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Start Over Author "Kun Chen" Topic inflammation Journal neurochemical research
2 results on '"Kun Chen"'

2. Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats

Author

Tsung-Cheng Yin, Kun-Chen Lin, Hon-Kan Yip, John Y. Chiang, Chi-Ruei Huang, Yi-Ling Chen, Chien-Hui Yang, Tien-Hung Huang, Chi-Wen Luo, Pei-Hsun Sung, Kuan-Hung Chen, Hung-Fei Chen, Yi-Chen Li, and Yu-Huan Tsou

Subjects
0301 basic medicine, Extracorporeal Shockwave Therapy, Male, Pain Threshold, medicine.medical_specialty, Time Factors, Inflammation, medicine.disease_cause, Biochemistry, Antioxidants, Melatonin, Rats, Sprague-Dawley, 03 medical and health sciences, Cellular and Molecular Neuroscience, Random Allocation, 0302 clinical medicine, Dorsal root ganglion, Internal medicine, medicine, Animals, Chemistry, General Medicine, Rats, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Treatment Outcome, Apoptosis, Neuropathic pain, Neuralgia, Sciatic nerve, medicine.symptom, 030217 neurology & neurosurgery, Oxidative stress, Astrocyte, medicine.drug
Abstract

We evaluated the ability of extracorporeal shock wave (ECSW)-assisted melatonin (Mel) therapy to offer an additional benefit for alleviating the neuropathic pain (NP) in rats. Left sciatic nerve was subjected to chronic constriction injury (CCI) to induce NP. Animals (n = 30) were randomized into group 1 (sham-operated control), group 2 (CCI only), group 3 (CCI + ECSW), group 4 (CCI + Mel) and group 5 (CCI + ECSW + Mel). By days 15, 22 and 29 after CCI, the thermal paw withdrawal latency (TPWL) and mechanical paw withdrawal threshold (MPWT) were highest in group 1, lowest in group 2, significantly higher in group 5 than in groups 3 and 4, but they showed no difference between the later two groups (all p

Published
2018

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