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Start Over Author "Sandra Röske" Journal neuroepidemiology
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1. Contents Vol. 37, 2011

Author

Pornpet Panjapiyakul, Monika Balzer-Geldsetzer, Hans-Ulrich Wittchen, Neşe Güler, Ülkü Türk Börü, Marcelo Schultz, Satz Mengensatzproduktion, Bernadette Boden-Albala, L. Fernando Gonzalez, Ana Sofia Costa, Julián Benito-León, Carlos Romero, Claudia Trenkwalder, Alexander Storch, Mustafa Taşdemir, Ahmed Jusabani, Susanne Gräber-Sultan, Maurice Giroud, Cédric Annweiler, Günther Deuschl, John F. Kurtzke, Rashmi Kumar, Mark Swai, Juha E. Jääskeläinen, Haydar Sur, William K. Gray, Stavropoula Tjoumakaris, Mikael von und zu Fraunberg, Martin Kronenbürger, J. Hernesniemi, Stéphane Haïk, Jaakko Rinne, Antti Ronkainen, Adam E. Handel, Roongroj Bhidayasiri, Terhi Huttunen, Arlette Welaratne, Sabine Nunnemann, Kiyan Heshmat-Ghahdarijani, William K. Wohlgemuth, Christine Schneider, Elif Dilaver Ayık, Christián Begué, Myunghee Cho Paik, Annamaija Riihinen, Sreeram V. Ramagopalan, Thanin Asawavichienjinda, Antti E. Lindgren, Julio R. Vieira, Albertine Aouaba, Alireza Minagar, Thomas Klockgether, Carlos D'Giano, Maren Bodden, Hervé Aube, Thomas Gasser, Kanittha Chimabutra, Jörg B. Schulz, Wolfgang H. Oertel, Eric Benzenine, Renu Srismith, Estefania Rojas, Véronique Vaillant, Isabelle Capek, Vahab Moradi, Yves Cottin, Luca Mascitelli, M.S.V. Elkind, Alexander Kurz, Hans Förstl, Arda Duman, Richard Dodel, Safieh Nonahal, Alberto R. Ramos, Chuanhui Dong, Sandra Röske, Timo Koivisto, Tatjana Rundek, Samart Tananyakul, Kammant Phanthumchinda, Nele Schmidt, Mitja I. Kurki, Chanvit Tharathep, Ana Lia Taratuto, Hannah Gardener, Oliver Riedel, Catherine Quantin, Guiqing Yao, Tibor Schuster, Jean-Philippe Brandel, Catherine Sackley, Marianne Zeller, Olivier Beauchet, Gustavo Sevlever, Chiadi U. Onyike, Anwar Rizvi, Ayşegül Kumaş, Luc Lorgis, Brit Mollenhauer, Daniela Berg, Horacio Martinetto, Yannick Béjot, Pascal Jabbour, Annick Alpérovitch, Elke Kalbe, Serhan Yıldırım, Siegfried Muhlack, Supaporn Choeytim, Melanie Calvert, Anupama Bhave, Janine Diehl-Schmid, Yolsilp Suchonwanich, Abbas Ghorbani, Carola Seifried, Talat Rizvi, Annika Spottke, Inga Liepelt-Scarfone, Ralph L. Sacco, Paramjit Gill, Hardev Pall, Mitchell S.V. Elkind, Karsten Witt, Thomas Müller, Benjamin Eaton, Masoud Etemadifar, Amir-Hadi Maghzi, Natnipa Wannachai, Aaron S. Dumont, Taavi Saavalainen, Richard Walker, Roli Bhargava, Ullrich Wüllner, Mark R. Goldstein, Sudaratana Limpabandhu, Rüdiger Hilker, Clinton B. Wright, Yeseon P. Moon, Thomas J Hoppitt, Dominique Salomon, Manuel J. Somoza, Druck Reinhardt Druck Basel, and Dirk Woitalla

Subjects
Traditional medicine, Epidemiology, business.industry, Medicine, Neurology (clinical), business
Published
2011
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2. Parkinson’s Disease and Dementia: A Longitudinal Study (DEMPARK)

Author

Richard Dodel, Christine Schneider, Annika Spottke, Thomas Gasser, Brit Mollenhauer, Daniela Berg, Hans-Ulrich Wittchen, Carola Seifried, Oliver Riedel, Susanne Gräber-Sultan, Sandra Röske, Günther Deuschl, Alexander Storch, Ullrich Wüllner, Ana Sofia Costa, Jörg B. Schulz, Nele Schmidt, Elke Kalbe, Claudia Trenkwalder, Inga Liepelt-Scarfone, Maren Bodden, Wolfgang H. Oertel, Monika Balzer-Geldsetzer, Karsten Witt, Martin Kronenbürger, Thomas Klockgether, and Rüdiger Hilker

Subjects
complications [Lewy Body Disease], Male, Motor disorder, Pediatrics, Longitudinal study, Parkinson's disease, Epidemiology, Disease, Neuropsychological Tests, Cohort Studies, 0302 clinical medicine, genetics [Lewy Body Disease], genetics [Parkinson Disease], blood [Parkinson Disease], Prospective Studies, 030212 general & internal medicine, 10. No inequality, Prospective cohort study, complications [Dementia], ddc:616, Aged, 80 and over, medicine.diagnostic_test, Parkinson Disease, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Parkinson, Demenz, Kohortenstudie, Disease Progression, Female, complications [Parkinson Disease], complications [Cognitive Dysfunction], Parkinson’s disease, Dementia, MCI, cognitive impairment, Cohort study, Lewy Body Disease, Mild Cognitive Impairment, medicine.medical_specialty, 03 medical and health sciences, genetics [Dementia], medicine, Humans, Parkinson's disease, dementia, MCI, cognitive impairment, cohort study, Cognitive Dysfunction, ddc:610, Aged, blood [Lewy Body Disease], business.industry, genetics [Cognitive Dysfunction], Magnetic resonance imaging, medicine.disease, blood [Dementia], blood [Cognitive Dysfunction], Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Background: Parkinson’s disease (PD) is a progressive neurodegenerative motor disorder. However, non-motor complications frequently alter the course of the disease. A particularly disabling non-motor symptom is dementia. Methods/Design: The study is designed as a multicentre prospective, observational cohort study of about 700 PD patients aged 45–80 years with or without dementia and PD-mild cognitive impairment (MCI). The patients will be recruited in eight specialized movement disorder clinics and will be followed for 36 months. Information about the patients’ functional status will be assessed at baseline and 6-/12- month intervals. In addition, 120 patients with dementia with Lewy bodies (DLB) will be included. Well-established standardized questionnaires/tests will be applied for detailed neuropsychological assessment. In addition, patients will be asked to participate in modules including volumetric MRI, genetic parameters, and neuropsychology to detect risk factors, early diagnostic biomarkers and predictors for dementia in PD. Results: The study included 604 PD patients by March 2011; 56.3% were classified as having PD alone, with 30.6% of patients suffering from PD-MCI and 13.1% from PD with dementia. The mean age of the cohort was 68.6 ± 7.9 years, with a mean disease duration of 6.8 ± 5.4 years. There was a preponderance of patients in the earlier Hoehn and Yahr stages. Conclusion: The main aim of the study is to characterize the natural progression of cognitive impairment in PD and to identify factors which contribute to the evolution and/or progression of the cognitive impairment. To accomplish this aim we established a large cohort of PD patients without cognitive dysfunction, PD patients with MCI, and PD patients with dementia, to characterize these patients in a standardized manner, using imaging (serial structural MRI), genetic and proteomic methods in order to improve our understanding of the course of the PD process and the development of cognitive dysfunction and dementia in this disease. The inclusion of the DLB patients will start in the second quarter of 2011 in the BMBF-funded follow-up project LANDSCAPE.

Published
2011
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