Search

Your search keyword '"Morgane Thomsen"' showing total 2 results
Start Over Author "Morgane Thomsen" Journal neurobiology of disease
2 results on '"Morgane Thomsen"'

1. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Author

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, and Ann M. Graybiel

Subjects
Striatum, M1 muscarinic receptor, Kir2, Dendritic excitability, Stereotypy, Amphetamine, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and levodopa-induced dyskinesia in Parkinson's disease. We demonstrate that genetic deletion of CDGI in mice disrupts dendritic, but not somatic, M1 muscarinic receptors (M1Rs) signaling in indirect pathway SPNs. Loss of CDGI reduced temporal integration of excitatory postsynaptic potentials at dendritic glutamatergic synapses and impaired the induction of activity-dependent long-term potentiation. CDGI deletion selectively increased psychostimulant-induced repetitive behaviors, disrupted sequence learning, and eliminated M1R blockade of cocaine self-administration. These findings place CDGI as a major, but previously unrecognized, mediator of cholinergic signaling in the striatum. The effects of CDGI deletion on the self-administration of drugs of abuse and its marked alterations in hyperkinetic extrapyramidal disorders highlight CDGI's therapeutic potential.

Published
2021
Full Text
View/download PDF

2. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Author

Magdalena Sauvage, Jill R. Crittenden, Shenyu Zhai, Cinzia Costa, Walker S. Jackson, Anne C. Smith, Veronica Ghiglieri, David E. Housman, David Sulzer, Ann M. Graybiel, Giuseppina Martella, D. James Surmeier, Takashi Kitsukawa, Eric Burguière, Karen A. Pescatore, Ellen M. Unterwald, Barbara Picconi, Hui Zhang, Morgane Thomsen, Paolo Calabresi, S. Barak Caine, McGovern Institute for Brain Research [Cambridge], Massachusetts Institute of Technology (MIT), Department of Brain and Cognitive Sciences, Feinberg School of Medicine, Northwestern University [Evanston], Graduate School of Frontier Biosciences [Osaka], Osaka University [Osaka], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), McLean Hospital [Belmont, Ma.], Harvard Medical School [Boston] (HMS), New York State Psychiatric Institute, Columbia University [New York], Università degli Studi di Perugia (UNIPG), Fondazione Santa Lucia [IRCCS], Clinical and Behavioral Neurology [IRCCS Santa Lucia], Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Linköping University (LIU), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, University of Arizona, Northwestern University Medical School [Chicago], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Jefferson (Philadelphia University + Thomas Jefferson University), IRCCS San Raffaele Pisana, Temple University School of Medicine, Università cattolica del Sacro Cuore [Roma] (Unicatt), Gestionnaire, Hal Sorbonne Université, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Perugia = University of Perugia (UNIPG)

Subjects
Male, [SDV]Life Sciences [q-bio], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Long-Term Potentiation, Striatum, Mice, 0302 clinical medicine, Cocaine, Extrapyramidal disorder, Drug addiction, Guanine Nucleotide Exchange Factors, Mice, Knockout, 0303 health sciences, Neuronal Plasticity, Self-administration, Long-term potentiation, M1 muscarinic receptor, 3. Good health, Neurology, Excitatory postsynaptic potential, LTP, Dendritic excitability, Amphetamine, Stereotypy, Kir2, Neurovetenskaper, RC321-571, Substance-Related Disorders, Neurosciences. Biological psychiatry. Neuropsychiatry, Biology, Hyperkinesis, Motor Activity, Medium spiny neuron, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, Glutamatergic, Basal Ganglia Diseases, Parasympathetic Nervous System, Animals, 030304 developmental biology, Receptor, Muscarinic M1, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Neurosciences, Excitatory Postsynaptic Potentials, Dendrites, Neostriatum, Synaptic plasticity, Synapses, Cholinergic, Central Nervous System Stimulants, Neuroscience, 030217 neurology & neurosurgery
Abstract

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntingtons disease and levodopa-induced dyskinesia in Parkinsons disease. We demonstrate that genetic deletion of CDGI in mice disrupts dendritic, but not somatic, M1 muscarinic receptors (M1Rs) signaling in indirect pathway SPNs. Loss of CDGI reduced temporal integration of excitatory postsynaptic potentials at dendritic glutamatergic synapses and impaired the induction of activity-dependent long-term potentiation. CDGI deletion selectively increased psychostimulant-induced repetitive behaviors, disrupted sequence learning, and eliminated M1R blockade of cocaine self-administration. These findings place CDGI as a major, but previously unrecognized, mediator of cholinergic signaling in the striatum. The effects of CDGI deletion on the selfadministration of drugs of abuse and its marked alterations in hyperkinetic extrapyramidal disorders highlight CDGIs therapeutic potential. Funding Agencies: William N. & Bernice E. Bumpus Foundation; Saks Kavanaugh Foundation; Simons Foundation; National Institute of Child Health and Development United States Department of Health & Human Services National Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [R37 HD028341]; James and Pat Poitras Research Fund; Stanley Center for Psychiatric Research at the Broad Institute; National Institute of Mental Health United States Department of Health & Human Services National Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [R01 MH071847, F32 MH065815]; National Institute on Aging United States Department of Health & Human Services National Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01 AG050548]; European Community FP7 - The-matic priority HEALTH contract [222918]; Ministry of Health; JPB Foundation; National Institute on Drug Abuse United States Department of Health & Human Services National Institutes of Health (NIH) - USANIH National Institute on Drug Abuse (NIDA) European Commission [R00 DA027825, R01 DA07418]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results