1. Network, clinical and sociodemographic features of cognitive phenotypes in temporal lobe epilepsy
- Author
-
Bruce Hermann, Lisa L. Conant, Cole J. Cook, Gyujoon Hwang, Camille Garcia-Ramos, Kevin Dabbs, Veena A. Nair, Jedidiah Mathis, Charlene N. Rivera Bonet, Linda Allen, Dace N. Almane, Karina Arkush, Rasmus Birn, Edgar A. DeYoe, Elizabeth Felton, Rama Maganti, Andrew Nencka, Manoj Raghavan, Umang Shah, Veronica N. Sosa, Aaron F. Struck, Candida Ustine, Anny Reyes, Erik Kaestner, Carrie McDonald, Vivek Prabhakaran, Jeffrey R. Binder, and Mary E. Meyerand
- Subjects
Temporal lobe epilepsy (TLE) ,Phenotype ,Cognitive impairment ,Comorbidity ,Socioeconomic status ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
This study explored the taxonomy of cognitive impairment within temporal lobe epilepsy and characterized the sociodemographic, clinical and neurobiological correlates of identified cognitive phenotypes. 111 temporal lobe epilepsy patients and 83 controls (mean ages 33 and 39, 57% and 61% female, respectively) from the Epilepsy Connectome Project underwent neuropsychological assessment, clinical interview, and high resolution 3T structural and resting-state functional MRI. A comprehensive neuropsychological test battery was reduced to core cognitive domains (language, memory, executive, visuospatial, motor speed) which were then subjected to cluster analysis. The resulting cognitive subgroups were compared in regard to sociodemographic and clinical epilepsy characteristics as well as variations in brain structure and functional connectivity. Three cognitive subgroups were identified (intact, language/memory/executive function impairment, generalized impairment) which differed significantly, in a systematic fashion, across multiple features. The generalized impairment group was characterized by an earlier age at medication initiation (P
- Published
- 2020
- Full Text
- View/download PDF