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1. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers

Author

O'Toole, D., Grossman, A., Gross, D., Fave, G. D., Barkmanova, J., O'Connor, J., Pape, U. F., Plöckinger, U., Åkerström, G., Annibale, B., Arnold, R., Bajetta, E., Chen, Y. J., Costa, F., Couvelard, A., Davar, J., Herder, W. D., Eriksson, B., Falconi, M., Ferone, D., Gustafsson, B., Hyrdel, R., Ivan, D., Kaltsas, G., Kianmanesh, R., Klöppel, G., Knigge, U. P., Komminoth, P., Kos Kudla, B., Kwekkeboom, D., Lebtahi, R., Lewington, V., Mcnicol, A. M., Mitry, E., Nilsson, O., Öberg, K., Papotti, M., Pavel, M., Perren, A., Platania, M., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scheidhauer, K., Scoazec, J. Y., Sundin, A., Szpak, W., Taal, B., Vitek, P., Vullierme, M. P., and Wiedenmann, B.

Subjects
Endocrinology, Diabetes and Metabolism, Diagnostic accuracy, insulinoma, Neuroendocrine tumors, Bioinformatics, secretin, 0302 clinical medicine, Endocrinology, immune system diseases, cancer diagnosis, conference paper, Biochemical markers, biology, Urinary 5-hydroxyindoleacetic acid, Chromogranin A, Fasting, Hydroxyindoleacetic Acid, Diabetes and Metabolism, Neuroendocrine Tumors, priority journal, 030220 oncology & carcinogenesis, diagnostic accuracy, 5 hydroxyindoleacetic acid, neuroendocrine tumor, hormones, hormone substitutes, and hormone antagonists, Neuroendocrine tumor test, musculoskeletal diseases, medicine.medical_specialty, Standard of care, MEDLINE, 610 Medicine & health, 030209 endocrinology & metabolism, 03 medical and health sciences, Cellular and Molecular Neuroscience, Patient information, Internal medicine, gastrin, medicine, Humans, biochemistry, human, Insulinoma, Gastrinoma, gastrinoma, Endocrine and Autonomic Systems, business.industry, practice guideline, biochemical marker, chromogranin A, hypoglycemia, patient information, medicine.disease, body regions, biology.protein, 570 Life sciences, Biomarkers, business
Abstract

Biomarkers have been the mainstay in the diagnosis and follow-up of patients with neuroendocrine tumors (NETs) over the last few decades. In the beginning, secretory products from a variety of subtypes of NETs were regarded as biomarkers to follow during diagnosis and treatment: serotonin for small intestinal (SI) NETs, and gastrin and insulin for pancreatic NETs. However, it became evident that a large number of NETs were so-called nonfunctioning tumors without secreting substances that caused hormone-related symptoms. Therefore, it was necessary to develop so-called “general tumor markers.” The most important ones so far have been chromogranin A and neuron-specific enolase (NSE). Chromogranin A is the most important general biomarker for most NETs with a sensitivity and specificity somewhere between 60 and 90%. NSE has been a relevant biomarker for patients with high-grade tumors, particularly lung and gastrointestinal tract tumors. Serotonin and the breakdown product urinary 5-hydroxyindoleacetic acid (U-5-HIAA) is still an important marker for diagnosing and follow-up of SI NETs. Recently, 5-HIAA in plasma has been analyzed by high-performance liquid chromatography and fluorometric detection and has shown good agreement with U-5-HIAA analysis. In the future, we will see new tests including circulating tumor cells, circulating DNA and mRNA. Recently, a NET test has been developed analyzing gene transcripts in circulating blood. Preliminary data indicate high sensitivity and specificity for NETs. However, its precise role has to be validated in prospective randomized controlled trials which are ongoing right now.

Published
2017
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2. ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

Author

M. Pavel, E. Baudin, A. Couvelard, E. Krenning, K. Öberg, T. Steinmüller, M. Anlauf, B. Wiedenmann, R. Salazar, B. C. Conference Anlauf M, Arnold R, Bartsch D, Baudin E, Baum R, Brandi ML, Cadiot G, Costa F, Caplin M, Couvelard A, de Herder W, Delle Fave G, Denecke T, Eriksson B, Gress T, Gross D, Grossman A, Jensen R, Kaltsas G, Kelestimur F, Kianmanesh R, Klöppel G, Klose KJ, Knigge U, Komminoth P, Kos Kudla B, Krenning E, Kwekkeboom D, Lopes JM, Niederle B, Nilsson O, Öberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pascher A, Pavel M, Perren A, Plöckinger U, Rindi G, Ruszniewski P, Salazar R, Sasano H, Sauvanet A, Scoazec JY, Steinmüller T, Sundin A, Taal B, Tomassetti P, Van Cutsem E, Vullierme MP, Wiedenmann B., FALCONI , MASSIMO, M., Pavel, E., Baudin, A., Couvelard, E., Krenning, K., Öberg, T., Steinmüller, M., Anlauf, B., Wiedenmann, R., Salazar, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, Wiedenmann, B., and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, animal structures, Endocrinology, Diabetes and Metabolism, Intestinal Neoplasm, Neuroendocrine tumors, Biology, digestive system, Cellular and Molecular Neuroscience, Endocrinology, stomatognathic system, Internal medicine, Intestinal Neoplasms, medicine, Humans, Endocrine and Autonomic Systems, Liver Neoplasms, fungi, Midgut, Hindgut, Foregut, medicine.disease, Neuroendocrine Tumors, embryonic structures, Unknown primary, Neoplasms, Unknown Primary
Abstract

ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

Published
2012
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3. ENETS Consensus Guidelines for the Management of Patients with Neuroendocrine Neoplasms from the Jejuno-Ileum and the Appendix Including Goblet Cell Carcinomas

Author

U. Pape, A. Perren, B. Niederle, D. Gross, T. Gress, F. Costa, R. Arnold, T. Denecke, U. Plöckinger, R. Salazar, A. Grossman, B. C. Conference Anlauf M, Arnold R, Bartsch D, Baudin E, Baum R, Brandi ML, Cadiot G, Costa F, Caplin M, Couvelard A, de Herder W, Delle Fave G, Denecke T, Eriksson B, Gress T, Gross D, Grossman A, Jensen R, Kaltsas G, Kelestimur F, Kianmanesh R, Klöppel G, Klose KJ, Knigge U, Komminoth P, Kos Kudla B, Krenning E, Kwekkeboom D, Lopes JM, Niederle B, Nilsson O, Öberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pascher A, Pavel M, Perren A, Plöckinger U, Rindi G, Ruszniewski P, Salazar R, Sasano H, Sauvanet A, Scoazec JY, Steinmüller T, Sundin A, Taal B, Tomassetti P, Van Cutsem E, Vullierme MP, Wiedenmann B., FALCONI , MASSIMO, Erasmus MC other, U., Pape, A., Perren, B., Niederle, D., Gro, T., Gre, F., Costa, R., Arnold, T., Denecke, U., Plöckinger, R., Salazar, A., Grossman, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, and Wiedenmann, B.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, General surgery, University hospital, Appendix, Appendiceal neoplasms, Neuroendocrine Tumors, Cellular and Molecular Neuroscience, Jejunum, Endocrinology, medicine.anatomical_structure, Appendiceal Neoplasms, Ileum, Internal medicine, Intestinal Neoplasms, neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas, medicine, Humans, business
Abstract

a Division of Hepatology and Gastroenterology, Department of Internal Medicine, Campus Virchow-Klinikum, Charite-Universitatsmedizin Berlin, Berlin , Germany; b Department of Pathology, Universitatsspital, Zurich , Switzerland; c Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; d Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem , Israel; e Department of Internal Medicine, Philipps University, Marburg , Germany; f Hopital Sirio Libanes, Centro de Oncologia, Sao Paulo , Brazil; g Department of Radiology, Campus Virchow-Klinikum, Charite, University Medicine Berlin, Berlin , Germany; h Department of Oncology, Institut Catala d’Oncologia (IDIBELL), Barcelona , Spain; i Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford , UK

Published
2012
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4. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological Examinations

Author

A. Sundin, M. Vullierme, G. Kaltsas, U. Plöckinger, Akerström G, Annibale B, Arnold R, Bajetta E, Barkmanova J, Chen YJ, Costa F, Couvelard A, Davar J, de Herder W, Delle G, Eriksson B, Ferone D, Gross D, Grossman A, Gustafsson B, Hyrdel R, Ivan D, Kianmanesh R, Klöppel G, Knigge UP, Komminoth P, Kos Kudła B, Kwekkeboom D, Lebtahi R, Lewington V, McNicol AM, Mitry E, Nilsson O, Oberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pavel M, Perren A, Platania M, Rindi G, Ruszniewski P, Salazar R, Scarpa A, Scheidhauer K, Scoazec JY, Szpak W, Taal B, Vitek P, Wiedenmann B., FALCONI , MASSIMO, A., Sundin, M., Vullierme, G., Kaltsa, U., Plöckinger, Akerström, G, Annibale, B, Arnold, R, Bajetta, E, Barkmanova, J, Chen, Yj, Costa, F, Couvelard, A, Davar, J, de Herder, W, Delle, G, Eriksson, B, Falconi, Massimo, Ferone, D, Gross, D, Grossman, A, Gustafsson, B, Hyrdel, R, Ivan, D, Kianmanesh, R, Klöppel, G, Knigge, Up, Komminoth, P, Kos Kudła, B, Kwekkeboom, D, Lebtahi, R, Lewington, V, Mcnicol, Am, Mitry, E, Nilsson, O, Oberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pavel, M, Perren, A, Platania, M, Rindi, G, Ruszniewski, P, Salazar, R, Scarpa, A, Scheidhauer, K, Scoazec, Jy, Szpak, W, Taal, B, Vitek, P, and Wiedenmann, B.

Subjects
medicine.medical_specialty, radiodiagnosis, diagnostic imaging, Endocrinology, Diabetes and Metabolism, multidetector computed tomography, Diagnostic accuracy, Neuroendocrine tumors, cancer diagnosis, computer assisted tomography, conference paper, diagnostic accuracy, echography, human, medical documentation, medical society, neuroendocrine tumor, nuclear magnetic resonance imaging, patient information, practice guideline, priority journal, radiation dose, sensitivity and specificity, Cellular and Molecular Neuroscience, Endocrinology, X ray computed, Internal medicine, Multidetector computed tomography, medicine, Humans, Ultrasonography, Endocrine and Autonomic Systems, business.industry, General surgery, Radiation dose, medicine.disease, Magnetic Resonance Imaging, Medical documents, Neuroendocrine Tumors, Radiological weapon, Radiology, Tomography, X-Ray Computed, business
Abstract

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : Radiological Examinations

Published
2008
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5. Rare functioning pancreatic endocrine tumors

Author

O'Toole D, Salazar R, Kaltsas G, Couvelard A, De Herder WW, Hyrdel R, Nikou G, Krenning E, Vullierme MP, Caplin M, Jensen R, Eriksson B, Ahlman H, Arnold R, Bechstein WO, Cadiot G, Christ E, Chung D, Delle Fave G, Falchetti A, Ferone D, Goretzki P, Gross D, Hochhauser D, Keleştimur F, Kianmanesh R, Knapp W, Knigge UP, Komminoth P, Körner M, Kos Kudła B, Kvols L, Kwekkeboom DJ, Lewington V, Lopes JM, Manfredi R, McNicol AM, Mitry E, Niederle B, Nilsson O, Öberg K, O'Connor J, Pauwels S, Pape UF, Pavel M, Perren A, Plöckinger U, Ramage J, Ricke J, Rindi G, Ruszniewski P, Sauvanet A, Scarpa A, Scoazec JY, Sevilla Garcia MI, Steinmüller T, Sundin A, Taal B, Van Cutsem E, Wiedenmann B, Wildi S, Yao JC, Zgliczynski S., FALCONI , MASSIMO, Internal Medicine, Radiology & Nuclear Medicine, O'Toole, D, Salazar, R, Falconi, Massimo, Kaltsas, G, Couvelard, A, De Herder, Ww, Hyrdel, R, Nikou, G, Krenning, E, Vullierme, Mp, Caplin, M, Jensen, R, Eriksson, B, Ahlman, H, Arnold, R, Bechstein, Wo, Cadiot, G, Christ, E, Chung, D, Delle Fave, G, Falchetti, A, Ferone, D, Goretzki, P, Gross, D, Hochhauser, D, Keleştimur, F, Kianmanesh, R, Knapp, W, Knigge, Up, Komminoth, P, Körner, M, Kos Kudła, B, Kvols, L, Kwekkeboom, Dj, Lewington, V, Lopes, Jm, Manfredi, R, Mcnicol, Am, Mitry, E, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, Pauwels, S, Pape, Uf, Pavel, M, Perren, A, Plöckinger, U, Ramage, J, Ricke, J, Rindi, G, Ruszniewski, P, Sauvanet, A, Scarpa, A, Scoazec, Jy, Sevilla Garcia, Mi, Steinmüller, T, Sundin, A, Taal, B, Van Cutsem, E, Wiedenmann, B, Wildi, S, Yao, Jc, and Zgliczynski, S.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Humans, Neuroendocrine Tumors, Pancreatic Neoplasms, Biology, University hospital, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine
Abstract

a Department of Gastroenterology, Beaujon Hospital, Clichy , France; b Department of Oncology, Institut Catala d’Oncologia, Barcelona , Spain; c Department of Surgery, Verona University, Verona , Italy; d Department of Endocrinology and Metabolism, Genimatas Hospital, Athens , Greece; e Department of Gastroenterology, Beaujon Hospital, Clichy , France; f Department of Endocrinology, Erasmus MC University, Rotterdam , The Netherlands; g Department of Internal Medicine, Martin University, Martin , Slovakia; h Department of Propaedeutic Internal Medicine, Laiko Hospital, Athens , Greece; i Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; j Department of Gastroenterology, Beaujon Hospital, Clichy , France; k Department of Gastroenterology, Royal Free Hospital, London , UK; l Department of Cell Biology, National Institute of Health, Bethesda, Md. , USA; m Department of Endocrinology, University Hospital, Uppsala , Sweden

Published
2006

6. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors:Echocardiography

Author

Plöckinger, U., Gustafsson, B., Ivan, D., Szpak, W., Davar, J., Åkerstrom, G., Annibale, B., Arnold, R., Bajetta, E., Barkmanova, J., Chen, Y. J., Costa, F., Couvelard, A., Herder, W. D., Fave, G. D., Eriksson, B., Falconi, M., Ferone, D., Gross, D., Grossman, A., Hyrdel, R., Kaltsas, G., Kianmanesh, R., Klöppel, G., Knigge, U. P., Komminoth, P., Kos Kudla, B., Kwekkeboom, D., Lebtahi, R., Lewington, V., Mcnicol, A. M., Mitry, E., Nilsson, O., Öberg, K., O'Connor, J., O'Toole, D., Pape, U. F., Papotti, M., Pavel, M., Perren, A., Platania, M., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scheidhauer, K., Scoazec, J. Y., Sundin, A., Taal, B., Vitek, P., Vullierme, M. P., and Wiedenmann, B.

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Carcinoid tumors, MEDLINE, Carcinoid Heart Disease, carcinoid syndrome, Diagnostic accuracy, Disease, Neuroendocrine tumors, Cellular and Molecular Neuroscience, Endocrinology, cancer diagnosis, Internal medicine, Humans, echocardiography, Medicine, human, medical society, conference paper, medical documentation, Endocrine and Autonomic Systems, business.industry, practice guideline, Medical practice, diagnostic accuracy, medical practice, neuroendocrine tumor, patient information, priority journal, medicine.disease, Medical documents, Neuroendocrine Tumors, business, Carcinoid syndrome
Abstract

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : echocardiography.

Published
2009
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7. Consensus guidelines for the management of patients with liver metastases from digestive (neuro) endocrine tumors: Foregut, midgut, hindgut, and unknown primary

Author

Steinmüller, T., Kianmanesh, R., Falconi, Massimo, Scarpa, Aldo, Taal, B., Kwekkeboom, D., Lopes, J., Perren, A., Nikou, G., Yao, J., Fave, G. D., O'Toole, D., Ahlman, H., Arnold, R., Auernhammer, C., Caplin, M., Christ, E., Couvelard, A., Herder, W. D., Eriksson, B., Ferone, D., Goretzki, P., Gross, D., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Klöppel, G., Knapp, W., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Krenning, E., Kulke, M., Kvols, L., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Öberg, K., O'Connor, J., Pape, U., Pavel, M., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scoazec, J., Garcia, M. S., Sundin, A., Vullierme, M., Wiedenmann, B., Wildi, S., Thomas, Steinmüller, Reza, Kianmanesh, Falconi, Massimo, Aldo, Scarpa, Babs, Taal, Dik J., Kwekkeboom, José M., Lope, Aurel, Perren, George, Nikou, James, Yao, Gian Franco, Delle, Dermot, O'Toole, Frascati Consensus, Conference, Radiology & Nuclear Medicine, and Cardiology

Subjects
medicine.medical_specialty, Consensus, ACTING SOMATOSTATIN ANALOG, Endocrinology, Diabetes and Metabolism, Guidelines as Topic, Biology, HEPATIC ARTERIAL CHEMOEMBOLIZATION, Metastasis, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Endocrine Gland Neoplasms, medicine, Digestive System, Humans, Liver Neoplasms, Endocrine system, Endocrine gland neoplasm, Endocrine and Autonomic Systems, General surgery, Cancer, Hindgut, Midgut, Foregut, LASER-INDUCED THERMOTHERAPY, medicine.disease, HEPATIC ARTERIAL CHEMOEMBOLIZATION, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS, LASER-INDUCED THERMOTHERAPY, ACTING SOMATOSTATIN ANALOG, PORTAL-VEIN EMBOLIZATION, ISLET-CELL CARCINOMA, ISLET-CELL CARCINOMA, PORTAL-VEIN EMBOLIZATION, Unknown primary, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS
Abstract

a DRK Kliniken Westend, Berlin , Germany; b UFR Bichat-Beaujon-Louis Mourier, Service de Chirurgie Digestive, Hopital Louis Mourier, Colombes , France; c Medicine and Surgery, General Surgery Section, MED/18 – General Surgery and d Department of Pathology, University of Verona, Verona , Italy; e Netherlands Cancer Centre, Amsterdam , and f Department of Nuclear Medicine, Erasmus University Medical Center, Rotterdam , The Netherlands

Published
2008

8. Consensus guidelines for the management of patients with digestive neuroendocrine tumors - Well-differentiated jejunal-ileal tumor/carcinoma

Author

Eriksson, B., Klöppel, G., Krenning, E., Ahlman, H., Plöckinger, U., Wiedenmann, B., Arnold, R., Auernhammer, C., Körner, M., Rindi, G., Wildi, S., Caplin, M., Fave, G. D., Ferone, D., Goretzki, P., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Komminoth, P., Kos Kudła, B., Kvols, L., Kwekkeboom, D., Lopes, J., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pavel, M., Perren, A., Ramage, J., Ricke, J., Ruszniewski, P., Scarpa, Aldo, Scoazec, J., Garcia, M. S., Steinmüller, T., Taal, B., Vullierme, M., Yao, J., and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Consensus, MIDGUT CARCINOID-TUMORS, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, RECEPTOR-MEDIATED RADIOTHERAPY, RADIOLABELED SOMATOSTATIN ANALOG, RECOMBINANT INTERFERON-ALPHA, RADIONUCLIDE THERAPY, MIDGUT CARCINOID-TUMORS, Endocrinology, Diabetes and Metabolism, RADIONUCLIDE THERAPY, Neuroendocrine tumors, digestive system, RECOMBINANT INTERFERON-ALPHA, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Carcinoma, Humans, Medicine, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, Gastrointestinal Neuroendocrine Tumor, RADIOLABELED SOMATOSTATIN ANALOG, Jejunal Neoplasms, Endocrine and Autonomic Systems, business.industry, digestive, oral, and skin physiology, Metastatic carcinoid tumor, Cancer, medicine.disease, Carcinoma, Neuroendocrine, Well differentiated, Ileal Neoplasms, Practice Guidelines as Topic, Radionuclide therapy, Neuroendocrine therapy, business, RECEPTOR-MEDIATED RADIOTHERAPY
Abstract

Consensus guidelines for the management of patients with digestive neuroendocrine tumors : well-differentiated jejunal-ileal tumor/carcinoma

Published
2008
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9. Poorly differentiated carcinomas of the foregut (gastric, duodenal and pancreatic)

Author

Nilsson, O., Cutsem, E. V., Fave, G. D., Yao, J., Pavel, M., Mcnicol, A., Garcia, M. S., Knapp, W., Keleştimur, F., Sauvanet, A., Pauwels, S., Kwekkeboom, D., Caplin, M., Ahlman, H., Arnold, R., Bechstein, W., Cadiot, G., Christ, E., Chung, D., Couvelard, A., Herder, W. D., Eriksson, B., Falchetti, A., Falconi, Massimo, Ferone, D., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Jensen, R., Kaltsas, G., Kianmanesh, R., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Lopes, J., Manfredi, Riccardo, Mitry, E., Niederle, B., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pape, U., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scoazec, J., Steinmüller, T., Sundin, A., Taal, B., Vullierme, M., Wiedenmann, B., Wildi, S., Zgliczynski, S., Radiology & Nuclear Medicine, O., Nilsson, E. V., Cutsem, G. D., Fave, J., Yao, M., Pavel, A., Mcnicol, M. S., Garcia, W., Knapp, F., Keleştimur, A., Sauvanet, S., Pauwel, D., Kwekkeboom, M., Caplin, and Falconi, M

Subjects
SMALL-CELL-CARCINOMA, NEUROENDOCRINE CARCINOMAS, TUMORS, CHEMOTHERAPY, STOMACH, MANAGEMENT, CISPLATIN, ETOPOSIDE, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Biology, Cellular and Molecular Neuroscience, CISPLATIN, Endocrinology, Duodenal Neoplasms, Stomach Neoplasms, Internal medicine, STOMACH, SMALL-CELL-CARCINOMA, medicine, MANAGEMENT, Humans, ddc:610, Royal infirmary, Endocrine and Autonomic Systems, Poorly differentiated, General surgery, GASTRIC/DUODENAL, Carcinoma, CHEMOTHERAPY, TUMORS, Neuroendocrine Carcinomas, Pancreatic Neoplasms, ETOPOSIDE, NEUROENDOCRINE CARCINOMAS
Abstract

a Department of Pathology, Gothenburg University, Gothenburg , Sweden; b Department of Gastroenterology, Gasthuisberg University, Leuven , Belgium; c Department of Gastroenterology, Ospedale S. Andrea, Rome , Italy; d Department of Oncology, University of Texas, Houston, Tex. , USA; e Department of Endocrinology, Erlangen University, Erlangen , Germany; f Department of Oncology and Pathology, Royal Infirmary Hospital, Glasgow , UK; g Department of Oncology, Virgen de la Victoria Hospital, Malaga , Spain; h Department of Nuclear Medicine, Medizinische Hochschule Hannover, Hannover , Germany; i Department of Endocrinology, Erciyes University, Kayseri , Turkey; j Department of Surgery, Beaujon Hospital, Clichy , France; k Department of Nuclear Medicine, Catholique de Louvain University, Brussels , Belgium; l Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; m Department of Gastroenterology, Royal Free Hospital, London , UK

Published
2006

11. Competitive Testing of the WHO 2010 versus the WHO 2017 Grading of Pancreatic Neuroendocrine Neoplasms: Data from a Large International Cohort Study.

Author

Rindi G, Klersy C, Albarello L, Baudin E, Bianchi A, Buchler MW, Caplin M, Couvelard A, Cros J, de Herder WW, Delle Fave G, Doglioni C, Federspiel B, Fischer L, Fusai G, Gavazzi F, Hansen CP, Inzani F, Jann H, Komminoth P, Knigge UP, Landoni L, La Rosa S, Lawlor RT, Luong TV, Marinoni I, Panzuto F, Pape UF, Partelli S, Perren A, Rinzivillo M, Rubini C, Ruszniewski P, Scarpa A, Schmitt A, Schinzari G, Scoazec JY, Sessa F, Solcia E, Spaggiari P, Toumpanakis C, Vanoli A, Wiedenmann B, Zamboni G, Zandee WT, Zerbi A, and Falconi M

Subjects
Adult, Aged, Cohort Studies, Female, History, 21st Century, Humans, Internationality, Male, Middle Aged, Neoplasm Grading methods, Neoplasm Grading standards, Neoplasm Grading trends, Neuroendocrine Tumors epidemiology, Pancreatic Neoplasms epidemiology, Retrospective Studies, Societies, Medical organization & administration, Societies, Medical standards, World Health Organization, Medical Oncology organization & administration, Medical Oncology standards, Medical Oncology trends, Neuroendocrine Tumors pathology, Pancreatic Neoplasms pathology, Practice Guidelines as Topic standards
Abstract

Background: The World Health Organization (WHO) and the American Joint Cancer Committee (AJCC) modified the grading of pancreatic neuroendocrine neoplasms from a three-tier (WHO-AJCC 2010) to a four-tier system by introducing the novel category of NET G3 (WHO-AJCC 2017)., Objectives: This study aims at validating the WHO-AJCC 2017 and identifying the most effective grading system., Method: A total of 2,102 patients were enrolled; entry criteria were: (i) patient underwent surgery; (ii) at least 2 years of follow-up; (iii) observation time up to 2015. Data from 34 variables were collected; grading was assessed and compared for efficacy by statistical means including Kaplan-Meier method, Cox regression analysis, Harrell's C statistics, and Royston's explained variation in univariable and multivariable analyses., Results: In descriptive analysis, the two grading systems demonstrated statistically significant differences for the major category sex but not for age groups. In Cox regression analysis, both grading systems showed statistically significant differences between grades for OS and EFS; however, no statistically significant difference was observed between the two G3 classes of WHO-AJCC 2017. In multivariable analysis for the two models fitted to compare efficacy, the two grading systems performed equally well with substantially similar optimal discrimination and well-explained variation for both OS and EFS. The WHO-AJCC 2017 grading system retained statistically significant difference between the two G3 classes for OS but not for EFS., Conclusions: The WHO-AJCC 2017 grading system is at least equally performing as the WHO-AJCC 2010 but allows the successful identification of the most aggressive PanNET subgroup. Grading is confirmed as probably the most powerful tool for predicting patient survival., (© 2018 S. Karger AG, Basel.)

Published
2018
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12. Prognostic and predictive roles of MGMT protein expression and promoter methylation in sporadic pancreatic neuroendocrine neoplasms.

Author

Schmitt AM, Pavel M, Rudolph T, Dawson H, Blank A, Komminoth P, Vassella E, and Perren A

Subjects
Adult, Aged, Antineoplastic Agents, Alkylating therapeutic use, Biomarkers, Pharmacological metabolism, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Dacarbazine analogs & derivatives, Dacarbazine therapeutic use, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuroendocrine Tumors genetics, Neuroendocrine Tumors metabolism, Neuroendocrine Tumors therapy, Pancreatic Neoplasms genetics, Pancreatic Neoplasms metabolism, Pancreatic Neoplasms therapy, Prognosis, Temozolomide, Ubiquitin-Protein Ligases metabolism, DNA Methylation, DNA Modification Methylases genetics, DNA Modification Methylases metabolism, DNA Repair Enzymes genetics, DNA Repair Enzymes metabolism, Neuroendocrine Tumors diagnosis, Pancreatic Neoplasms diagnosis, Promoter Regions, Genetic, Tumor Suppressor Proteins genetics, Tumor Suppressor Proteins metabolism
Abstract

Background/aims: O(6)-methylguanine-methyltransferase (MGMT) is an important enzyme of DNA repair. MGMT promoter methylation is detectable in a subset of pancreatic neuroendocrine neoplasms (pNEN). A subset of pNEN responds to the alkylating agent temozolomide (TMZ). We wanted to correlate MGMT promoter methylation with MGMT protein loss in pNEN, correlate the findings with clinico-pathological data and determine the role of MGMT to predict response to TMZ chemotherapy., Methods: We analysed a well-characterized collective of 141 resected pNEN with median follow-up of 83 months for MGMT protein expression and promoter methylation using methylation-specific PCR (MSP). A second collective of 10 metastasized, pretreated and progressive patients receiving TMZ was used to examine the predictive role of MGMT by determining protein expression and promoter methylation using primer extension-based quantitative PCR., Results: In both collectives there was no correlation between MGMT protein expression and promoter methylation. Loss of MGMT protein was associated with an adverse outcome, this prognostic value, however, was not independent from grade and stage in multivariate analysis. Promoter hypermethylation was significantly associated with response to TMZ., Conclusion: Loss of MGMT protein expression is associated with adverse outcome in a surgical series of pNET. MGMT promoter methylation could be a predictive marker for TMZ chemotherapy in pNEN, but further, favourably prospective studies will be needed to confirm this result and before this observation can influence clinical routine., (© 2014 S. Karger AG, Basel.)

Published
2014
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13. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes.

Author

Jensen RT, Cadiot G, Brandi ML, de Herder WW, Kaltsas G, Komminoth P, Scoazec JY, Salazar R, Sauvanet A, and Kianmanesh R

Subjects
Humans, Neuroendocrine Tumors diagnosis, Neuroendocrine Tumors epidemiology, Neuroendocrine Tumors therapy, Pancreatic Neoplasms diagnosis, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms therapy
Published
2012
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14. ENETS consensus guidelines for the management of bone and lung metastases from neuroendocrine tumors.

Author

Kos-Kudła B, O'Toole D, Falconi M, Gross D, Klöppel G, Sundin A, Ramage J, Oberg K, Wiedenmann B, Komminoth P, Van Custem E, Mallath M, Papotti M, and Caplin M

Subjects
Bone Neoplasms therapy, Humans, Lung Neoplasms therapy, Bone Neoplasms secondary, Digestive System Neoplasms pathology, Lung Neoplasms secondary, Neuroendocrine Tumors pathology
Published
2010
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15. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification.

Author

Klöppel G, Couvelard A, Perren A, Komminoth P, McNicol AM, Nilsson O, Scarpa A, Scoazec JY, Wiedenmann B, Papotti M, Rindi G, and Plöckinger U

Subjects
Adenocarcinoma diagnosis, Adenocarcinoma pathology, Adenocarcinoma therapy, Biomarkers analysis, Humans, Lymphatic Metastasis diagnosis, Lymphatic Metastasis pathology, Neoplasm Staging methods, Neuroendocrine Tumors pathology, Neuroendocrine Tumors therapy, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy, Prognosis, Stomach Neoplasms pathology, Stomach Neoplasms therapy, Neuroendocrine Tumors diagnosis, Pancreatic Neoplasms diagnosis, Stomach Neoplasms diagnosis
Published
2009
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16. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs.

Author

Kwekkeboom DJ, Krenning EP, Lebtahi R, Komminoth P, Kos-Kudła B, de Herder WW, and Plöckinger U

Subjects
Humans, Neuroendocrine Tumors metabolism, Radiotherapy methods, Neuroendocrine Tumors drug therapy, Neuroendocrine Tumors radiotherapy, Radioisotopes therapeutic use, Receptors, Peptide metabolism, Somatostatin analogs & derivatives
Abstract

The purpose of this guideline is to assist physicians caring for patients with neuroendocrine tumors in considering eligibility criteria for peptide receptor radionuclide therapy (PRRT), and in defining the minimum requirements for PRRT. This guideline also makes recommendations on what minimal patient, tumor, and treatment outcome characteristics should be reported for PRRT in order to make comparisons between studies possible. It is not this guideline's aim to give specific recommendations on the use of specific radiolabeled somatostatin analogs for PRRT because different analogs are being used, and their availability depends on national law and local permissions., (Copyright 2009 S. Karger AG, Basel.)

Published
2009
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18. Well-differentiated gastric tumors/carcinomas.

Author

Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B, Kianmanesh R, Hochhauser D, Arnold R, Ahlman H, Pauwels S, Kwekkeboom DJ, and Rindi G

Subjects
Carcinoma classification, Carcinoma epidemiology, Humans, Stomach Neoplasms classification, Stomach Neoplasms epidemiology, Carcinoma diagnosis, Carcinoma therapy, Stomach Neoplasms diagnosis, Stomach Neoplasms therapy
Published
2006
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