risk factors for the community acquired meningitis

Author

Lesnakova, A., Holeckova, K., Kolenova, A., Streharova, A., Kisac, P., Beno, P., Kalavsky, E., Sramka, M., Ondrusova, A., Benca, J., Seckova, S., Sladeckova, V., Bartkovjak, M., Bukovinova, P., Hvizdak, F., Lengyel, P., Sabo, I., Rudinsky, B., Bauer, F., Luzica, R., Bielova, M., Karvaj, M., Huttova, M., Wiczmandyova, D., Svabova, V., Findova, L., Kutna, K., Deadline, J., Diana, E., and Kiwou, M.

Subjects
Community-Acquired Infections, Diabetes Complications, Otitis Media, Risk Factors, Outcome Assessment, Health Care, Humans, Wounds and Injuries, Sinusitis, Alcohol-Related Disorders, Anti-Bacterial Agents, Meningitis, Bacterial
Abstract

We investigated how many cases of bacterial meningitis in our national survey were associated with sinusitis or otitis media. Among 372 cases of bacterial meningitis within our nationwide 17 years survey, 201 cases were community acquired (CBM) and in 40 (20%) otitis media or sinusitis acuta/chronica were reported 1-5 weeks before onset of CBM. Diabetes mellitus (20% vs. 7.5%, p=0.01), alcohol abuse (35% vs. 15.4%, p=0.003) and trauma (30% vs. 14.9%, p=0.02) were significantly associated with CBM after ENT infections. Concerning etiology, CBM after sinusitis/otitis was insignificantly associated with pneumococcal etiology (50% vs. 33.8 %, NS) and significantly associated with other (L. monocytogenes, Str. agalactiae) bacterial agents (9.9 % vs. 25 %, p=0.008) . However those significant differences for new ENT related CBM had no impact on mortality (12.4 % vs. 5%, NS), failure after initial antibiotics (10 % vs. 9.5%, NS) and neurologic sequellae (12.5 % vs. 15.4 %, NS).

Published
2007

2. Bacterial meningitis after craniocerebral trauma in the community

Author

Holeckova, K., Kolenova, A., Lesnakova, A., Steno, J., Streharova, A., Kisac, P., Beno, P., Kalavsky, E., Sramka, M., Ondrusova, A., Benca, J., Seckova, S., Sladeckova, V., Bartkovjak, M., Bukovinova, P., Hvizdak, P., Lengyel, P., Svabova, V., Findova, L., Kutna, K., Deadline, J., Johnson, J., Namulanda, V., Juma, O., Okoth, V., Kovac, M., Rudinsky, B., Bauer, F., Karvaj, M., Sabo, I., Huttova, M., Kenderessy, P., Nosko, P., Paulikova, T., Rusnak, R., Povinsky, J., and Galla, S.

Subjects
Cohort Studies, Community-Acquired Infections, Bacteria, Risk Factors, Outcome Assessment, Health Care, Craniocerebral Trauma, Humans, Brain Damage, Chronic, Alcohol-Related Disorders, Anti-Bacterial Agents, Meningitis, Bacterial
Abstract

Craniocerebral trauma is one of major risk factors for development of meningitis. We reviewed 30 cases of bacterial meningitis occurring in community after craniocerebral trauma. Alcohol abuse was significant risk factor occurring in trauma patients with meningitis present in 50% in our cohort (p=0.0001). The most common pathogen in posttraumatic meningitis was Str. pneumoniae (90% vs. 33.8%, p=0.0001). However mortality was very low, only 5% probably because of early diagnosis and treatment of patients at risk for bacterial meningitis but neurologic sequellea were significantly more common (p=0.00001) in patients after craniocerebral trauma.

Published
2007

3. Predictors of inferior outcome in community acquired bacterial meningitis

Author

Streharova, A., Krcmery, V., Kisac, P., Kalavsky, E., Holeckova, K., Lesnakova, A., Luzinsky, L., Adamkovicova, E., Pavlikova, Z., Spilakova, N., Kacunova, B., Dovalova, V., Wiczmandyova, O., Spanik, S., Liskova, A., Chovancova, D., Kovac, M., Ondrusova, A., Bauer, F., Benca, J., Rudinsky, B., Sramka, M., Kralova, J., Krsakova, A., Krumpolcova, M., Findova, L., Svabova, V., Sladeckova, V., Seckova, S., Saniova, J., Pavlicova, B., Taziarova, M., Bukovinova, P., Kolenova, A., Horvathova, D., Hvizdak, F., Luzica, R., Rolnikova, B., Bocakova, A., Grey, E., Bielova, M., Huttova, E., Sabo, I., and Jalili, N.

Subjects
Community-Acquired Infections, Alcoholism, Slovakia, Chi-Square Distribution, Risk Factors, Brain Injuries, Diabetes Mellitus, Humans, Brain Damage, Chronic, Treatment Failure, Gram-Negative Bacterial Infections, Meningitis, Bacterial
Abstract

The aim of this study was to assess mortality and sequellae within cases from Nationwide survey of community acquired meningitis and identify risk factors for inferior outcome. Risk factors such as underlying disease (diabetes mellitus, cancer, trauma, neonatal age, splenectomy, alcoholism, sepsis, other infections), etiology, clinical symptoms and outcome (death, improvement and cured after modifications of ATB therapy, cured without change of therapy, cured with neurologic sequellae) were recorded and analysed with univariate analysis (chi2 or t test for trends, CDC Atlanta 2004). Analysing risk factors for inferior outcome (death or cured with neurologic sequellae), we compared patients who died or survived with neurologic sequellae to all patients with community acquired bacterial meningitis. Univariate analysis showed that trauma (p0.05), alcohol abuse (p0.05), diabetes, S. aureus (p0.05) and gram-negative etiology (A. baumannii, Ps. aeruginosa or Enterobacteriaceae) (36% vs. 11,9%, p0.05) were predicting inferior outcome. Analysing risk factors for treatment failure (death or failed but cured after change of antibiotic treatment) prior sepsis (34.1% vs. 13.9%, p0.01) and gram-negative etiology (25% vs. 11.9%, p0.02) were statistically significant predictors of treatment failure. Neisseria meningitis had less failures (p0.05). Concerning infection associated mortality again diabetes mellitus (p0.05), alcoholism (p0.05) staphylococcal and gram-negative etiology (p0.05) were significant predictors of death. N. meningitis had surprisingly less treatment failures (appropriate and rapid initial therapy). Neurologic sequellae were more common in patients with alcohol abuse (p0.05), craniocerbral trauma (p0.05) and less common in meningitis with pneumococcal etiology (p0.05).

Published
2007

4. Etiology, Risk Factors and Outcome of 1003 Cases of Infective Endocarditis from a 33-year National Survey in the Slovak Republic: An increasing proportion of elderly patients.

Author

Krčméry V, Hricak V, Fischer V, Mrazova M, Brnova J, Hulman M, Outrata R, Bauer F, Kalavsky E, Babela R, Mikolasova G, Spanik S, Karvaj M, and Marks P

Abstract

Background: Infective endocarditis (IE) is still a significant cause of mortality in European hospitals, despite of the fact, that large nationwide studies were performed in last twenty years and pathogens are well known. The aim of the study was to assess risk factors, mortality, etiology and proportion of elderly patients within a longitudinal nation wide survey of infectious endocarditis in Slovakia., Patients and Methods: Etiology, risk factors and outcome of 1003 cases of infective endocarditis (IE) in Slovakia over the last 33 years have been assessed., Results: The majority of IE were caused by Staphylococci (28.3%), 15.6% were due to Viridans streptococci, 10% due to Enterococci, 8.2% by gram-negative bacteria, Acinetobacter baumannii and Pseudomonas aeruginosa, 3.7% by other organisms and 31.0% of all cases were culture negative. The following risk factors were recorded: age > 65 (36.8%), rheumatic fever (15.3%), dental surgery (8.7%), previous non-cardiological surgery (8.2 %), neoplasia (8.1%), diabetes (7.8%), any endoscopy (8.5%) and dialysis (4.6%). All patients were treated with antimicrobials, 507 (51%) also with surgery. Survival rate at day 60 after diagnosis was 88.1% (n=883). Only age >65 (34.3% vs. 49.5%, p=0.045) and persistent bacteremia (with three or more positive blood cultures 15.7% vs. 34.5%, p=0,001) were significantly associated with higher attributable mortality. Concerning risk factors, etiology and therapeutic strategies, rheumatic fever and neoplasia showed decrease in tendency. Dental surgery and tonsillitis were less frequent as well (26.7% vs. 2%, p<0,001 and 16% vs. 1%, p<0.001). There was a significant shift in etiology after 1997: culture-negative endocarditis was surprisingly more frequently observed in the 2007-2017 period than before and represented 10.7% of all cases in 1984-1990 in comparison to 25.1-25.6% in 2007-2010 and 2011-2017. Staphylococci decreased from 48% to 29.6% (2007-2017), but are still major pathogens. Persistent bacteremia (3 or more positive blood cultures 5.3% vs. 24.7%, p<0,001) was less commonly observed within the 1st period (1984-1990) in comparison to 2007-2010. More patients in the 1st period (1984-1990) had embolization complications of IE than in the fifth and sixth period (2007-2017) (76 vs. 16.3% p<0.001). CNS embolization decreased from 14% to less than 5% (p<0.003). Attributable mortality was lower too (26.7% vs. 9.5%, p<0.001) because of increased proportion of cardiac surgery in the treatment of IE in 2007-2017 in comparison to 1984-1990., Conclusions: Study has showed significant shifts in etiology, risk factors and complications over the observed time periods in Slovakia.

Published
2019

5. Fungal neuroinfections and fungaemia: unexpected increase of mortality from invasive fungal infections in 2005-2011 in comparison to 1989-1998: analysis of 210 cases.

Author

Demitrovicova A, Liskova A, Valach M, Izakovic M, Noge A, Baranova J, Kalatova D, Syrovatkova L, Velicova J, Bugykova B, Gulasova I, Seinova D, Mikolasova G, Mutalova M, Pilkova M, Szabo I, Findova L, Madarasz I, Stanzyk M, Mikulickova D, Blazekova M, Jankechova M, Slezakova Z, Kuriplachova G, Visnovsky J, Obrocnikova A, Blumm M, Blumm B, Wolfram S, Zeleny P, Otrubova J, Rudinsky B, Nagyova Z, Vravcova M, Kajaba J, Jexova S, Oravec S, Toth S, Klobucka S, Gerigh J, Schumann F, Ambra R, Bandura P, Bonnack C, Kubisova Z, Palo M, Kalavsky E, Drgona L, Mahesvaari R, and Riedl J

Abstract

Objective: In this short communication we compared the data of fungaemia cases in Slovak hospitals from 1989-1998 published in 1999-2000 with data from 2005-2011., Methods: Risk factors, etiology and outcome of fungaemia between two periods (1989-1998 vs. 2005-2011) were compared and risk factors for death assessed by univariate analysis (CDC 2006 Statistical Package)., Results: In comparison to 1989-1998 when only amphotericin B and fluconazole has been used (55%), in 2005-2011 only 35.2% patients received FLU, but 26.4% received voriconazole, 22% caspofungin and anidulafungin and about 6.6% lipid formulations of Amphotericin B. In etiology, while in 1989-1998 only 37.1% (115/310) represented non-albicans Candida (NAC) and non-Candida yeasts in 2005-2011 already reached 63.7%. The significant increase of breakthrough fungaemia may be a sign of inappropriate empiric therapy.

Published
2013

6. Comparison of postsurgical and community acquired bacterial meningitis--analysis of 372 cases within a nationwide survey.

Author

Streharova A, Benca J, Holeckova K, Balik J, Sula I, Lesnakova A, Luzinsky L, Pavlikova Z, Adamkovicova E, Spilakova N, Kacunova B, Dovalova V, Kisac P, Beno P, Kalavsky E, Sramka M, Benka J, Ondrusova A, Seckova S, Sladeckova V, Kolenova A, Bartkovjak M, Bukovinova P, Hvizdak F, Lengyel P, Bielova M, Wiczmandyova O, Svabova V, Findova L, Kutna K, Deadline J, Diana E, Krumpolcova M, Kiwou M, Steno J, Stankovic I, Bauer F, Kovac M, Huttova M, Taziarova M, Luzica R, Saniova B, Rudinsky B, Sabo I, Karvaj M, and Johnson MJ

Subjects
Community-Acquired Infections complications, Community-Acquired Infections microbiology, Community-Acquired Infections mortality, Cross Infection complications, Cross Infection microbiology, Humans, Meningitis, Bacterial etiology, Meningitis, Bacterial microbiology, Meningitis, Bacterial therapy, Neurosurgical Procedures adverse effects, Postoperative Complications microbiology, Risk Factors, Slovakia epidemiology, Statistics, Nonparametric, Survival Analysis, Treatment Outcome, Cross Infection mortality, Meningitis, Bacterial mortality, Postoperative Complications mortality
Abstract

The aim of this study was to assess if differences in etiology and risk factors among 372 cases of bacterial meningitis acquired after surgery (PM) or in community (CBM) have impact on outcome of infected patients. Among 372 cases of bacterial meningitis within last 17 years from 10 major Slovak hospitals, 171 were PM and 201 CBM. Etiology, risk factors such as underlying disease, cancer, diabetes alcoholism, surgery, VLBW, ENT infections, trauma, sepsis were recorded and mortality, survival with sequellae, therapy failure were compared in both groups. Significant differences in etiology and risk factors between both groups were reported. Those after neurosurgery had more frequently Coagulase negative staphylococci (p<0.001), Enterobacteriaceae (p=0.01) and Acinetobacter baumannii (p=0.0008) isolated from CSF and vice versa Streptococcus pneumoniae (p<0.001), Neisseria meningitis (p<0.001) and Haemophillus influenza (p=0.0009) were more commonly isolated from CSF in CBM. Neurosurgery (p<0.001), sepsis (p=0.006), VLBW neonates (p=0.00002) and cancer (p=0.0007) were more common in PM and alcohol abuse (p<0.001) as well as otitis/sinusitis (p<0.001) and Roma ethnic group (p=0.001) in CAM. Initial treatment success was significantly more frequently observed among CAM (p<0.001) but cure after modification was more common in PM (p=0.002). Therefore outcome in both groups was similar (14.6% vs. 12.4%, p=NS).

Published
2007

7. Meningitis in excessive alcohol consumers acquired in the community.

Author

Benca J, Bartosovic I, Kalavsky E, Kisac P, Hanobik F, Bielova M, and Duong LS

Subjects
Adult, Community-Acquired Infections epidemiology, Health Surveys, Humans, Male, Meningitis, Pneumococcal complications, Meningitis, Pneumococcal epidemiology, Risk Factors, Slovakia epidemiology, Treatment Outcome, Alcoholism complications, Alcoholism epidemiology, Meningitis, Bacterial complications, Meningitis, Bacterial epidemiology
Abstract

Etiology, risk factors, treatment and outcome of 21 cases of bacterial meningitis diagnosed in excessive alcohol consumers within 5 years of national community acquired meningitis survey in Slovakia is reported.

Published
2007

8. The influence of wine Zweigeltrebe and Breslava Chateau Karvaj on blood pressure in healthy volunteers.

Author

Karvaj M, Beno P, and Kalavsky E

Subjects
Diastole, Dose-Response Relationship, Drug, Humans, Systole, Time Factors, Blood Pressure drug effects, Wine
Abstract

Efficacy of varies wine sorts on blood pressure in 21 healthy individuals was prospectively studied. White wine Breslava most significantly decreased systolic blood pressure in comparison to wines from supermarket Veltlin or Frankovka (Blaufränkisch, Caberner Franc) (Raca). Decrease in diastolic blood pressure is similar in both white wines Breslava respectively Veltlin. In the second experiment during 8 hours blood pressure measurement, white wine Breslava from Nove Zamky region more significantly decreased systolic blood pressure in comparison to Low Carpathian wines (region Raca). Both white wines significantly decreased diastolic blood pressure. Red wines from both regions did not have significant influence on systolic or diastolic blood pressure in doses of 1, 2 or 3 dcl.

Published
2007

9. Antimicrobial susceptibility of cerebrospinal isolates from patients with meningitis.

Author

Liskova A, Benca J, Kalavsky E, Kovac M, Rudinsky B, Ondrusova A, and Kiwou M

Subjects
Cefotaxime therapeutic use, Chloramphenicol therapeutic use, Drug Resistance, Microbial, Haemophilus Infections complications, Haemophilus Infections drug therapy, Haemophilus influenzae isolation & purification, Humans, Meningitis, Bacterial drug therapy, Meningitis, Bacterial etiology, Meningitis, Bacterial microbiology, Microbial Sensitivity Tests, Neisseria meningitidis isolation & purification, Ofloxacin therapeutic use, Penicillins therapeutic use, Staphylococcal Infections complications, Staphylococcal Infections drug therapy, Staphylococcus aureus isolation & purification, Streptococcus pneumoniae isolation & purification, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Anti-Bacterial Agents therapeutic use, Haemophilus influenzae drug effects, Meningitis, Bacterial cerebrospinal fluid, Neisseria meningitidis drug effects, Staphylococcus aureus drug effects, Streptococcus pneumoniae drug effects
Abstract

Str. pneumoniae isolates were susceptible to penicillin, all to also ofloxacin and chloramphenicol and cefotaxim and 39 (100%) to cotrimoxazol. Concerning S. aureus, all isolates 22 were susceptible to oxacillin and chloramphenicol, and 21 also to cotrimoxazol. All N. meningitidis isolates but one-10 of all were susceptible to penicillin, all to cefotaxim, chloramphenicol and cotrimoxazol. All H.influenzae isolates were susceptible to ampicillin and chloramphenicol, as well as to ofloxacin and cotrimoxazol. Those surprisingly high susceptibilities to rather "old" antibiotics may be explained by low antibiotic consumption, accessibility and therefore low usage which is a key promoter of resistance both in community and hospital.

Published
2007

11. Moderate alcohol consumption may improve mental capacity in elderly.

Author

Kalavsky E

Subjects
Cardiovascular System drug effects, Humans, Neuropsychological Tests, Aged psychology, Alcohol Drinking psychology, Central Nervous System Depressants pharmacology, Cognition drug effects, Ethanol pharmacology
Abstract

The studies on the effect of moderate alcohol consumption on mental capacity in elderly and inflammatory markers in coronary heart disease are reviewed.

Published
2007

12. Nosocomial meningitis caused by Staphylococcus other than S. aureus in children: multicentre study.

Author

Bauer F, Huttova M, Rudinsky B, Benca J, Taziarova M, Kovac M, Balent I, Sulla I, Jarcuska P, Kalavsky E, Kisac P, Holeckova K, Ondrusova A, Kralinsky K, Stankovic I, Steno J, Pevalova L, Grey E, Mrazova M, and Spanik S

Subjects
Anti-Bacterial Agents therapeutic use, Child, Child, Preschool, Cross Infection drug therapy, Cross Infection etiology, Humans, Infant, Infant, Newborn, Meningitis, Bacterial drug therapy, Meningitis, Bacterial etiology, Neurosurgical Procedures adverse effects, Postoperative Complications drug therapy, Retrospective Studies, Staphylococcaceae isolation & purification, Staphylococcal Infections drug therapy, Ventriculoperitoneal Shunt adverse effects, Cross Infection microbiology, Meningitis, Bacterial microbiology, Postoperative Complications microbiology, Staphylococcal Infections complications
Abstract

Analysing 101 cases of nosocomial meningitis due to staphylococci other than S. aureus within last 15 years, coagulase negative staphylococci represented the commonest pathogen. Major risk factor for staphylococcal meningitis was prior neurosurgery, mainly ventriculoperitoneal shunt insertion. Ten of 101 cases were caused by glycopeptide intermediate resistant strains in patients pretreated with multiple combination of antibiotics including vancomycin and shunt exchanges: 76% of strains were also oxacillin resistant.

Published
2007

13. Neuroinfections complicating foreign body implants after perinatal trauma or meningitis in 60 children.

Author

Rudinsky B, Bauer F, Kalavsky M, Huttova M, Sramka M, Kalavsky E, Benca J, Karvaj M, Jarcuska P, Liskova A, Kralinsky K, Ondrusova A, Taziarova M, Pevalova L, Kovac M, and Miklosko J

Subjects
Brain Injuries complications, Brain Injuries microbiology, Brain Injuries surgery, Child, Child, Preschool, Foreign Bodies microbiology, Humans, Hydrocephalus complications, Hydrocephalus surgery, Infant, Infant, Newborn, Infant, Very Low Birth Weight, Intracranial Hemorrhages complications, Meningitis microbiology, Neurosurgical Procedures adverse effects, Prosthesis-Related Infections microbiology, Cerebrospinal Fluid Shunts adverse effects, Meningitis complications, Prosthesis-Related Infections complications, Pseudomonas Infections complications, Staphylococcal Infections complications
Abstract

Meningitis after artificial implants in 60 children, mainly after foreign body infections (FBI) was caused more frequently by coagulase negative staphylococci and Ps. aeruginosa than other organisms and was significantly associated with perinatal trauma, hydrocephalus, haemorrhage or VLBW and had more neurologic sequels despite mortality was similar to other nosocomial meningitis.

Published
2007

14. Infectious diseases in disaster areas/catastrophes.

Author

Benca J, Kalavsky E, Miklosko J, Rudinsky B, Taziarova M, and McKenzie F

Subjects
Humans, Terrorism, Warfare, Communicable Disease Control methods, Communicable Diseases epidemiology, Disaster Planning methods, Disasters classification, Disease Outbreaks prevention & control
Abstract

There is very little data and no prospective research possible in the field of catastrophic medicine (disaster medicine) including infectious diseases. This minireview tries to contribute to the pathogenesis and outcome of infectious diseases in areas after anthropogenic (war, genocide, terrorist attack, industrial disasters) and non anthropogenic (natural) catastrophes (earthquake, floods, tsunamis, hurricanes, volcano eruptions). Therefore ISC received a proposal to create a working group on infectious diseases in areas after catastrophes, better to understand epidemiology, prevention and therapy of infectious diseases occurring in conjunction to various anthropogenic and non anthropogenic (natural) disasters.

Published
2007

15. Infectious embolisation to the central nervous system from endocarditis: analyses of 99 cases.

Author

Karvaj M, Krcmery V, Kalavsky E, Kisac P, Hricak V, Mlkvy P, Kovac M, Bauer F, Rudinsky B, and Sramka M

Subjects
Adolescent, Adult, Aged, Anti-Infective Agents therapeutic use, Bacteremia complications, Bacteremia microbiology, Central Nervous System Diseases mortality, Child, Child, Preschool, Cohort Studies, Endocarditis, Bacterial microbiology, Endocarditis, Bacterial therapy, Enterococcus, Gram-Positive Bacterial Infections therapy, Heart Failure microbiology, Humans, Intracranial Embolism mortality, Middle Aged, Central Nervous System Diseases etiology, Endocarditis, Bacterial complications, Gram-Positive Bacterial Infections complications, Heart Failure complications, Intracranial Embolism etiology
Abstract

Within a cohort of 606 cases of infective endocarditis, 263 were complicated and 99 embolizing, of them 32 to the central nervous system (CNS). Significant predictors of CNS embolisation were inappropriate therapy (p<0.01) and enterococcal etiology (p<0.01). Mortality in patients with CNS emboli was 65% what was significantly higher than in cases without embolisation - 15% (p<0.01).

Published
2007

16. Pseudomonas aeruginosa causing nosocomial meningitis in neonates and children: overview of 15 cases within 10 years.

Author

Ondrusova A, Kalavsky E, Rudinsky B, Freybergh FP, Bauer F, Miklosko J, Huttova M, Kisac P, and Cauda R

Subjects
Adolescent, Cefotaxime therapeutic use, Ceftazidime therapeutic use, Chi-Square Distribution, Child, Preschool, Chloramphenicol therapeutic use, Cross Infection drug therapy, Cross Infection mortality, Drug Therapy, Combination, Female, Gentamicins therapeutic use, Humans, Infant, Infant, Newborn, Male, Meningitis, Bacterial drug therapy, Meningitis, Bacterial mortality, Meropenem, Pseudomonas Infections drug therapy, Retrospective Studies, Risk Factors, Survival Analysis, Thienamycins therapeutic use, Anti-Bacterial Agents therapeutic use, Cross Infection microbiology, Meningitis, Bacterial microbiology, Pseudomonas Infections mortality
Abstract

Risk factors, therapy and outcome of 15 cases of nosocomial meningitis due to Pseudomonas aeruginosa is reviewed. No difference in risk factors was found, however mortality for Ps. aeruginosa was significantly higher (33.3 vs 15.1% p<0.04).

Published
2007

17. Neuroinfections and antimicrobials: do we need new molecules or new strategies?

Author

Kalavsky E, Kisac P, Huttova M, Benca J, and Krcmery V

Subjects
Brain Diseases drug therapy, Brain Diseases microbiology, Candidiasis drug therapy, Cross Infection microbiology, Fluconazole therapeutic use, Humans, Meningitis microbiology, Meropenem, Pseudomonas Infections drug therapy, Staphylococcal Infections drug therapy, Teicoplanin therapeutic use, Thienamycins therapeutic use, Anti-Infective Agents therapeutic use, Cross Infection drug therapy, Drug Resistance, Microbial, Meningitis drug therapy
Abstract

Within last 15 years, analyzing patterns of etiology and resistance in organisms causing neuroinfections, emergence of resistance has been observed in Slovakia in S. haemolyticus to teicoplanin (11%), Ps. aeruginosa and A. baumannii to meropenem (20%) and Candida spp. (non-albicans Candida spp.) to fluconazol (20%). There are no new antibiotics against carbapenem resistant Ps. aeruginosa and Acinetobacter baumannii.

Published
2007

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