1. The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system
- Author
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Ayşenur Karaduman, Utku Kaya, Elif Tugce Karoglu-Eravsar, Michelle M. Adams, Alaz Aydin, Hulusi Kafaligonul, Karaduman, Ayşenur, Karoğlu-Eravşar, Elif Tuğçe, Kaya, Utku, Aydın, Alaz, Adams, Michelle, and Kafalıgönül, Hulusi
- Subjects
0301 basic medicine ,Male ,Aging ,genetic structures ,Genotype ,media_common.quotation_subject ,Motion Perception ,Stimulation ,Motor Activity ,03 medical and health sciences ,0302 clinical medicine ,Contrast (vision) ,Animals ,Receptors, Cholinergic ,Motion perception ,Zebrafish ,Vision, Ocular ,media_common ,biology ,Behavior, Animal ,General Neuroscience ,Motion detection ,biology.organism_classification ,Visual motion ,Acetylcholine ,030104 developmental biology ,Direction ,Cholinergic system ,Optomotor response ,Visual Perception ,Female ,Neurology (clinical) ,sense organs ,Geriatrics and Gerontology ,Neuroscience ,030217 neurology & neurosurgery ,Photic Stimulation ,Developmental Biology - Abstract
Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and achesb55/ thorn mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were ageand genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging. (c) 2020 Elsevier Inc. All rights reserved.
- Published
- 2020