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Your search keyword '"Sinensetin"' showing total 3 results
Start Over Descriptor "Sinensetin" Journal neurochemical research
3 results on '"Sinensetin"'

1. Sinensetin Attenuates Amyloid Beta25-35-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4/NF-κB Signaling Pathway.

Author

Zhi, Zhongwen, Tang, Xiaohong, Wang, Yuqian, Chen, Rui, and Ji, Hu

Subjects
*CELLULAR signal transduction, *NEUROTOXICOLOGY, *OXIDATIVE stress, *AMYLOID, *APOPTOSIS, *TOLL-like receptors
Abstract

Sinensetin (SIN) is an important active compound that exists widely in citrus plants, and has been reported to exhibit various pharmacological properties, including anti-oxidative, anti-inflammatory, and anti-tumor. This study was designed to examine whether SIN can protect against amyloid beta (Aβ)-induced neurotoxicity and to elucidate the underlying mechanism. Our results showed that pretreatment with SIN for 1 h, followed by co-treatment with Aβ plus SIN for 24 h, attenuated Aβ25-35-induced cell viability reduction, oxidative stress, inflammation, and apoptosis in a dose-dependent manner. Aβ25-35-induced upregulation of Toll-like receptor 4 (TLR4) expression and nuclear translocation of nuclear factor-kappaB (NF-κB) p65 subunit were inhibited by pretreatment with SIN. Furthermore, the protective effect of SIN was abrogated by TLR4 overexpression. Hence, our data suggested that SIN attenuated Aβ25-35-induced neurotoxicity through the TLR4/NF-κB pathway. [ABSTRACT FROM AUTHOR]

Published
2021
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3. Sinensetin Attenuates Amyloid Beta25-35-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4/NF-κB Signaling Pathway

Author

Rui Chen, Hu Ji, Xiaohong Tang, Yuqian Wang, and Zhongwen Zhi

Subjects
genetic structures, biology, Amyloid beta, viruses, fungi, Neurotoxicity, virus diseases, food and beverages, General Medicine, medicine.disease_cause, medicine.disease, Biochemistry, Cell biology, Cellular and Molecular Neuroscience, chemistry.chemical_compound, chemistry, Downregulation and upregulation, Apoptosis, medicine, biology.protein, Viability assay, Sinensetin, Signal transduction, Oxidative stress
Abstract

Sinensetin (SIN) is an important active compound that exists widely in citrus plants, and has been reported to exhibit various pharmacological properties, including anti-oxidative, anti-inflammatory, and anti-tumor. This study was designed to examine whether SIN can protect against amyloid beta (Aβ)-induced neurotoxicity and to elucidate the underlying mechanism. Our results showed that pretreatment with SIN for 1 h, followed by co-treatment with Aβ plus SIN for 24 h, attenuated Aβ25-35-induced cell viability reduction, oxidative stress, inflammation, and apoptosis in a dose-dependent manner. Aβ25-35-induced upregulation of Toll-like receptor 4 (TLR4) expression and nuclear translocation of nuclear factor-kappaB (NF-κB) p65 subunit were inhibited by pretreatment with SIN. Furthermore, the protective effect of SIN was abrogated by TLR4 overexpression. Hence, our data suggested that SIN attenuated Aβ25-35-induced neurotoxicity through the TLR4/NF-κB pathway.

Published
2021

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