1. Abnormal accumulation of intestinal fluid following ingestion of an unabsorbable carbohydrate in patients with irritable bowel syndrome: an MRI study
- Author
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Nils-Einar Kløw, K. S. Moi, Ragnhild Undseth, K. Arnljot, Arnold Berstad, and Jørgen Valeur
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Distension ,Gastroenterology ,Irritable Bowel Syndrome ,Young Adult ,Lactulose ,Internal medicine ,Dietary Carbohydrates ,medicine ,Edema ,Humans ,Ingestion ,Ascending colon ,Irritable bowel syndrome ,Aged ,chemistry.chemical_classification ,Endocrine and Autonomic Systems ,business.industry ,digestive, oral, and skin physiology ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Small intestine ,Intestines ,Postprandial ,medicine.anatomical_structure ,chemistry ,Female ,business ,FODMAP ,medicine.drug - Abstract
Background Postprandial discomfort following intake of poorly absorbable, but fermentable carbohydrates is a common complaint in patients with irritable bowel syndrome (IBS). We used lactulose as a model substance for this group of symptom triggering carbohydrates, aiming to visualize the intestinal response in IBS patients compared to healthy controls. Methods Patients with IBS according to Rome III criteria (n = 52) and healthy controls (n = 16) underwent a lactulose challenge test. By using magnetic resonance imaging, we measured small bowel water content (SBWC), and distension (diameter) of the distal ileum and the colon, both in fasting state and 1 h after ingestion of 10 g lactulose. We recorded symptoms after lactulose ingestion. Key Results Lactulose provoked significantly more symptoms in IBS patients than in healthy controls (p
- Published
- 2014
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