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1. Subject Index Vol. 57, 1993

Author

Flemming W. Bach, Fuad Fares, Rodrigo Kuljis, Benito Regueiro, Kunïkazu Kondo, Moshe Gavish, Paul M. Dubois, Iván Nagy, Harry Brandt, Andreas Kjaer, Alessandro D. Genazzani, Zsuzsanna Ács, Kjell Fuxe, Guido Ficarra, Samuel M. McCann, Emanuel Meller, Michael D. DeBellis, B Bidzinska, Shalom Bar-Ami, Andrea Gallinelli, Valeria Sibilia, Kazuo Otake, Philip W. Gold, Jørgen Warberg, Konstantine T. Kalogeras, Stefano Angioni, Donna L. Tempel, Ulrich Knigge, Antonio Pecile, F. V. Vega, Rodrigo O. Kuljis, Antonio Cintra, Ulrich Renner, Gian Paolo Trentini, Christoph J. Auernhammer, Dipak K. Sarkar, Jamshid Rabii, Juan-Pablo Advis, Koki Fukuhara, Bruce S. McEwen, Luís Lima, Mark A. Demitrack, Nicholas C. Vamvakopoulos, Clara V. Alvarez, Francesca Guidobono, Esperanza Cancio, Karen Bohmaker, Felice Petraglia, Charles D. Conover, M. Criscuolo, Michaela Diamant, V. Solfrini, Takashi Murase, Rabia Bouali-Benazzouz, Maryse Bonnin, Bernd Bunnemann, Jason Diamond, A. G. Reznikov, Jan-Ake Gustafsson, Kent E. Vrana, Zsuzsanna Mergl, Jesús Devesa, Aziz El Amraoui, Víctor M. Arce, Abraham Weizman, Harvey J. Whitfield, Vladimir K. Patchev, Sarah F. Leibowitz, Marie-Claude Audy, Mitchel A. Kling, Günter K. Stalla, Johanna Stalla, Sam Okret, Shanaz M. Tejani-Butt, Jesús A.F. Tresguerres, Lawrence A. Frohman, Zamir Amiri, Stephen J. Walker, Francesca Bortolotti, Charles Conover, Samuel J. Listwak, Yutaka Oiso, Carmela Netti, David de Wied, Jianxin Yang, Balakrishna M. Prasad, Béla Halász, Tracy Puza, George P. Chrousos, Michael Schütte, David Okrongly, Amir Kaviani, Gábor B. Makara, Fernando Domínguez, Juan Zalvide, Menek Goldstein, Gyula Horvath, Joh Y. Lew, Andrea R. Genazzani, O. A. Müller, Makoto Sato, and Carlos Dieguez

Subjects
Cellular and Molecular Neuroscience, medicine.medical_specialty, Endocrinology, Index (economics), Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Subject (documents), Medical physics, Psychology
Published
1993
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2. Contents, Vol. 57, 1993

Author

Kjell Fuxe, Moshe Gavish, Harry Brandt, Andreas Kjaer, Samuel M. McCann, Jørgen Warberg, Philip W. Gold, Konstantine T. Kalogeras, Antonio Pecile, Mark A. Demitrack, F. V. Vega, Stephen J. Walker, Francesca Bortolotti, Harvey J. Whitfield, Ulrich Knigge, Michael Schütte, Antonio Cintra, Emanuel Meller, Menek Goldstein, Rodrigo Kuljis, Abraham Weizman, Andrea Gallinelli, Clara V. Alvarez, Flemming W. Bach, Charles D. Conover, Nicholas C. Vamvakopoulos, Francesca Guidobono, Andrea R. Genazzani, Takashi Murase, Maryse Bonnin, Gábor B. Makara, Jason Diamond, Sarah F. Leibowitz, Rabia Bouali-Benazzouz, Samuel J. Listwak, Joh Y. Lew, Günter K. Stalla, Marie-Claude Audy, Kunïkazu Kondo, Esperanza Cancio, David de Wied, Jianxin Yang, Jan-Ake Gustafsson, Karen Bohmaker, Kent E. Vrana, Juan-Pablo Advis, Makoto Sato, Mitchel A. Kling, Otto-Albrecht Müller, Ulrich Renner, Koki Fukuhara, Johanna Stalla, Fuad Fares, Aziz El Amraoui, George P. Chrousos, Carlos Dieguez, Stefano Angioni, Shanaz M. Tejani-Butt, Balakrishna M. Prasad, Gyula Horváth, Sam Okret, Iván Nagy, Michael D. DeBellis, B Bidzinska, Alexander G. Reznikov, Valeria Sibilia, Benito Regueiro, Vladimir K. Patchev, Dipak K. Sarkar, Felice Petraglia, Bruce S. McEwen, Luís Lima, M. Criscuolo, V. Solfrini, Jesús A.F. Tresguerres, Rodrigo O. Kuljis, Gian Paolo Trentini, David Okrongly, Amir Kaviani, Víctor M. Arce, Shalom Bar-Ami, Lawrence A. Frohman, Charles Conover, Béla Halász, Bernd Bunnemann, Alessandro D. Genazzani, Kazuo Otake, Paul M. Dubois, Zsuzsanna Ács, Guido Ficarra, Zsuzsanna Mergl, Christoph J. Auernhammer, Jamshid Rabii, Yutaka Oiso, Carmela Netti, Zamir Amiri, Tracy Puza, Fernando Domínguez, Juan Zalvide, Donna L. Tempel, Michaela Diamant, and Jesús Devesa

Subjects
Cellular and Molecular Neuroscience, medicine.medical_specialty, Endocrinology, Traditional medicine, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, business
Published
1993
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3. Effects of the glucocorticoid antagonist RU 486 on pituitary-adrenal function in patients with anorexia nervosa and healthy volunteers: enhancement of plasma ACTH and cortisol secretion in underweight patients

Author

Harry Brandt, Philip W. Gold, Konstantine T. Kalogeras, Mitchel A. Kling, Michael D. DeBellis, Harvey J. Whitfield, Samuel J. Listwak, George P. Chrousos, and Mark A. Demitrack

Subjects
Cortisol secretion, Adult, medicine.medical_specialty, Hypothalamo-Hypophyseal System, Anorexia Nervosa, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Pituitary-Adrenal System, Excretion, Cellular and Molecular Neuroscience, Endocrinology, Adrenocorticotropic Hormone, Double-Blind Method, Internal medicine, medicine, Humans, Glucocorticoids, Psychiatric Status Rating Scales, Endocrine and Autonomic Systems, Body Weight, Mifepristone, Anorexia nervosa (differential diagnoses), Female, Underweight, medicine.symptom, Psychology, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, medicine.drug, Hormone
Abstract

To further explore whether the hypercortisolism of anorexia nervosa reflects an alteration in the set point for corticotropin-releasing hormone (CRH) secretion or is a manifestation of glucocorticoid resistance, we examined plasma ACTH and cortisol responses to the competitive glucocorticoid antagonist RU 486 (10 mg/kg, p.o. at 8.00 h) versus placebo (PBO) in 7 healthy female volunteers and 8 patients with DSM-III-R anorexia nervosa, all of whom were studied while underweight [64.3 +/- 2.1% average body weight (ABW), mean +/- SE] and 5 of whom were restudied longitudinally following refeeding (or = 85% ABW, mean 87.4 +/- 0.4% ABW). Blood samples were obtained from 16.00 to 16.30 h and from 4.00 to 8.00 h following dosing. Underweight anorexics were significantly hypercortisolemic by 24 h urinary free cortisol excretion compared with controls (239 +/- 37 vs. 119 +/- 12 nmol/day, p0.01). Both controls and underweight anorexics had robust early morning (4.00-8.00 h) plasma cortisol responses to RU 486 (465 +/- 61 and 719 +/- 49 nmol/l) compared with PBO (370 +/- 52 and 451 +/- 31 nmol/l; p0.02 and p0.01, respectively). The underweight anorexics showed a significant mean early morning plasma ACTH response to RU compared with placebo (3.28 +/- 0.63 vs. 2.01 +/- 0.24 pmol/l, p0.05), while the controls showed a trend toward an increase in mean plasma ACTH after RU (3.11 +/- 0.36 pmol/l) compared with PBO (2.31 +/- 0.41 pmol/l, p0.13); plasma ACTH means were greater on the RU day than the placebo day at 20 of 25 sampling points (p0.001). However, the increment in ACTH on the RU day compared to the placebo day was greater in the underweight anorexics at the first 20 of 25 consecutive time points of the early morning sampling period (p0.001). Moreover, underweight anorexics showed a significant plasma ACTH and cortisol response to RU 486 at 16.00-16.30 h (8-8.5 h following administration), while the controls showed no significant response of plasma ACTH or cortisol at this time. When restudied following weight recovery, anorexic patients showed reductions in 24-hour urinary free cortisol excretion (to 191 +/- 40 nmol/day) which were no longer significantly elevated compared with control values.(ABSTRACT TRUNCATED AT 400 WORDS)

Published
1993

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